A Step-by-Step Computational Protocol for Functional Annotation and Structural Modelling of Insect Chemosensory Proteins [PDF]
Bio-ProtocolInsects rely on chemosensory proteins, including gustatory receptors, to detect chemical cues that regulate feeding, mating, and oviposition behaviours.
Rajeswari Kalepu +4 more
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ChanFAD: A Functional Annotation Database for Ion Channels
Frontiers in Bioinformatics, 2022 Ion channels are integral membrane protein complexes critical for regulation of membrane potential, cell volume, and other signaling events. As complex molecular assemblies with many interacting partners, ion channels have multiple structural and ...
Elizabeth V. Castro +21 more
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Embeddings from deep learning transfer GO annotations beyond homology
Scientific Reports, 2021 Knowing protein function is crucial to advance molecular and medical biology, yet experimental function annotations through the Gene Ontology (GO) exist for fewer than 0.5% of all known proteins.
Maria Littmann +4 more
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Recent advancements in critical care: Part I
Indian Journal of Anaesthesia, 2023 Medical colleges are now developing or refurbishing their anaesthesia intensive care units. In most teaching colleges, the residency post includes working in the critical care unit (CCU).
Palepu B Gopal +5 more
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Mitochondrial DNA. Part B. Resources, 2021 Ankistrodesmus falcatus strain UCP001 is a native oleaginous microalgae isolated from the Peruvian Amazon basin. In this study we sequenced, de novo assembled, and functionally annotated the complete mitochondrial genome of the native oleaginous ...
Marianela Cobos +11 more
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AnsNGS: An Annotation System to Sequence Variations of Next Generation Sequencing Data for Disease-Related Phenotypes [PDF]
Healthcare Informatics Research, 2013 ObjectivesNext-generation sequencing (NGS) data in the identification of disease-causing genes provides a promising opportunity in the diagnosis of disease.
Young-Ji Na, Yonglae Cho, Ju Han Kim
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MoBiDiC Prioritization Algorithm, a Free, Accessible, and Efficient Pipeline for Single-Nucleotide Variant Annotation and Prioritization for Next-Generation Sequencing Routine Molecular Diagnosis [PDF]
The Journal of Molecular Diagnostics, 2018 Interpretation of next-generation sequencing constitutes the main limitation of molecular diagnostics. In diagnosing myopathies and muscular dystrophies, another issue is efficiency in predicting the pathogenicity of variants identified in large genes, especially TTN; current in silico prediction tools show limitations in predicting and ranking the ...
Kevin Yauy +13 more
openaire +2 more sources
Progress, challenge and prospect of plant plastome annotation
Frontiers in Plant Science, 2023 The plastome (plastid genome) represents an indispensable molecular data source for studying phylogeny and evolution in plants. Although the plastome size is much smaller than that of nuclear genome, and multiple plastome annotation tools have been ...
Xiao-Jian Qu +6 more
doaj +1 more source
Impact of annotation error in α-globin genes on molecular diagnosis. [PDF]
PLoS ONE, 2017 Recent studies on the variants in duplicated human alpha globin genes (HBA2 and HBA1) actively target the α-globin gene as molecular modulators for the treatment of β-thalassemia major. Identification of the exact position of variant in HBA1, HBA2 or its
J Francis Borgio
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AutoFACT: An Auto
matic F
unctional A
nnotation and C
lassification T
ool
BMC Bioinformatics, 2005 Background Assignment of function to new molecular sequence data is an essential step in genomics projects. The usual process involves similarity searches of a given sequence against one or more databases, an arduous process for large datasets.
Lang B Franz +3 more
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