Results 11 to 20 of about 2,165,084 (288)

Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4‐2 using proteome arrays

Molecular Systems Biology, 2009
Target recognition by the ubiquitin system is mediated by E3 ubiquitin ligases. Nedd4 family members are E3 ligases comprised of a C2 domain, 2–4 WW domains that bind PY motifs (L/PPxY) and a ubiquitin ligase HECT domain.
Avinash Persaud, Philipp Alberts, Eva M Amsen, Xuejian Xiong, James Wasmuth, Zachary Saadon, Chris Fladd, John Parkinson, Daniela Rotin   +8 more
doaj   +1 more source

Potassium trihydrogen dioxalate dihydrate (KTO) nonlinear optical (NLO) single crystal for optical limiting application

Results in Physics, 2023
In nonlinear optics, optical power limiting (OPL) compounds are known to be an important class of materials because it has the ability to protect the optical sensor components as well as human eyes from the abrupt intense laser power. Here, we have grown
Ramki Chakaravarthy, Jiang Tao, Chang Liu, Yu Liu, Wei Ren, R Ezhil Vizhi   +5 more
doaj   +1 more source

Metabolic reconstruction identifies strain‐specific regulation of virulence in Toxoplasma gondii

Molecular Systems Biology, 2013
Increasingly, metabolic potential is proving to be a critical determinant governing a pathogen's virulence as well as its capacity to expand its host range. To understand the potential contribution of metabolism to strain‐specific infectivity differences,
Carl Song, Melissa A Chiasson, Nirvana Nursimulu, Stacy S Hung, James Wasmuth, Michael E Grigg, John Parkinson   +6 more
doaj   +1 more source

Interplay of buried histidine protonation and protein stability in prion misfolding

Scientific Reports, 2017
Misofolding of mammalian prion proteins (PrP) is believed to be the cause of a group of rare and fatal neurodegenerative diseases. Despite intense scrutiny however, the mechanism of the misfolding reaction remains unclear.
Anatoly Malevanets, P. Andrew Chong, D. Flemming Hansen, Paul Rizk, Yulong Sun, Hong Lin, Ranjith Muhandiram, Avi Chakrabartty, Lewis E. Kay, Julie D. Forman-Kay, Shoshana J. Wodak   +10 more
doaj   +1 more source

Adsorption of Methyl Orange on Bentonite: Design, Modeling, and Analysis of Experiments [PDF]

Iranian Journal of Chemistry & Chemical Engineering, 2023
The study examines the possibility of removing Methyl Orange (MO) from aqueous solutions using crude bentonite. SEM-EDX (scanning electron microscopy) and XRD (X-Ray Diffraction) analyses were performed to characterize the material.
Fatiha Bessaha, Gania Bessaha, Samira Ziane, Amine Khelifa   +3 more
doaj   +1 more source

Structure of a Ty1 restriction factor reveals the molecular basis of transposition copy number control

Nature Communications, 2021
In Saccharomyces cerevisiae, unchecked proliferation of Ty1 retrotransposons is controlled by the process of copy number control (CNC), which requires the p22/p18 protein, translated from an internal transcript within the Ty1 GAG gene.
Matthew A. Cottee, Sean L. Beckwith, Suzanne C. Letham, Sarah J. Kim, George R. Young, Jonathan P. Stoye, David J. Garfinkel, Ian A. Taylor   +7 more
doaj   +1 more source

Acid Red 114 Removal Using a Low-Cost Material: Experimental Study and Statistical Physics Modeling [PDF]

Iranian Journal of Chemistry & Chemical Engineering
An eco-friendly and cost-effective biosorbent has been developed for the efficient elimination of acid red 114 dye from aqueous media. Batch studies were carried out to determine the effects of various operating parameters, namely the effect of ...
Fatiha Bessaha, Gania Bessaha, Fatima Boucif, Samira Ziane, Nouria Mahrez, Ali Çoruh, Amine Khelifa   +6 more
doaj   +1 more source

An allosteric conduit facilitates dynamic multisite substrate recognition by the SCFCdc4 ubiquitin ligase

Nature Communications, 2017
The WD40 domain of the SCFCdc4ubiquitin ligase targets substrates via multiple phosphorylated degron motifs. The authors define a second degron-binding WD40 pocket that imparts a negative allosteric effect on binding to the primary pocket, and thereby ...
Veronika Csizmok, Stephen Orlicky, Jing Cheng, Jianhui Song, Alaji Bah, Neda Delgoshaie, Hong Lin, Tanja Mittag, Frank Sicheri, Hue Sun Chan, Mike Tyers, Julie D. Forman-Kay   +11 more
doaj   +1 more source

Glucosamine-induced endoplasmic reticulum stress attenuates apolipoprotein B100 synthesis via PERK signaling

Journal of Lipid Research, 2009
Glucosamine impairs hepatic apolipoprotein B100 (apoB100) production by inducing endoplasmic reticulum (ER) stress and enhancing cotranslational and posttranslational apoB100 degradation (Qiu, W., R. K. Avramoglu, A. C. Rutledge, J. Tsai, and K.
Wei Qiu, Qiaozhu Su, Angela C. Rutledge, Jing Zhang, Khosrow Adeli   +4 more
doaj   +1 more source

Engineering a Pseudo-26-kDa Schistosoma Glutathione Transferase from bovis/haematobium for Structure, Kinetics, and Ligandin Studies

Biomolecules, 2021
Glutathione transferases (GSTs) are the main detoxification enzymes in schistosomes. These parasitic enzymes tend to be upregulated during drug treatment, with Schistosoma haematobium being one of the species that mainly affect humans. There is a lack of
Neo Padi, Blessing Oluebube Akumadu, Olga Faerch, Chinyere Aloke, Vanessa Meyer, Ikechukwu Achilonu   +5 more
doaj   +1 more source