Results 61 to 70 of about 19,367,956 (387)

Nanobodies Protecting From Lethal SARS-CoV-2 Infection Target Receptor Binding Epitopes Preserved in Virus Variants Other Than Omicron

Frontiers in Immunology, 2022
The emergence of SARS-CoV-2 variants that escape from immune neutralization are challenging vaccines and antibodies developed to stop the COVID-19 pandemic.
José M. Casasnovas, Yago Margolles, María A. Noriega, María Guzmán, Rocío Arranz, Roberto Melero, Mercedes Casanova, Juan Alberto Corbera, Nereida Jiménez-de-Oya, Pablo Gastaminza, Urtzi Garaigorta, Juan Carlos Saiz, Miguel Ángel Martín-Acebes, Luis Ángel Fernández   +13 more
doaj   +1 more source

Structure of excited states of Be-11 studied with Antisymmetrized Molecular Dynamics [PDF]

, 2002
The structures of the ground and excited states of Be-11 were studied with a microscopic method of antisymmetrized molecular dynamics. The theoretical results reproduce the abnormal parity of the ground state and predict various kinds of excited states ...
A. A. Korsheninnikov, A. Doté, A. Doté, H. G. Bohlen, H. Horiuchi, H. Sagawa, H. Sagawa, I. Daito, I. Ragnarsson, K. Arai, M. Freer, M. Freer, M. Milin, M. Seya, N. Aoi, N. Itagaki, N. Itagaki, N. Yamaguchi, R. Tamagaki, S. Okabe, S. Okabe, T. Ando, T. Otsuka, T. Suzuki, W. von Oertzen, W. von Oertzen, Y. Kanada-En’yo, Y. Kanada-En’yo, Y. Kanada-En’yo, Y. Kanada-En’yo, Y. Kanada-En’yo, Y. Kanada-En’yo, Y. Kanada-En’yo, Y. Kanada-En’yo, Y. Ogawa   +34 more
core   +3 more sources

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

High carrier mobility and strong fluorescence emission: Toward highly sensitive single‐crystal organic phototransistors

Aggregate, 2023
Organic single crystals (OSCs) offer a unique combination of both individual and collective properties of the employed molecules, but it remains highly challenging to achieve OSCs with both high mobilities and strong fluorescence emissions for their ...
Jingwei Tao, Zhaoyang Liu, Dan Liu, Huanli Dong, Jiangbo Jing, Jiaxing Song, Leijing Liu, Bin Xu, Wenjing Tian   +8 more
doaj   +1 more source

Molecular Structure of Galactokinase [PDF]

Journal of Biological Chemistry, 2003
Galactokinase plays a key role in normal galactose metabolism by catalyzing the ATP-dependent phosphorylation of alpha-D-galactose to galactose 1-phosphate. In humans, mutations in the galactokinase gene can lead to the diseased state referred to as Type II galactosemia. Here we describe the three-dimensional structure of galactokinase from Lactococcus
Hazel M. Holden, James B. Thoden
openaire   +3 more sources

Hydrogen-bonded frameworks for molecular structure determination

Nature Communications, 2019
Single crystal X-ray diffraction is arguably the most definitive method for molecular structure determination, but the inability to grow suitable single crystals can frustrate conventional X-ray diffraction analysis.
Yuantao Li, Sishuang Tang, A. Yusov, James Rose, André Nyberg Borrfors, C. Hu, M. Ward   +6 more
semanticscholar   +1 more source

First-Principles Based Matrix-Green's Function Approach to Molecular Electronic Devices: General Formalism

, 2001
Transport in molecular electronic devices is different from that in semiconductor mesoscopic devices in two important aspects: (1) the effect of the electronic structure and (2) the effect of the interface to the external contact. A rigorous treatment of
Albright, Andersen, Aulbur, Aviram, Baerends, Bormet, Brivio, Büttiker, Büttiker, Caroli, Chelikowsky, Chen, Collier, Danielewicz, Datta, Datta, Dederichs, Dekker, Di Ventra, Dorogi, Dreizler, Elstner, Emberley, Emberley, Feibelman, Feibelman, Ferrante, Ferry, Feynman, Frisch, Gimzewski, Goldhaber-Gordon, Goringe, Gross, Gunnarson, Hall, Haug, Hedin, Hershfield, Hirose, Hoffmann, Hoffmann, Joachim, Joachim, Joachim, Jones, Kadanoff, Keldysh, Kruger, Lake, Landauer, Lang, Lang, Lang, Lang, Lang, Lang, Langreth, Larade, Lundstrom, Lyo, Magoga, Mark A. Ratner, McWeeny, Meir, Meir, Metzger, Mujica, Mujica, Ness, Nitzan, Parr, Perdew, Petrov, Pople, Porath, Reed, Reed, Saito, Scheffler, Stowasser, Supriyo Datta, Tans, Taylor, Tian, Trioni, Wachutkal, Wan, Williams, Wilson, Xue, Xue, Xue, Yaliraki, Yongqiang Xue, Zeller   +95 more
core   +1 more source

The intracellular domain of TLR2 is capable of high‐affinity Zn binding: possible outcomes for the receptor activation

FEBS Letters, EarlyView.
Toll‐like receptors (TLRs) are important in the innate immune system. This study explores the zinc‐binding ability of the TLR2 TIR domain (TLR2TIR). We found that TLR2TIR binds zinc with nanomolar affinity through its cysteine residues. Two of them, C673 and C713, are vital for receptor activation, indicating that zinc may play a role in initiating ...
Vladislav A. Lushpa, Cong Lin, Irina A. Talyzina, Marina V. Goncharuk, Eduard V. Bocharov, Alexander S. Arseniev, Xiaohui Wang, Sergey A. Goncharuk, Konstantin S. Mineev   +8 more
wiley   +1 more source

Preoperative assessment of cardiovascular risk in patients undergoing noncardiac surgery: the Orion study

Monaldi Archives for Chest Disease, 2020
In patients undergoing noncardiac surgery risk indices can estimate patients’ perioperative risk of major cardiovascular complications. The indexes currently in use were derived from observational studies that are now outdated with respect to the current
Giampaolo Scorcu, Annarita Pilleri, Paolo Contu, Pompilio Faggiano, Roberto Floris, Alessandra Mereu, Luisella Pistis, Roberto Sessego, Luigi Valentino, Claudia Sardu   +9 more
doaj   +1 more source

Aux/IAA Gene Family in Plants: Molecular Structure, Regulation, and Function

International Journal of Molecular Sciences, 2018
Auxin plays a crucial role in the diverse cellular and developmental responses of plants across their lifespan. Plants can quickly sense and respond to changes in auxin levels, and these responses involve several major classes of auxin-responsive genes ...
Jie Luo, Jing-Jing Zhou, Jinzhi Zhang
semanticscholar   +1 more source