Results 61 to 70 of about 1,247,695 (303)

Molecular physiology of vision

Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics, 2003
Visual sensation results initially from light-induced isomerization of 11-cis-retinal in rhodopsin and cone pigments of photoreceptor cells. This transformation triggers cascades of events, i.e., activation of transducin and cGMP photodiesterase, decrease of cGMP, closure of cGMP-gated channels, and generation of active potential.
openaire   +3 more sources

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

RSU-1 regulates the integrity of dense bodies in muscle cells of aging Caenorhabditis elegans

iScience
Summary: Muscle contraction is vital for animal survival, and the sarcomere is the fundamental unit for this process. However, the functions of many conserved sarcomere proteins remain unknown, as their mutants do not exhibit obvious defects.
Ling Jiang, Xinyan Wang, Dandan Zhang, Karen Wing Yee Yuen, Yu Chung Tse   +4 more
doaj   +1 more source

The role of Phe150 in human voltage-gated proton channel

iScience, 2022
Summary: The voltage-gated proton channel Hv1 is a member of voltage-gated ion channels containing voltage-sensing domains (VSDs). The VSDs are made of four membrane-spanning segments (S1 through S4), and their function is to detect changes in membrane ...
Xin Wu, Lu Zhang, Liang Hong
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Ion channels: structural basis for function and disease. [PDF]

, 1996
Ion channels are ubiquitous proteins that mediate nervous and muscular function, rapid transmembrane signaling events, and ionic and fluid balance. The cloning of genes encoding ion channels has led to major strides in understanding the mechanistic basis
Goldstein, SA
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Analysis of phenotypic plasticity in response to water constraints in coffee plants growing under field conditions [PDF]

, 2008
In a context of climate change, adaptation of perennial plantations to water constraints becomes a major concern for wood and fruit productivity. Adaptation depends on the level of genetic diversity in breeding and natural populations, as well as their ...
Andrade, Alan Carvalho, Gion, Jean-Marc, Guerra, Antonio Fernando, Jourdan, Christophe, Leroy, Thierry, Marraccini, Pierre, Pot, David, Rocha, Omar C., Rodrigues, Gustavo Costa   +8 more
core  

Identification and Characterization of the Lipid Transport System in the Tarantula Grammostola rosea [PDF]

, 2015
Lipids due to its hydrophobic nature are transported in the hemolymph mainly by lipoproteic fractions. In the present work we studied the lipoproteic fractions present in the hemolymph of the spider Grammostola rosea.
Cunningham, Monica Liliana, Garcia, Carlos Fernando, Laino, Aldana, Suarez, Gustavo   +3 more
core   +2 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source