Results 231 to 240 of about 6,845,981 (383)

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Molecular Recognition and Modification Strategies of Umami Dipeptides with T1R1/T1R3 Receptors. [PDF]

Molecules
Hu K, Sun G, Yu W, Zhang M, Wang S, Cao Y, Hu D, Liang L, He G, Hu J, Liu W.   +10 more
europepmc   +1 more source

Molecular recognition of trehalose and trehalose analogues by Mycobacterium tuberculosis LpqY-SugABC. [PDF]

Proc Natl Acad Sci U S A, 2023
Liang J, Liu F, Xu P, Shangguan W, Hu T, Wang S, Yang X, Xiong Z, Yang X, Guddat LW, Yu B, Rao Z, Zhang B.   +12 more
europepmc   +1 more source

Molecular recognition between the ribosomal decoding site and natural or non-natural aminoglycosides [PDF]

, 2005
Éric Westhof
openalex   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Molecular Recognition and Chiral Discrimination from NMR and Multi-Scale Simulations. [PDF]

Chemistry
Cabral TLG, Brussolo da Silva JP, Tormena CF, Stein M.   +3 more
europepmc   +1 more source

The pyridazine heterocycle in molecular recognition and drug discovery. [PDF]

Med Chem Res, 2023
Meanwell NA.
europepmc   +1 more source

Molecular recognition between adenine or 2,6-diaminopurine and copper(II) chelates with N,O2,S-tripodal tetradentate chelators having thioether or disulfide donor groups

, 2015
J.M. González-Pérez, Duane Choquesillo‐Lazarte, Alicia Domínguez‐Martín, Hanan El Bakkali, María Eugenia García-Rubiño, Inmaculada Pérez-Toro, Ester Vílchez-Rodríguez, A. Castiñeiras, Valeria Marina Nurchi, J. Niclós‐Gutiérrez   +9 more
openalex   +2 more sources

Molecular basis for AU-rich element recognition and dimerization by the HuR C-terminal RRM [PDF]

, 2019
Nina Ripin, Julien Boudet, Małgorzata Duszczyk, Alexandra Hinniger, Michael Faller, Miroslav Krepl, Abhilash Gadi, Robert J. Schneider, Jiřı́ Šponer, Nicole Meisner‐Kober, Frédéric H.‐T. Allain   +10 more
openalex   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source