Results 51 to 60 of about 21,286 (258)
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Moments of inertia for multiquasiparticle configurations
Physical Review C, 2000 8 pages 6 figures, figure 6 ...
Frauendorf, S. +3 more
openaire +6 more sources
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Inertia Loads Simulation and Coupled Vibration Analysis of Roller Test Rig
机车电传动, 2014 Method of driving axle load moment checking for roller test rig based on inertia matching was proposed. Effect of track wheel's inertia on traction and braking test was analyzed, which showed that inertia of track wheel was 6.7% of vehicle inertia.
WANG Jin-tian +3 more
doaj
Modeling and simulation of a passive variable inertia flywheel for diesel generator
Energy Reports, 2020 The power supply system of diesel generators is isolated. Sudden loading and unloading will lead to fluctuation of the engine speed and exert an impact on the power supply quality.
Yiping Zhang +3 more
doaj +1 more source
Nuclear moments of inertia at high spins [PDF]
Nuclear Physics A, 1984 Abstract Nuclei with highest angular momentum are discussed. The production of high spin states, and the basic ideas associated with high spin physics are reviewed. Recent developments from “continuum” γ-ray studies are presented: the measurement of different average moments of inertia gives new information on the interplay between collective and ...
openaire +3 more sources
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source