Results 61 to 70 of about 4,368,802 (298)

Multiparametric imaging of spatio-temporal cAMP signaling, transmembrane potential, and intracellular calcium in the intact heart

iScience
Summary: The spatiotemporal dynamics of intracellular second messengers and signaling molecules, including cyclic adenosine monophosphate (cAMP), have been studied extensively in isolated cardiomyocytes using Förster resonance energy transfer (FRET ...
I-Ju E. Lee, Jessica L. Caldwell, Lilian R. Mott, Jorge L. Gonzalez, Lianguo Wang, Crystal M. Ripplinger   +5 more
doaj   +1 more source

The molecular physiology of CRAC channels [PDF]

Immunological Reviews, 2009
Summary:  The Ca2+release‐activated Ca2+ (CRAC) channel is a highly Ca2+‐selective store‐operated channel expressed in T cells, mast cells, and various other tissues. CRAC channels regulate critical cellular processes such as gene expression, motility, and the secretion of inflammatory mediators.
openaire   +2 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Dorsal raphe nucleus to pre-Bötzinger complex serotonergic neural circuit is involved in seizure-induced respiratory arrest

iScience, 2022
Summary: Sudden unexpected death in epilepsy (SUDEP) is the leading cause of death among patients with epilepsy. However, the underlying mechanism of SUDEP remains elusive.
HaiXiang Ma, Qian Yu, Yue Shen, XiTing Lian, LeYuan Gu, YuLing Wang, Qing Xu, Han Lu, HaiTing Zhao, Chang Zeng, Kazuki Nagayasu, HongHai Zhang   +11 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Relative roles of the hypothalamus, pituitary and photoperiod on fetal sheep prolactin [PDF]

, 2004
Thesis (Ph.D.)--University of Adelaide, School of Molecular and Biomedical Science, Discipline of Physiology ...
Houghton, Daniel Charles
core  

Revised Supplemental Materials for Chong et al., 2023 manuscript submission to the American Journal of Physiology - Lung Cellular and Molecular Physiology

, 2023
Revised Supplemental Materials for Chong et al., 2023 manuscript submission to the American Journal of Physiology - Lung Cellular and Molecular ...
Deborah Chong (13018818)
core   +1 more source

Neuronal XRN1 is required for maintenance of whole-body metabolic homeostasis

iScience, 2021
Summary: Control of mRNA stability and degradation is essential for appropriate gene expression, and its dysregulation causes various disorders, including cancer, neurodegenerative diseases, diabetes, and obesity.
Shohei Takaoka, Akiko Yanagiya, Haytham Mohamed Aly Mohamed, Rei Higa, Takaya Abe, Ken-ichi Inoue, Akinori Takahashi, Patrick Stoney, Tadashi Yamamoto   +8 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

RSU-1 regulates the integrity of dense bodies in muscle cells of aging Caenorhabditis elegans

iScience
Summary: Muscle contraction is vital for animal survival, and the sarcomere is the fundamental unit for this process. However, the functions of many conserved sarcomere proteins remain unknown, as their mutants do not exhibit obvious defects.
Ling Jiang, Xinyan Wang, Dandan Zhang, Karen Wing Yee Yuen, Yu Chung Tse   +4 more
doaj   +1 more source