Results 51 to 60 of about 130,188 (236)

Incipient Biofouling Detection via Fiber Optical Sensing and Image Analysis in Reverse Osmosis Processes

Membranes, 2023
Reverse osmosis (RO) is a widely used membrane technology for producing process water or tap water that is receiving increased attention due to water scarcity caused by climate change. A significant challenge in any membrane filtration is the presence of
Helge Oesinghaus, Daniel Wanken, Kilian Lupp, Martina Gastl, Martin Elsner, Karl Glas   +5 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

GABAB1e promotes the malignancy of human cancer cells by targeting the tyrosine phosphatase PTPN12

iScience, 2021
Summary: Neurotransmitter receptors are involved in cancer progression. Among them, the heterodimeric GABAB receptor, activated by the main inhibitory neurotransmitter GABA, is composed of the transmembrane GABAB1 and GABAB2 subunits.
Bo Wei, Yini Zhu, Peng Yang, Yong Han, Suyun Wang, Xiaomei Wang, Shuai Xia, Xiaoguang Song, Zhongling Zhang, Sheng Wang, Philippe Rondard, Jean-Philippe Pin, Xinnong Jiang, Jianfeng Liu   +13 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

An odorant receptor for a key odor constituent of ambergris

Communications Biology
Ambergris, a substance derived from the digestive system of sperm whales, has been valued for centuries for its unique aromatic properties. However, historical accounts indicate that certain human populations, particularly in East Asia, utilized ...
Dan Takase, Tomohiro Shirai, Kensuke Misawa, Hiroaki Matsunami, Keiichi Yoshikawa   +4 more
doaj   +1 more source

Chemical Characterization of Red Wine Polymers and Their Interaction Affinity with Odorants

Foods
In order to characterize red wine polymers with regard to their binding properties to aroma compounds (odorants), a qualitative and quantitative analysis of chemical degradation products after different chemical treatments (thiolytic, acidic, and ...
Anna Maria Gabler, Annalena Ludwig, Florian Biener, Magdalena Waldner, Corinna Dawid, Oliver Frank   +5 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Dynamic Changes in Qidan Aroma during Roasting: Characterization of Aroma Compounds and Their Kinetic Fitting

Foods
Qidan is one of the most famous varieties of Wuyi Rock tea and has a strong aroma. The aroma-active compounds in Qidan subject to different roasting times were analyzed using solid-phase microextraction two-dimensional gas chromatography–olfactometry ...
Ying Wang, Yue Duan, Huanlu Song
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Intrinsic motivation for singing in songbirds is enhanced by temporary singing suppression and regulated by dopamine

Scientific Reports, 2021
Behaviors driven by intrinsic motivation are critical for development and optimization of physical and brain functions, but their underlying mechanisms are not well studied due to the complexity and autonomy of the behavior.
Yunbok Kim, Sojeong Kwon, Raghav Rajan, Chihiro Mori, Satoshi Kojima   +4 more
doaj   +1 more source