Results 81 to 90 of about 10,169,709 (296)
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
International Journal of Electrochemical Science, 2012 Density functional theory (DFT), using the B3LYP functional, was utilized to study the molecular properties of phenazine (PNZ), phenothiazine (PNTZ), phenoxazine (PNXZ) and 1,12-phenathroline (PNTLD) compounds in order to determine the relationship ...
Mwadham M. Kabanda +2 more
doaj +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Expanding the horizon of molecular electronics via nanoparticle assemblies [PDF]
, 2006 A Clever Combination : Organic Molecules & Nanoparticles In view of current and future technological developments, Si-based mi- croelectronics faces a constant need for miniaturisation.
Bernard, Laetitia
core +1 more source
Spectral Decomposition of Chemical Semantics for Activity Cliffs‐Aware Molecular Property Prediction
Advanced ScienceAccurately predicting physicochemical and biological properties of molecules is vital for modern drug discovery, yet existing deep learning models struggle to replicate the multi‐level reasoning of chemists.
Chaoyang Xie +9 more
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
The Role of Three-Body Interactions on the Equilibrium and Non-Equilibrium Properties of Fluids from Molecular Simulation [PDF]
The aim of this work is to use molecular simulation to investigate the role of three-body interatomic potentials in noble gas systems for two distinct phenomena: phase equilibria and shear flow.
Marcelli, Gianluca
core
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Contacting strategies for molecular electronics [PDF]
, 2014 In the last twenty years, new sophisticated tools to contact single molecules were developed. However, a molecular junction (MJ) constituted by two atomic contacts and bridged by a single or a few molecules does not form a rigid system, in particular at ...
Nef, Cornelia
core +1 more source