Results 31 to 40 of about 6,842,401 (297)

NFIA determines the cis-effect of genetic variation on Ucp1 expression in murinethermogenic adipocytes

iScience, 2022
Summary: Thermogenic brown and beige adipocytes counteract obesity by enhancing energy dissipation via uncoupling protein-1 (Ucp1). However, the effect of genetic variation on these cells, a major source of disease susceptibility, has been less well ...
Yuta Hiraike, Shuichi Tsutsumi, Takahito Wada, Misato Oguchi, Kaede Saito, Masahiro Nakamura, Satoshi Ota, Michinori Koebis, Harumi Nakao, Atsu Aiba, Gaku Nagano, Haruya Ohno, Kenji Oki, Masayasu Yoneda, Takashi Kadowaki, Hiroyuki Aburatani, Hironori Waki, Toshimasa Yamauchi   +17 more
doaj   +1 more source

Molecular Physiology of Kainate Receptors [PDF]

Physiological Reviews, 2001
A decade ago, our understanding of the molecular properties of kainate receptors and their involvement in synaptic physiology was essentially null. A plethora of recent studies has altered this situation profoundly such that kainate receptors are now regarded as key players in the modulation of transmitter release, as important mediators of the ...
Lerma Gómez, Juan, Paternain, Ana V., Rodríguez-Moreno, Antonio, López-García, Juan C.   +3 more
openaire   +3 more sources

Oxytocin promotes hepatic regeneration in elderly mice

iScience, 2021
Summary: Liver aging impairs the ability of hepatocyte regeneration. Recent studies have found that oxytocin (OT) plays an important role in promoting tissue repair and maintaining differentiation and regeneration of stem cells. Here, we reported that OT
Dan Luo, Bin Jin, Xiangyu Zhai, Jing Li, Chuanyong Liu, Wei Guo, Jingxin Li   +6 more
doaj   +1 more source

Propionate induces intestinal oxidative stress via Sod2 propionylation in zebrafish

iScience, 2021
Summary: Propionate and propionyl-CoA accumulation have been associated with the development of mitochondrial dysfunction. In this study, we show that propionate induces intestinal damage in zebrafish when fed a high-fat diet (HFD). The intestinal damage
Qianwen Ding, Zhen Zhang, Yu Li, Hongliang Liu, Qiang Hao, Yalin Yang, Einar Ringø, Rolf Erik Olsen, Jihong Liu Clarke, Chao Ran, Zhigang Zhou   +10 more
doaj   +1 more source

Adult-Onset Myopathy with Constitutive Activation of Akt following the Loss of hnRNP-U

iScience, 2020
Summary: Skeletal muscle has the remarkable ability to modulate its mass in response to changes in nutritional input, functional utilization, systemic disease, and age.
Debalina Bagchi, Benjamin D. Mason, Kodilichi Baldino, Bin Li, Eun-Joo Lee, Yuteng Zhang, Linh Khanh Chu, Sherif El Raheb, Indranil Sinha, Ronald L. Neppl   +9 more
doaj   +1 more source

Myofiber androgen receptor increases muscle strength mediated by a skeletal muscle splicing variant of Mylk4

iScience, 2021
Summary: Androgens have a robust effect on skeletal muscles to increase muscle mass and strength. The molecular mechanism of androgen/androgen receptor (AR) action on muscle strength is still not well known, especially for the regulation of sarcomeric ...
Iori Sakakibara, Yuta Yanagihara, Koichi Himori, Takashi Yamada, Hiroshi Sakai, Yuichiro Sawada, Hirotaka Takahashi, Noritaka Saeki, Hiroyuki Hirakawa, Atsushi Yokoyama, So-ichiro Fukada, Tatsuya Sawasaki, Yuuki Imai   +12 more
doaj   +1 more source

Molecular physiology of copepods - from biomarkers to transcriptomes and back again.

Comparative Biochemistry and Physiology - Part D:Genomics and Proteomics, 2019
Planktonic copepods are a diverse and abundant group of small (~mm sized) aquatic animals that play a critical role in linking the base of the food chain with higher trophic levels.
A. Tarrant, B. Nilsson, B. Hansen
semanticscholar   +1 more source

Hepatic Levels of DHA-Containing Phospholipids Instruct SREBP1-Mediated Synthesis and Systemic Delivery of Polyunsaturated Fatty Acids

iScience, 2020
Summary: Polyunsaturated fatty acids (PUFAs), such as docosahexaenoic acid (DHA) and arachidonic acid (ARA), play fundamental roles in mammalian physiology.
Daisuke Hishikawa, Keisuke Yanagida, Katsuyuki Nagata, Ayumi Kanatani, Yoshiko Iizuka, Fumie Hamano, Megumi Yasuda, Tadashi Okamura, Hideo Shindou, Takao Shimizu   +9 more
doaj   +1 more source

Depletion of cardiac cardiolipin synthase alters systolic and diastolic function

iScience, 2021
Summary: Cardiolipin (CL) is a major cardiac mitochondrial phospholipid maintaining regular mitochondrial morphology and function in cardiomyocytes. Cardiac CL production includes its biosynthesis and a CL remodeling process.
Elia Smeir, Sarah Leberer, Annelie Blumrich, Georg Vogler, Anastasia Vasiliades, Sandra Dresen, Carsten Jaeger, Yoann Gloaguen, Christian Klose, Dieter Beule, P. Christian Schulze, Rolf Bodmer, Anna Foryst-Ludwig, Ulrich Kintscher   +13 more
doaj   +1 more source

Molecular physiology of chemical defenses in a poison frog

Journal of Experimental Biology, 2019
Poison frogs sequester small molecule lipophilic alkaloids from their diet of leaf litter arthropods for use as chemical defenses against predation.
Stephanie N. Caty, Aurora Alvarez-Buylla, G. Byrd, C. Vidoudez, A. Roland, Elicio E. Tapia, B. Budnik, S. Trauger, L. A. Coloma, L. O’Connell   +9 more
semanticscholar   +1 more source