Results 81 to 90 of about 4,368,802 (298)

Mechano and chemosensory function of colonic primary afferent fibres in splanchnic and pelvic pathways/ Stuart Matthew Brierley. [PDF]

, 2005
"November 2005"Bibliography: leaves 346-266.366 leaves : ill. (some col.), col. plates ; 30 cm.Thesis (Ph.D.)--University of Adelaide, School of Molecular and Biomedical Sciences, Discipline of Physiology ...
Brierley, Stuart Matthew
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Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Gating of the CIC-1 chloride channel/ Michael Duffield. [PDF]

, 2005
Bibliography: leaves 117-136.vii, 136 leaves : ill. (chiefly col.) ; 30 cm.Thesis (Ph.D.)--University of Adelaide, School of Molecular and Biomedical Science, Discipline of Physiology ...
Duffield, Michael David
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Frontiers in Vascular Physiology _ Speciality Section of Frontiers in Physiology

, 2012
Frontiers in Vascular Physiology is a Specialty Section of Frontiers in Physiology. It is devoted to embracing the field of vascular physiology with all its many facets from the molecular to the intact system level.
ZOCCOLI, GIOVANNA
core   +1 more source

Allicin Regulates Energy Homeostasis through Brown Adipose Tissue

iScience, 2020
Summary: Brown adipose tissue (BAT) is a promising potential therapeutic target for the treatment of obesity and related metabolic diseases. Allicin, a natural product in garlic, has multiple biological and pharmacological functions. However, the role of
Chuanhai Zhang, Xiaoyun He, Yao Sheng, Jia Xu, Cui Yang, Shujuan Zheng, Junyu Liu, Haoyu Li, Jianbing Ge, Minglan Yang, Baiqiang Zhai, Wentao Xu, Yunbo Luo, Kunlun Huang   +13 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Type III adenylyl cyclase is essential for follicular development in female mice and their reproductive lifespan

iScience
Summary: Premature ovarian failure (POF) is a complex and heterogeneous disease that causes infertility and subfertility. However, the molecular mechanism of POF has not been fully elucidated.
Baofang Zheng, Xiaoyu Hu, Yuanhui Hu, Sheng Dong, Xin Xiao, Haoming Qi, Yongdi Wang, Weina Wang, Zhenshan Wang   +8 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Metabolic and endocrine adaptations to intrauterine growth restriction in the juvenile guinea pig / Natasha Kim Campbell. [PDF]

, 2006
Corrections inside front cover."June 2006"Bibliography: 31 leaves.xxix, 264 leaves, xxxi, ii, i : ill. (some col.) ; 30 cm.Thesis (Ph.D.)--University of Adelaide, School of Molecular and Biomedical Science, Discipline of Physiology ...
Campbell, Natasha Kim
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