Results 121 to 130 of about 4,180,047 (368)

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

FEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona, Carlo M. Bergamini, Carlo Ferrari, Stefano Volinia, Nicoletta Bianchi   +4 more
wiley   +1 more source

Evolutionary descent of prion genes from a ZIP metal ion transport ancestor [PDF]

, 2009
In the more than 20 years since its discovery, both the phylogenetic origin and cellular function of the prion protein (PrP) have remained enigmatic.
David Westaway, Gerold Schmitt-Ulms, Holger Wille, Joel C. Watts, Sepehr Ehsani   +4 more
core   +1 more source

The transcriptional repressor complex FRS7-FRS12 regulates flowering time and growth in Arabidopsis [PDF]

, 2017
Most living organisms developed systems to efficiently time environmental changes. The plant-clock acts in coordination with external signals to generate output responses determining seasonal growth and flowering time.
De Clercq, Rebecca, De Jaeger, Geert, De Milde, Liesbeth, Dhondt, Stijn, Eeckhout, Dominique, Fernandez Calvo, Patricia, Gevaert, Kris, Goossens, Alain, Heyndrickx, Ken, Inzé, Dirk, Iñigo, Sabrina, Pauwels, Laurens, Ritter Traub, Andrés, Ron, Mily, Shi, Hua, Somers, David E, Vanden Bossche, Robin, Vandepoele, Klaas   +17 more
core   +2 more sources

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

FEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura, Lixiang Wang, Nao Hasuzawa, Ayako Nagayama, Sawako Moriyama, Kenji Ashida, Yoshinori Moriyama, Masatoshi Nomura, Ken Yamamoto   +8 more
wiley   +1 more source

Dataset supporting the use of nematodes as bioindicators of polluted sediments

Data in Brief, 2020
We provide the dataset supporting the research article “Nematodes as bioindicators of polluted sediments using metabarcoding and microscopic taxonomy” [1].
Janina Schenk, Sebastian Höss, Marvin Brinke, Nils Kleinbölting, Henrike Brüchner-Hüttemann, Walter Traunspurger   +5 more
doaj   +1 more source

Distribution of dwell times of a ribosome: effects of infidelity, kinetic proofreading and ribosome crowding

, 2011
Ribosome is a molecular machine that polymerizes a protein where the sequence of the amino acid residues, the monomers of the protein, is dictated by the sequence of codons (triplets of nucleotides) on a messenger RNA (mRNA) that serves as the template ...
Ajeet K Sharma, Basu M Mohanty P K, Debashish Chowdhury, Dixon M, Frank J, Garai A Chowdhury D, Hill T L, Lakatos G, Shaw L B, Spirin A S, Tinoco I   +10 more
core   +1 more source

Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1

FEBS Letters, EarlyView.
Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri, Andrea Lapucci, Giuseppe Orsomando, Nadia Raffaelli, Alberto Chiarugi, Daniela Buonvicino   +5 more
wiley   +1 more source

Exact sequence variants should replace operational taxonomic units in marker-gene data analysis

The ISME Journal, 2017
Recent advances have made it possible to analyze high-throughput marker-gene sequencing data without resorting to the customary construction of molecular operational taxonomic units (OTUs): clusters of sequencing reads that differ by less than a fixed ...
B. Callahan, Paul J. McMurdie, S. Holmes
semanticscholar   +1 more source

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

FEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

A combined molecular typing approach does not discriminate Legionella pneumophila serogroup 1 strains of a predominant sequence-based type in Palermo, Italy

Journal of Infection and Public Health, 2009
Summary: The sequence-based type 1,4,3,1,1,1 of Legionella pneumophila sg.1 is predominant in the Palermo city environment since several years. In this study, extended sequence-based typing and pulsed field gel electrophoresis were used in a combined ...
Celestino Bonura, Caterina Mammina, Antonietta Vella, Santina Belfiore, Alfredo Chiarini, Anna Giammanco   +5 more
doaj   +1 more source