Results 21 to 30 of about 19,367,956 (387)

Characterisation of HOIP RBR E3 ligase conformational dynamics using integrative modelling

Scientific Reports, 2022
Multidomain proteins composed of individual domains connected by flexible linkers pose a challenge for structural studies due to their intrinsic conformational dynamics.
Marius Kausas, Diego Esposito, Katrin Rittinger, Franca Fraternali   +3 more
doaj   +1 more source

The crystal and molecular structure of 2,7-diazanaphthalene [PDF]

, 1977
X-ray diffraction data were collected at 20°C on a computer-controlled Philips diffractometer (PW 1100). The structure was solved by direct methods and refined by the full-matrix least-squares method to an R of 0.065 (weighted R 0.046).
Ham, D.M.W. van den, Huiszoon, C., Hummel, G.J. van   +2 more
core   +4 more sources

Molecular ferroelectric contributions to anomalous hysteresis in hybrid perovskite solar cells [PDF]

, 2014
We report a model describing the molecular orientation disorder in CH3NH3PbI3, solving a classical Hamiltonian parametrised with electronic structure calculations, with the nature of the motions informed by ab-initio molecular dynamics.
Anderson P. W., Lines M. E., Matsumoto M., McConnell J. R., Tange O.   +4 more
core   +3 more sources

GLP-1 receptor agonism ameliorates hepatic VLDL overproduction and de novo lipogenesis in insulin resistance

Molecular Metabolism, 2014
Background/objectives: Fasting dyslipidemia is commonly observed in insulin resistant states and mechanistically linked to hepatic overproduction of very low density lipoprotein (VLDL).
Jennifer Taher, Christopher L. Baker, Carmelle Cuizon, Hassan Masoudpour, Rianna Zhang, Sarah Farr, Mark Naples, Celine Bourdon, Zdenka Pausova, Khosrow Adeli   +9 more
doaj   +1 more source

Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4‐2 using proteome arrays

Molecular Systems Biology, 2009
Target recognition by the ubiquitin system is mediated by E3 ubiquitin ligases. Nedd4 family members are E3 ligases comprised of a C2 domain, 2–4 WW domains that bind PY motifs (L/PPxY) and a ubiquitin ligase HECT domain.
Avinash Persaud, Philipp Alberts, Eva M Amsen, Xuejian Xiong, James Wasmuth, Zachary Saadon, Chris Fladd, John Parkinson, Daniela Rotin   +8 more
doaj   +1 more source

The simulation of molecular clouds formation in the Milky Way [PDF]

, 2012
Using 3D hydrodynamic calculations we simulate formation of molecular clouds in the Galaxy. The simulations take into account molecular hydrogen chemical kinetics, cooling and heating processes.
A. M. Sobolev, A. V. Khoperskov, Amores, Asplund, Baba, Bakes, Balbus, Ballesteros-Paredes, Barnes, Beaumont, Begeman, Bergin, Binney, Blitz, Bobylev, Cazaux, Cen, Chou, Cohen, Cox, Dame, Dame, Dobbs, Dobbs, Dobbs, Dobbs, Dobbs, Dobbs, Draine, E. O. Vasiliev, Elmegreen, Elmegreen, Elmegreen, Englmaier, Falgarone, Feldmann, Field, Fridman, Galli, Glover, Goldsmith, Habing, Heyer, Hollenbach, Hollenbach, Kalberla, Kauffmann, Khoperskov, Khoperskov, Kim, Kirsanova, Kwan, Lada, Lada, Larson, Lepine, Levine, Levinson, Mac Low, Maloney, McClure-Griffiths, McKee, Mishurov, Nelson, Rathborne, Roberts, Roberts, Rodriguez-Fernandez, Román-Duval, Román-Zúñiga, S. A. Khoperskov, Shetty, Shetty, Shu, Sofue, Solomon, Stecker, Sutherland, Tasker, Tielens, Tomisaka, Vallee, van Leer, Wada, Wada, Wada, Wada, Wolfire, Zhang   +88 more
core   +1 more source

Molecular Structure and Energy [PDF]

Nature, 1921
IN some recent communications on the structure of molecules based on the Lewis-Langmuir theory the question of the energy of molecules seems to have been left out of account. The models for halogen molecules proposed by Prof. A. O. Rankine (Proc. Roy.
  +10 more sources

Metabolic reconstruction identifies strain‐specific regulation of virulence in Toxoplasma gondii

Molecular Systems Biology, 2013
Increasingly, metabolic potential is proving to be a critical determinant governing a pathogen's virulence as well as its capacity to expand its host range. To understand the potential contribution of metabolism to strain‐specific infectivity differences,
Carl Song, Melissa A Chiasson, Nirvana Nursimulu, Stacy S Hung, James Wasmuth, Michael E Grigg, John Parkinson   +6 more
doaj   +1 more source

Structure of a Ty1 restriction factor reveals the molecular basis of transposition copy number control

Nature Communications, 2021
In Saccharomyces cerevisiae, unchecked proliferation of Ty1 retrotransposons is controlled by the process of copy number control (CNC), which requires the p22/p18 protein, translated from an internal transcript within the Ty1 GAG gene.
Matthew A. Cottee, Sean L. Beckwith, Suzanne C. Letham, Sarah J. Kim, George R. Young, Jonathan P. Stoye, David J. Garfinkel, Ian A. Taylor   +7 more
doaj   +1 more source

Interplay of buried histidine protonation and protein stability in prion misfolding

Scientific Reports, 2017
Misofolding of mammalian prion proteins (PrP) is believed to be the cause of a group of rare and fatal neurodegenerative diseases. Despite intense scrutiny however, the mechanism of the misfolding reaction remains unclear.
Anatoly Malevanets, P. Andrew Chong, D. Flemming Hansen, Paul Rizk, Yulong Sun, Hong Lin, Ranjith Muhandiram, Avi Chakrabartty, Lewis E. Kay, Julie D. Forman-Kay, Shoshana J. Wodak   +10 more
doaj   +1 more source