Results 51 to 60 of about 4,156,910 (157)

Mechanobiology and the extracellular matrix in pulmonary fibrosis

iScience
Summary: The extracellular matrix (ECM) is a crucial component of the lung, providing both tissue stability and elasticity. While certain pathologic changes in the ECM, such as fibrotic foci, have long been recognized as hallmarks of pulmonary fibrosis ...
Ingo Ganzleben, Benjamin D. Medoff
doaj   +1 more source

Gene regulatory network inference with popInfer reveals the dynamic regulation of hematopoietic stem cell quiescence

iScience
Summary: Inference of gene regulatory networks (GRNs) can reveal cell state transitions from single-cell genomics data. However, obstacles to temporal inference from snapshot data are difficult to overcome.
Megan K. Rommelfanger, Marthe Behrends, Yulin Chen, Jonathan Martinez, Nikith Kurella, Nino Geisler, Deepthi Guturu, Martin Bens, Lingyun Xiong, Zijin Xiang, K. Lenhard Rudolph, Adam L. MacLean   +11 more
doaj   +1 more source

Clinical Exercise Physiology Accreditation: An Audit of Existing Standards

, 2023
Background: Health professions such as clinical exercise physiology are founded on a set of standards that outline base level knowledge, skills, and competencies to define the roles and scope of practice of the profession.
Nathan E. Reeves, Carly Ryan, Ryan, Carly, Davison, Kade, Kade Davison, Reeves, Nathan E   +5 more
core   +1 more source

Multiparametric imaging of spatio-temporal cAMP signaling, transmembrane potential, and intracellular calcium in the intact heart

iScience
Summary: The spatiotemporal dynamics of intracellular second messengers and signaling molecules, including cyclic adenosine monophosphate (cAMP), have been studied extensively in isolated cardiomyocytes using Förster resonance energy transfer (FRET ...
I-Ju E. Lee, Jessica L. Caldwell, Lilian R. Mott, Jorge L. Gonzalez, Lianguo Wang, Crystal M. Ripplinger   +5 more
doaj   +1 more source

Dorsal raphe nucleus to pre-Bötzinger complex serotonergic neural circuit is involved in seizure-induced respiratory arrest

iScience, 2022
Summary: Sudden unexpected death in epilepsy (SUDEP) is the leading cause of death among patients with epilepsy. However, the underlying mechanism of SUDEP remains elusive.
HaiXiang Ma, Qian Yu, Yue Shen, XiTing Lian, LeYuan Gu, YuLing Wang, Qing Xu, Han Lu, HaiTing Zhao, Chang Zeng, Kazuki Nagayasu, HongHai Zhang   +11 more
doaj   +1 more source

Neuronal XRN1 is required for maintenance of whole-body metabolic homeostasis

iScience, 2021
Summary: Control of mRNA stability and degradation is essential for appropriate gene expression, and its dysregulation causes various disorders, including cancer, neurodegenerative diseases, diabetes, and obesity.
Shohei Takaoka, Akiko Yanagiya, Haytham Mohamed Aly Mohamed, Rei Higa, Takaya Abe, Ken-ichi Inoue, Akinori Takahashi, Patrick Stoney, Tadashi Yamamoto   +8 more
doaj   +1 more source

The quest for fungal strains and their co-culture potential to improve enzymatic degradation of Chinese distillers’ grain and other agricultural wastes [PDF]

, 2019
Distillers’ grain (DG) is one of the lignocellulosic agricultural waste streams having a high potential for biofuel production, however it is causing health and environmental problems in Southwest region of China because of improper treatment before ...
De Vries, Ronald P., Ming, Chunyan, Wang, Meizhu, Kang, Yingqian, Liao, Wanqing, Zou, Chenggang, Zhao, Liang, Dilokpimol, Adiphol, Molecular Plant Physiology, Sub Molecular Plant Physiology, Dilokpimol, Adiphol; id_orcid   +10 more
core   +2 more sources

Functional Validation of Two Fungal Subfamilies in Carbohydrate Esterase Family 1 by Biochemical Characterization of Esterases From Uncharacterized Branches [PDF]

, 2020
The fungal members of Carbohydrate Esterase family 1 (CE1) from the CAZy database include both acetyl xylan esterases (AXEs) and feruloyl esterases (FAEs). AXEs and FAEs are essential auxiliary enzymes to unlock the full potential of feedstock.
de Vries, Ronald P., Kabel, Mirjam A, Langeveld, Sandra, Molecular Plant Physiology, Underlin, Emilie N., Sub Molecular Plant Physiology, Kabel, Mirjam A., de Vries, Ronald P, Underlin, Emilie Nørmølle, Dilokpimol, Adiphol; id_orcid, Li, Xinxin, Griffin, Kelli, Frommhagen, Matthias, Underlin, Emilie N, Dilokpimol, Adiphol   +14 more
core   +2 more sources

RSU-1 regulates the integrity of dense bodies in muscle cells of aging Caenorhabditis elegans

iScience
Summary: Muscle contraction is vital for animal survival, and the sarcomere is the fundamental unit for this process. However, the functions of many conserved sarcomere proteins remain unknown, as their mutants do not exhibit obvious defects.
Ling Jiang, Xinyan Wang, Dandan Zhang, Karen Wing Yee Yuen, Yu Chung Tse   +4 more
doaj   +1 more source

To flower or not to flower, a temperature-sensitive decision. Characterization of flowering responses at high ambient temperature in Arabidopsis thaliana [PDF]

, 2015
To maximize fitness, plants use environmental cues to optimize growth processes. One of the processes under strong environmental regulation is flowering. Multiple environmental factors influence flowering, including temperature.
Rodenburg, N., Rodenburg, Nicole, Molecular Plant Physiology, Sub Molecular Plant Physiology   +3 more
core   +1 more source