Results 71 to 80 of about 5,099,016 (263)

Annotation compatibility working group report [PDF]

, 2006
This report explores the question of compatibility between annotation projects including translating annotation formalisms to each other or to common forms. Compatibility issues are crucial for systems that use the results of multiple annotation projects.
Fang, Alex Chengyu, Contributors A. Meyers, Kübler, Sandra, Palmer, Martha, H. Zinsmeister, Hinrichs, Erhard, Schuler, Karin Kipper, G. Penn, A. C. Fang, E. Loper, M. Poesio, T. Jia-lin, Pustejovsky, James, E. Hovy, E. Hinrichs, L. Levin, B. A. Onyshkevych, Hajicova, Eva, Dorr, Bonnie, N. Xue, Hovy, Ed, Farwell, David, Ferro, Lisa, M. Palmer, Levin, Lori, Meyers, Adam, B. Dorr, D. Farwell, Jia-Lin, Tsai, Wiebe, Janyce, J. Pustejovsky, Poesio, Massimo, Loper, Edward, Onyshkevych, Boyan A., Zinsmeister, Heike, Xue, Nianwen, E. Hajicova, L. Ferro, J. Wiebe, Penn, Gerald, A. Meyers, Dolbey, Andrew, S. Kübler, K. K. Schuler, A. Dolbey   +44 more
core   +1 more source

A game-based approach towards human augmented image annotation. [PDF]

, 2011
PhDImage annotation is a difficult task to achieve in an automated way. In this thesis, a human-augmented approach to tackle this problem is discussed and suitable strategies are derived to solve it.
Seneviratne, Attgalage Lasantha Gunathilaka
core   +4 more sources

Draft genome sequence of Venturia carpophila, the causal agent of peach scab

Standards in Genomic Sciences, 2017
Venturia carpophila causes peach scab, a disease that renders peach (Prunus persica) fruit unmarketable. We report a high-quality draft genome sequence (36.9 Mb) of V.
Chunxian Chen, Clive H. Bock, Bruce W. Wood   +2 more
doaj   +1 more source

Accurate protein structure annotation through competitive diffusion of enzymatic functions over a network of local evolutionary similarities. [PDF]

PLoS ONE, 2010
High-throughput Structural Genomics yields many new protein structures without known molecular function. This study aims to uncover these missing annotations by globally comparing select functional residues across the structural proteome.
Eric Venner, Andreas Martin Lisewski, Serkan Erdin, R Matthew Ward, Shivas R Amin, Olivier Lichtarge   +5 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

An expressed sequence tag survey of gene expression in the pond snail Lymnaea stagnalis, an intermediate vector of Fasciola hepatica [PDF]

, 2005
The pond snail Lymnaea stagnalis is an intermediate vector for the liver fluke Fasciola hepatica, a common parasite of ruminants and humans. Yet, despite being a disease of medical and economic importance, as well as a potentially useful comparative tool,
Davison, A., Blaxter, M. L.
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

An end-to-end generalizable deep learning framework to comprehensively analyze transcriptional regulation

Nature Communications
Genome annotation currently requires performing dozens of molecular assays in hundreds of cell and tissue samples, an expensive endeavor which is impractical to replicate across all species and conditions of interest.
Zhaoxi Zhang, Xiaoya Fan, Jiaxin Zhong, Lijuan Jia, Yuanyuan Han, Chenyi Yang, Zengyou He, Xiaoyan Li, Shing-Tung Yau, Rongling Wu, Charles G. Danko, Zhong Wang   +11 more
doaj   +1 more source

Prediction of enzyme function based on 3D templates of evolutionarily important amino acids

BMC Bioinformatics, 2008
Background Structural genomics projects such as the Protein Structure Initiative (PSI) yield many new structures, but often these have no known molecular functions.
Chen Brian Y, Erdin Serkan, Lisewski Andreas, Ward R Matthew, Kristensen David M, Fofanov Viacheslav Y, Kimmel Marek, Kavraki Lydia E, Lichtarge Olivier   +8 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source