Results 51 to 60 of about 19,367,956 (387)

A new cellular model to follow Friedreich's ataxia development in a time-resolved way

Disease Models & Mechanisms, 2015
Friedreich's ataxia (FRDA) is a recessive autosomal ataxia caused by reduced levels of frataxin (FXN), an essential mitochondrial protein that is highly conserved from bacteria to primates.
Tommaso Vannocci, Nathalie Faggianelli, Silvia Zaccagnino, Ilaria della Rosa, Salvatore Adinolfi, Annalisa Pastore   +5 more
doaj   +1 more source

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source

Identification of RING E3 pseudoligases in the TRIM protein family

Nature Communications
TRIpartite Motif (TRIM) family proteins have diverse roles across a broad variety of cellular functions, which are largely presumed to depend on their ubiquitin E3 ligase activity, conferred by a RING domain.
Jane Dudley-Fraser, Diego Esposito, Katherine A. McPhie, Coltrane Morley-Williams, Tania Auchynnikava, Katrin Rittinger   +5 more
doaj   +1 more source

Searching molecular structure databases with tandem mass spectra using CSI:FingerID

Proceedings of the National Academy of Sciences of the United States of America, 2015
Significance Untargeted metabolomics experiments usually rely on tandem MS (MS/MS) to identify the thousands of compounds in a biological sample. Today, the vast majority of metabolites remain unknown.
Kai Dührkop, Huibin Shen, Marvin Meusel, Juho Rousu, Sebastian Böcker   +4 more
semanticscholar   +1 more source

Supersonic turbulence and structure of interstellar molecular clouds [PDF]

, 2002
The interstellar medium (ISM) provides a unique laboratory for highly supersonic, driven hydrodynamics turbulence. We present a theory of such turbulence, confirm it by numerical simulations, and use the results to explain observational properties of ...
B. Dubrulle, B. G. Elmegreen, B. G. Elmegreen, D. Chappell, D. H. Porter, D. Porter, E. A. Novikov, E. C. Ostriker, E. Falgarone, E. Falgarone, H. Politano, J. Cho, M. A. de Avillez, M. J. Korpi, P. Padoan, Paolo Padoan, R. B. Larson, R. B. Larson, R. Benzi, R. Benzi, R. Camussi, R. Grauer, S. Boldyrev, Stanislav Boldyrev, U. Frisch, W.-C. Müller, Z.-S. She, Z.-S. She, Åke Nordlund   +28 more
core   +2 more sources

The immunological interface: dendritic cells as key regulators in metabolic dysfunction‐associated steatotic liver disease

FEBS Letters, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi, WanTing Kong, Camille Blériot, Joel T. Haas   +3 more
wiley   +1 more source

Ion selectivity and rotor coupling of the Vibrio flagellar sodium-driven stator unit

Nature Communications, 2023
Bacteria swim using a flagellar motor that is powered by stator units. Vibrio spp. are highly motile bacteria responsible for various human diseases, the polar flagella of which are exclusively driven by sodium-dependent stator units (PomAB).
Haidai Hu, Philipp F. Popp, Mònica Santiveri, Aritz Roa-Eguiara, Yumeng Yan, Freddie J. O. Martin, Zheyi Liu, Navish Wadhwa, Yong Wang, Marc Erhardt, Nicholas M. I. Taylor   +10 more
doaj   +1 more source

Charge mobility of discotic mesophases: A multiscale quantum/classical study

, 2007
A correlation is established between the molecular structure and charge mobility of discotic mesophases of hexabenzocoronene derivatives by combining electronic structure calculations, Molecular Dynamics, and kinetic Monte Carlo simulations.
A. J. Chatten, Denis Andrienko, James Kirkpatrick, Jenny Nelson, Kurt Kremer, Valentina Marcon   +5 more
core   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Molecular mechanism of influenza A NS1-mediated TRIM25 recognition and inhibition

Nature Communications, 2018
NS1 of influenza A virus inhibits TRIM25 activity, which is an E3 ligase important for induction of the interferon response. Here, Koliopoulos et al. present structures of TRIM25 and NS1 and show how NS1 binding interferes with substrate recognition of ...
Marios G. Koliopoulos, Mathilde Lethier, Annemarthe G. van der Veen, Kevin Haubrich, Janosch Hennig, Eva Kowalinski, Rebecca V. Stevens, Stephen R. Martin, Caetano Reis e Sousa, Stephen Cusack, Katrin Rittinger   +10 more
doaj   +1 more source