Results 31 to 40 of about 5,099,016 (263)

A hybrid sequence–annotation framework for clinvar variant pathogenicity prediction

Engineering Science and Technology, an International Journal
Variant pathogenicity prediction is an important task in genomic medicine, but reliable classification remains challenging because of class imbalance, heterogeneous variant mechanisms, and potential information leakage when variants from the same gene ...
Ahmed Hamid Ahmed, Nesrin Aydin Atasoy
doaj   +1 more source

Molecular BioComputing Suite: A Word Processor Add-In for the Analysis and Manipulation of Nucleic Acid and Protein Sequence Data

BioTechniques, 2001
In all fields of molecular biology, researchers are increasingly challenged by experiments planned and evaluated on the basis of nucleic acid and protein sequence data generally retrieved from public databases.
Patrick Y. Muller, Etienne Studer, André R. Miserez   +2 more
doaj   +1 more source

3D profile-based approach to proteome-wide discovery of novel human chemokines. [PDF]

PLoS ONE, 2012
Chemokines are small secreted proteins with important roles in immune responses. They consist of a conserved three-dimensional (3D) structure, so-called IL8-like chemokine fold, which is supported by disulfide bridges characteristic of this protein ...
Aurelie Tomczak, Jana Sontheimer, David Drechsel, Rainer Hausdorf, Marc Gentzel, Andrej Shevchenko, Stefanie Eichler, Karim Fahmy, Frank Buchholz, M Teresa Pisabarro   +9 more
doaj   +1 more source

Functional genome Annotation in Bacterial infections: A Review [PDF]

Al Ameen Journal of Medical Sciences, 2021
Functional annotation provides the information of gene about its biological identity and various types of molecular function and biological role like sub-cellular location and its expression.
Sharique Ahmad, Shivani Singh, Shriya Arora, Saurabh Srivastava   +3 more
doaj  

Phylobook: a tool for display, clade annotation and extraction of sequences from molecular phylogenies

BioTechniques
As the volume of sequence data from variable pathogens increases, means of analyzing, annotating and extracting specific taxa for study becomes more difficult. To meet these challenges for datasets with hundreds to thousands of taxa, 'Phylobook' was developed.
Jeffrey C Furlong, Peter D Darley, Wenjie Deng, James I Mullins, Roger E Bumgarner   +4 more
openaire   +3 more sources

The subsystems approach to genome annotation and its use in the Project to Annotate 1000 Genomes [PDF]

, 2005
Overbeek R, Begley T, Butler RM, et al. The subsystems approach to genome annotation and its use in the Project to Annotate 1000 Genomes. Nucleic Acids Research.
Hanson, Andrew, Olson, Robert, McHardy, Alice C., Goesmann, Alexander ; https://orcid.org/, Osterman, Andrei, Stevens, Rick, Butler, Ralph M, Ruckert, Christian, Pusch, Gordon D, Butler, Ralph M., Disz, Terry, de Crecy-Lagard, Valerie, Frank, Ed D, Fonstein, Michael, Gerdes, Svetlana, Larsen, Niels, Portnoy, Vasiliy, Frank, Ed D., Goesmann, Alexander, Crécy-Lagard, Valérie de, Choudhuri, Jomuna V., McHardy, Alice C, Thiele, Ines, Olsen, Gary, Overbeek, Ross, Meyer, Folker, Ye, Yuzhen, Begley, Tadhg, Pusch, Gordon D., Choudhuri, Jomuna V, Chuang, Han-Yu, Krause, Lutz, Kubal, Michael, Iwata-Reuyl, Dirk, Rodionov, Dmitry A, Cohoon, Matthew, Edwards, Robert, Diaz, Naryttza N., Rodionov, Dmitry A., Neuweger, Heiko, Linke, Burkhard, Zagnitko, Olga, Vassieva, Olga, Glass, Elizabeth M., Diaz, Naryttza, Rückert, Christian ; https://orcid.org/, Glass, Elizabeth M, Jensen, Roy, Jamshidi, Neema, Steiner, Jason, Vonstein, Veronika   +50 more
core   +1 more source

PROMPT: a protein mapping and comparison tool

BMC Bioinformatics, 2006
Background Comparison of large protein datasets has become a standard task in bioinformatics. Typically researchers wish to know whether one group of proteins is significantly enriched in certain annotation attributes or sequence properties compared to ...
Frishman Dmitrij, Schmidt Thorsten
doaj   +1 more source

Deep proteogenomics; high throughput gene validation by multidimensional liquid chromatography and mass spectrometry of proteins from the fungal wheat pathogen Stagonospora nodorum [PDF]

, 2009
Background Stagonospora nodorum, a fungal ascomycete in the class dothideomycetes, is a damaging pathogen of wheat. It is a model for necrotrophic fungi that cause necrotic symptoms via the interaction of multiple effector proteins with cultivar ...
Hane, J., Casey Tammy, Casey, T., Hane, J.K., Solomon Peter S, Tan, Kar-Chun, James K Hane, Oliver, R.P., Tammy Casey, Kar-Chun Tan, Richard Lipscombe, Lipscombe Richard, Oliver Richard P, Oliver, Richard, Tan, K-C, Richard P Oliver, Hane James K, Tan Kar-Chun, Solomon, P., Lipscombe, R., Scott Bringans, Peter S Solomon, Bringans, S., Solomon, P.S., Bringans Scott   +24 more
core   +1 more source

Non‐homology‐based prediction of gene functions in maize (Zea mays ssp. mays)

The Plant Genome, 2020
Advances in genome sequencing and annotation have eased the difficulty of identifying new gene sequences. Predicting the functions of these newly identified genes remains challenging.
Xiuru Dai, Zheng Xu, Zhikai Liang, Xiaoyu Tu, Silin Zhong, James C. Schnable, Pinghua Li   +6 more
doaj   +1 more source

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source