Results 41 to 50 of about 262,782 (224)
Novel tools for conservation genomics: comparing two high-throughput approaches for SNP discovery in the transcriptome of the European hake. [PDF]
PLoS ONE, 2011 The growing accessibility to genomic resources using next-generation sequencing (NGS) technologies has revolutionized the application of molecular genetic tools to ecology and evolutionary studies in non-model organisms. Here we present the case study of
Ilaria Milano +14 more
doaj +1 more source
Frontiers in Genetics, 2023 A wide range of scientific fields, such as forensics, anthropology, medicine, and molecular evolution, benefits from the analysis of mitogenomic data. With the development of new sequencing technologies, the amount of mitochondrial sequence data to be ...
Lisa Fiedler +2 more
doaj +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Improvements in viral gene annotation using large language models and soft alignments
BMC BioinformaticsBackground The annotation of protein sequences in public databases has long posed a challenge in molecular biology. This issue is particularly acute for viral proteins, which demonstrate limited homology to known proteins when using alignment, k-mer, or ...
William L. Harrigan +5 more
doaj +1 more source
GOPET: A tool for automated predictions of Gene Ontology terms
BMC Bioinformatics, 2006 Background Vast progress in sequencing projects has called for annotation on a large scale. A Number of methods have been developed to address this challenging task.
Glatting Karl-Heinz +6 more
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Proteotranscriptomics assisted gene annotation and spatial proteomics of Bombyx mori BmN4 cell line
BMC Genomics, 2020 Background The process of identifying all coding regions in a genome is crucial for any study at the level of molecular biology, ranging from single-gene cloning to genome-wide measurements using RNA-seq or mass spectrometry.
Michal Levin +2 more
doaj +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Draft genome sequence of Venturia carpophila, the causal agent of peach scab
Standards in Genomic Sciences, 2017 Venturia carpophila causes peach scab, a disease that renders peach (Prunus persica) fruit unmarketable. We report a high-quality draft genome sequence (36.9 Mb) of V.
Chunxian Chen +2 more
doaj +1 more source
Accurate protein structure annotation through competitive diffusion of enzymatic functions over a network of local evolutionary similarities. [PDF]
PLoS ONE, 2010 High-throughput Structural Genomics yields many new protein structures without known molecular function. This study aims to uncover these missing annotations by globally comparing select functional residues across the structural proteome.
Eric Venner +5 more
doaj +1 more source