Results 11 to 20 of about 393,868 (257)

A practical, bioinformatic workflow system for large data sets generated by next-generation sequencing [PDF]

, 2010
Transcriptomics (at the level of single cells, tissues and/or whole organisms) underpins many fields of biomedical science, from understanding the basic cellular function in model organisms, to the elucidation of the biological events that govern the ...
Aaron R. Jex, Altschul, Anja Joachim, Ashburner, Bentley, Bethony, Björnberg, Blaxter, Boag, Bronwyn E. Campbell, Caffrey, Campbell, Cantacessi, Cantacessi, Cantacessi, Cantacessi, Chan, Chang, Cinzia Cantacessi, Clifton, Conesa, Cottee, Cottee, Datu, DeRisi, Doyle, Flicek, Freigofas, Gasser, Golden, Greene, Gupta, Hawdon, Hopkins, Hotez, Hu, Huang, Hunter, Iseli, Jackson, Joachim, Joachim, Keil, Krasky, Letunic, Li, Li, Li, Lipinski, Makedonka Mitreva, Margulies, Matthew J. Nolan, McKay, Metzker, Miller, Miller, Mizuarai, Moreno, Morozova, Moser, Mufson, Mulvenna, Nagaraj, Nagaraj, Neil D. Young, Nikolaou, Nisbet, Olson, Parkinson, Paul W. Sternberg, Pong, Portman, Ranganathan, Ren, Robertson, Robin B. Gasser, Robinson, Ross S. Hall, Sahar Abubucker, Sanger, Sanger, Santos, Shoba Ranganathan, Soderlund, Stathopoulos, Stockdale, Tanaka, Vibranovski, Wang, Williamson, Wilson, Wu, Young, Young, Zhan, Zhong   +95 more
core   +6 more sources

Progress, challenge and prospect of plant plastome annotation

Frontiers in Plant Science, 2023
The plastome (plastid genome) represents an indispensable molecular data source for studying phylogeny and evolution in plants. Although the plastome size is much smaller than that of nuclear genome, and multiple plastome annotation tools have been ...
Xiao-Jian Qu, Dan Zou, Rui-Yu Zhang, Gregory W. Stull, Gregory W. Stull, Ting-Shuang Yi, Ting-Shuang Yi   +6 more
doaj   +1 more source

Impact of annotation error in α-globin genes on molecular diagnosis. [PDF]

PLoS ONE, 2017
Recent studies on the variants in duplicated human alpha globin genes (HBA2 and HBA1) actively target the α-globin gene as molecular modulators for the treatment of β-thalassemia major. Identification of the exact position of variant in HBA1, HBA2 or its
J Francis Borgio
doaj   +1 more source

Biases in the Experimental Annotations of Protein Function and their Effect on Our Understanding of Protein Function Space [PDF]

, 2013
The ongoing functional annotation of proteins relies upon the work of curators to capture experimental findings from scientific literature and apply them to protein sequence and structure data.
Babbitt, Patricia, Babbitt, PC, Friedberg, I, Ream, DC, Schnoes, AM, Thorman, AW   +5 more
core   +8 more sources

MoKCa database - mutations of kinases in cancer [PDF]

, 2009
Members of the protein kinase family are amongst the most commonly mutated genes in human cancer, and both mutated and activated protein kinases have proved to be tractable targets for the development of new anticancer therapies The MoKCa database ...
Alfarano, Altschul, Berman, Braconi Quintaje, Bruford, Burnworth, Chatr-aryamontri, Christopher J. Richardson, Clifford, Costas Mitsopoulous, Daley, Diella, Fernández, Finn, Flicek, Forbes, Frances M. G. Pearl, Gene Ontology Consortium, Greenman, Greenman, Hanahan, Hulo, Kaminker, Kaminker, Kerrien, Koorstra, Lappalainen, Laurence H. Pearl, Letunic, Manning, Marketa Zvelebil, Mishra, Ng, O'Brien, Ortutay, Pagel, Pearl, Qiong Gao, Sawyers, Sjöblom, Stark, Torkamani, UniProt Consortium, Vastrik, Velankar, Wheeler, Wood, Yeats   +47 more
core   +3 more sources

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BMC Bioinformatics, 2005
Background Assignment of function to new molecular sequence data is an essential step in genomics projects. The usual process involves similarity searches of a given sequence against one or more databases, an arduous process for large datasets.
Lang B Franz, Gray Michael W, Koski Liisa B, Burger Gertraud   +3 more
doaj   +1 more source

RNA sequencing analysis of the gametophyte transcriptome from the liverwort, Marchantia polymorpha. [PDF]

PLoS ONE, 2014
The liverwort Marchantia polymorpha is a member of the most basal lineage of land plants (embryophytes) and likely retains many ancestral morphological, physiological and molecular characteristics. Despite its phylogenetic importance and the availability
Niharika Sharma, Chol-Hee Jung, Prem L Bhalla, Mohan B Singh   +3 more
doaj   +1 more source

SIFTER search: a web server for accurate phylogeny-based protein function prediction. [PDF]

, 2015
We are awash in proteins discovered through high-throughput sequencing projects. As only a minuscule fraction of these have been experimentally characterized, computational methods are widely used for automated annotation.
Brenner, Steven E, Luo, Kevin R, Sahraeian, Sayed M   +2 more
core   +5 more sources

Genome reannotation of the lizard Anolis carolinensis based on 14 adult and embryonic deep transcriptomes

BMC Genomics, 2013
Background The green anole lizard, Anolis carolinensis, is a key species for both laboratory and field-based studies of evolutionary genetics, development, neurobiology, physiology, behavior, and ecology. As the first non-avian reptilian genome sequenced,
Eckalbar Walter L, Hutchins Elizabeth D, Markov Glenn J, Allen April N, Corneveaux Jason J, Lindblad-Toh Kerstin, Di Palma Federica, Alföldi Jessica, Huentelman Matthew J, Kusumi Kenro   +9 more
doaj   +1 more source

The complete chloroplast genome sequence of Dryobalanops aromatica

Mitochondrial DNA. Part B. Resources, 2021
Dryobalanops aromatica is a new species in the family of Lauraceae with high content of D-borneol, which is an important raw material of premium spices and medicine widely used in China.
Jihua Wang, Weizhong Huang, Shike Cai, Junliang Zhao   +3 more
doaj   +1 more source