Results 91 to 100 of about 1,679,089 (219)

DFusMol: predicting molecular properties based on dual-channel attention. [PDF]

Front Mol Biosci
Liu X, Du W, Tang H, Gu Y, Li Z, Fu X.
europepmc   +1 more source

Molecular properties and intramolecular interactions of peptide-conjugated phosphorodiamidate morpholino oligonucleotides. [PDF]

Mol Ther Nucleic Acids
Kliuchnikov E, Maksudov F, Pierson D, Marx KA, Chanda A, Barsegov V.   +5 more
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Molecular Properties of Starch-Water Interactions in the Presence of Bioactive Compounds from Barley and Buckwheat-LF NMR Preliminary Study. [PDF]

Polymers (Basel)
Adamczyk G, Masewicz Ł, Przybył K, Zaryczniak A, Kowalczewski PŁ, Beszterda-Buszczak M, Cichocki W, Baranowska HM.   +7 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

The intrinsically disordered AB region: a key modulator of the molecular properties of human RXRγ. [PDF]

Cell Commun Signal
Sołtys K, Skowronek K, Bystranowska D, Wycisk K, Ożyhar A.   +4 more
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Probing Molecular Properties at Atomic Length Scale Using Charge-State Control. [PDF]

Chem Rev
Patera LL, Fatayer S, Repp J, Gross L.
europepmc   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

A Multi-Task Self-Supervised Strategy for Predicting Molecular Properties and FGFR1 Inhibitors. [PDF]

Adv Sci (Weinh)
Yang X, Wang Y, Lin Y, Zhang M, Liu O, Shuai J, Zhao Q.   +6 more
europepmc   +1 more source