Results 101 to 110 of about 122,210 (312)
Transmission and evolution of "Mycobacterium tuberculosis" studied by whole genome sequencing and single nucleotide polymorphism-typing [PDF]
, 2015 Each year close to 9 million cases of tuberculosis (TB) are caused by bacteria of the Mycobacterium tuberculosis complex (MTBC). The genetic and phenotypic diversity of the pathogen has been underestimated for a long time.
Stucki, David
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Surgery of Spline-type and Molecular Frames [PDF]
Journal of Fourier Analysis and Applications, 2010 We prove a result about producing new frames for general spline-type spaces by piecing together portions of known frames. Using spline-type spaces as models for the range of certain integral transforms, we obtain results for time-frequency decompositions and sampling.
openaire +3 more sources
, 2013 We previously described a Multilocus Sequence Typing (MLST) scheme based on eight genes that facilitates population genetic and evolutionary analysis of P. acnes.
Patrick, Shelia +20 more
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Cronobacter, the emergent bacterial pathogen Enterobacter sakazakii comes of age; MLST and whole genome sequence analysis [PDF]
, 2014 Background: Following the association of Cronobacter spp. to several publicized fatal outbreaks in neonatal intensive care units of meningitis and necrotising enterocolitis, the World Health Organization (WHO) in 2004 requested the establishment of a ...
Keith A Jolley +5 more
core +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Molecular Typing of Chlamydia trachomatis: An Overview
Indian Journal of Medical Microbiology, 2017 Urogenital infection due to Chlamydia trachomatis (CT) is one of the most common bacterial sexually transmitted infections (STIs) and is a major public health problem worldwide. Molecular characterisation of CT is important for understanding the pathophysiological mechanisms of chlamydial disease and its transmission dynamics in sexual networks ...
Jyoti, Rawre +2 more
openaire +2 more sources
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Application of Molecular Typing Methods to the Study of Medically Relevant Gram-Positive Cocci [PDF]
, 2012 The development of molecular genotyping methods has been a landmark in the possibility of classifying microorganisms below the species level. The ability to differentiate efficiently related bacterial isolates is essential for the control of infectious ...
Mollerach, Marta Eugenia +5 more
core +1 more source