Results 111 to 120 of about 3,360,583 (305)

Review of Molecular Subtyping of Ovarian Cancer and Its Clinical Application

Zhongliu Fangzhi Yanjiu, 2018
Ovarian cancer, with high heterogeneity, is the second common cancer in the female reproductive system malignancy tumors. The molecular typing of ovarian cancer has provided a new basis for exploring its heterogeneity, prognosis evaluation and ...
TAN Fangchun, LI Li
doaj   +1 more source

Evaluation of customised lineage-specific sets of MIRU-VNTR loci for genotyping Mycobacterium tuberculosis complex isolates in Ghana [PDF]

, 2014
Different combinations of variable number of tandem repeat (VNTR) loci have been proposed for genotyping Mycobacterium tuberculosis complex (MTBC). Existing VNTR schemes show different discriminatory capacity among the six human MTBC lineages.
Michael Selasi Nyaho (542676), Yeboah-Manu, Dorothy, Borrell, Sonia, Adwoa Asante-Poku, Michael Selasi Nyaho, Sebastien Gagneux (149824), Iñaki Comas (57109), Dorothy Yeboah-Manu (120059), Gagneux, Sebastien, Adwoa Asante-Poku (335717), Sebastien Gagneux, Sonia Borrell (149821), Comas, Iñaki, Dorothy Yeboah-Manu, Nyaho, Michael Selasi, Sonia Borrell, Asante-Poku, Adwoa, Iñaki Comas   +17 more
core   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Toxicity of Oils Extracted From the Arils of Blighia sapida (K.D. Koenig) in Wistar Rats

Biochemistry Research International
Blighia sapida oil, a substance with a rich history of use for its nutritional, therapeutic, traditional, and cosmetic benefits, was the focus of our study. We investigated the impact of consuming edible oil from B. sapida arils on Wistar rats. The crude
Aklesso Nabede, Haziz Sina, Mélila Mamatchi, Tiatou Souho, Batcha Ouadja, S. M. Ismaël Hoteyi, Hafiz A. Salami, Adolphe Adjanohoun, Lamine Baba-Moussa, Kou’santa Amouzou   +9 more
doaj   +1 more source

Evaluation of molecular typing and serological methods in solving discrepant results of weak and partial D (Rh) in South Egypt

Asian Journal of Transfusion Science, 2019
INTRODUCTION: Rh discrepancies produced by partial and weak D phenotypes are a problem during routine testing. Some blood units with weak and partial D expression may be missed by serology.
Rania M Bakry, Eman Nasreldin, Ashraf E Hassaballa, Samar M Mansour, Sahar A Aboalia   +4 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Nasopharyngeal carriage and risk factors of major meningitis pathogens among asymptomatic healthcare workers in paediatric units in Benin, with serogroup distribution of Neisseria meningitidis

BMC Infectious Diseases
Background Healthcare workers in paediatric settings are in close contact with vulnerable children and may serve as reservoirs and vectors for the transmission of respiratory pathogens such as Streptococcus pneumoniae, Neisseria meningitidis, and ...
Chakir Ishola Bello, Cyriaque Comlan Degbey, Yves Eric Denon, Sessi Armel R. Hinvi, Lamine Baba-Moussa   +4 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source