Results 51 to 60 of about 19,554,258 (410)

A new cellular model to follow Friedreich's ataxia development in a time-resolved way

Disease Models & Mechanisms, 2015
Friedreich's ataxia (FRDA) is a recessive autosomal ataxia caused by reduced levels of frataxin (FXN), an essential mitochondrial protein that is highly conserved from bacteria to primates.
Tommaso Vannocci, Nathalie Faggianelli, Silvia Zaccagnino, Ilaria della Rosa, Salvatore Adinolfi, Annalisa Pastore   +5 more
doaj   +1 more source

Charge mobility of discotic mesophases: A multiscale quantum/classical study

, 2007
A correlation is established between the molecular structure and charge mobility of discotic mesophases of hexabenzocoronene derivatives by combining electronic structure calculations, Molecular Dynamics, and kinetic Monte Carlo simulations.
A. J. Chatten, Denis Andrienko, James Kirkpatrick, Jenny Nelson, Kurt Kremer, Valentina Marcon   +5 more
core   +1 more source

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source

Identification of RING E3 pseudoligases in the TRIM protein family

Nature Communications
TRIpartite Motif (TRIM) family proteins have diverse roles across a broad variety of cellular functions, which are largely presumed to depend on their ubiquitin E3 ligase activity, conferred by a RING domain.
Jane Dudley-Fraser, Diego Esposito, Katherine A. McPhie, Coltrane Morley-Williams, Tania Auchynnikava, Katrin Rittinger   +5 more
doaj   +1 more source

Clustering in stable and unstable nuclei in $p$-shell and $sd$-shell regions

, 2003
According to microscopic calculations with antisymmetrized molecular dynamics, we studied cluster features in stable and unstable nuclei. A variety of structure was found in stable and unstable nuclei in the $p$-shell and $sd$-shell regions.
Azaiez, Freer, Freer, H. Horiuchi, Kanada-En'yo, Kimura, Korsheninnikov, M. Kimura, Motobayashi, Ohkubo, Shimoura, Utsuno, Y. Kanada-En'yo, Yamagami   +13 more
core   +1 more source

The immunological interface: dendritic cells as key regulators in metabolic dysfunction‐associated steatotic liver disease

FEBS Letters, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi, WanTing Kong, Camille Blériot, Joel T. Haas   +3 more
wiley   +1 more source

Ion selectivity and rotor coupling of the Vibrio flagellar sodium-driven stator unit

Nature Communications, 2023
Bacteria swim using a flagellar motor that is powered by stator units. Vibrio spp. are highly motile bacteria responsible for various human diseases, the polar flagella of which are exclusively driven by sodium-dependent stator units (PomAB).
Haidai Hu, Philipp F. Popp, Mònica Santiveri, Aritz Roa-Eguiara, Yumeng Yan, Freddie J. O. Martin, Zheyi Liu, Navish Wadhwa, Yong Wang, Marc Erhardt, Nicholas M. I. Taylor   +10 more
doaj   +1 more source

Nanobodies Protecting From Lethal SARS-CoV-2 Infection Target Receptor Binding Epitopes Preserved in Virus Variants Other Than Omicron

Frontiers in Immunology, 2022
The emergence of SARS-CoV-2 variants that escape from immune neutralization are challenging vaccines and antibodies developed to stop the COVID-19 pandemic.
José M. Casasnovas, Yago Margolles, María A. Noriega, María Guzmán, Rocío Arranz, Roberto Melero, Mercedes Casanova, Juan Alberto Corbera, Nereida Jiménez-de-Oya, Pablo Gastaminza, Urtzi Garaigorta, Juan Carlos Saiz, Miguel Ángel Martín-Acebes, Luis Ángel Fernández   +13 more
doaj   +1 more source

Pre-training of Molecular GNNs via Conditional Boltzmann Generator [PDF]

arXiv, 2023
Learning representations of molecular structures using deep learning is a fundamental problem in molecular property prediction tasks. Molecules inherently exist in the real world as three-dimensional structures; furthermore, they are not static but in continuous motion in the 3D Euclidean space, forming a potential energy surface.
arxiv  

OpenMX Viewer: A web-based crystalline and molecular graphical user interface program [PDF]

J. Mol. Graph. Model. 89, 192-198 (2019), 2019
The OpenMX Viewer (Open source package for Material eXplorer Viewer) is a web-based graphical user interface (GUI) program for visualization and analysis of crystalline and molecular structures and 3D grid data in the Gaussian cube format such as electron density and molecular orbitals.
arxiv   +1 more source