Results 71 to 80 of about 208,473 (269)

Computational Capacity and Energy Consumption of Complex Resistive Switch Networks [PDF]

, 2015
Resistive switches are a class of emerging nanoelectronics devices that exhibit a wide variety of switching characteristics closely resembling behaviors of biological synapses.
Alireza Goudarzi, Christof Teuscher, Darko Stefanovic, Jens Burger, null null   +4 more
core   +4 more sources

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Beyond the fuzzy lock-and-key: spontaneous symmetry shifts and glycan/lectin logic gates [PDF]

, 2012
Changes in the molecular topology of glycan/lectin interaction may explain observed reaction punctuation driven by experimental gradients in reactant concentration. Adoption of a 'biological renormalization' perspective from statistical physics
Rodrick Wallace
core   +1 more source

Reversible Red Fluorescent Molecular Switches

Angewandte Chemie International Edition, 2006
I see red, I see red, I see red: Optically switchable compounds were synthesized whose visible fluorescence can be quenched down to 6 % with light at 360–400 nm and then restored with red light from a diode laser. The molecular switch offers potential applications in data storage and far-field microscopy with spatial resolution far below the ...
Bossi, M., Belov, V., Polyakova, S., Hell, S.   +3 more
openaire   +4 more sources

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Photo-induced and thermal reactions in thin films of an azobenzene derivative on Bi(111)

New Journal of Physics, 2014
Azobenzene is a prototypical molecular switch which can be interconverted with UV and visible light between a trans and a cis isomer in solution. While the ability to control their conformation with light is lost for many molecular photoswitches in the ...
Christopher Bronner, Petra Tegeder
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Detection of Side Chain Rearrangements Mediating the Motions of Transmembrane Helices in Molecular Dynamics Simulations of G Protein-Coupled Receptors. [PDF]

, 2017
Structure and dynamics are essential elements of protein function. Protein structure is constantly fluctuating and undergoing conformational changes, which are captured by molecular dynamics (MD) simulations.
Gaieb, Zied, Morikis, Dimitrios
core   +2 more sources

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Magnetic qubits as hardware for quantum computers

, 2000
We propose two potential realisations for quantum bits based on nanometre scale magnetic particles of large spin S and high anisotropy molecular clusters. In case (1) the bit-value basis states |0> and |1> are the ground and first excited spin states Sz =
Barenco A, Bennett C H, Chudnovsky E M, del Barco E, DiVincenzo D P, DiVincenzo D P, DiVincenzo D P, E del Barco, E M Chudnovsky, Friedman J R, Gider S, Grover L K, Grover L K, Hernandez J M, J M Hernandez, J Tejada, Lloyd S, Lo H-K, Prokof'ev N V, Schwarzschild B, Shor P W, Shor P W, Shor P W, Shor P W, Shor P W, Shor P W, Stamp P C, T P Spiller, Thomas L   +28 more
core   +1 more source