Monasone Naphthoquinone Biosynthesis and Resistance in
mBio, 2020 Despite the important biological activities of natural product naphthoquinones, the biosynthetic pathways of and resistance mechanisms against such compounds remain poorly understood in fungi.
Mu Li +7 more
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From Random Perturbation to Precise Targeting: A Comprehensive Review of Methods for Studying Gene Function in Monascus Species [PDF]
Journal of FungiMonascus, a genus of fungi known for its fermentation capability and production of bioactive compounds, such as Monascus azaphilone pigments and Monacolin K, have received considerable attention because of their potential in biotechnological applications.
Yunxia Gong +6 more
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Inhibitory effect of Monascus purpureus pigment extracts against fungi and mechanism of action
Frontiers in Sustainable Food Systems, 2023 The fungus Monascus produces several secondary metabolites of different pigment hues. These pigments have shown various biological activities. In this study, Monascus purpureus pigment extracts were tested (in vitro) against Penicillium expansum MTCC ...
Swapna Majhi +3 more
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Enhancement of Monascus Azaphilone Pigments Production Without Citrinin Contamination by Targeting Overexpression of Histone Acetyltransferase MrEsa1 and Deletion of Polyketide Synthase PksCT [PDF]
Journal of FungiMonascus spp. are renowned for producing valuable Monascus azaphilone pigments (MonAzPs), yet their biosynthesis is intrinsically linked to the co-production of the mycotoxin citrinin, posing a significant safety challenge and limiting industrial ...
Jing Zhang +7 more
doaj +2 more sources
Enhanced Monacolin K Production in Monascus purpureus Via Mutagenesis and Nitrogen Source Optimization. [PDF]
J Basic MicrobiolABSTRACT Monascus fungi are valued for their production of Monacolin K (MK), a bioactive compound with recognized lipid‐lowering and multifunctional properties. To enhance MK yield in solid‐state fermentation, this study combined atmospheric and room‐temperature plasma (ARTP) mutagenesis with L‐arginine supplementation.
Yang C, Yajing Y, Housheng H.
europepmc +2 more sources
Improvement of Monacolin K and Pigment Production in Monascus by 5-Azacytidine [PDF]
Journal of FungiMonascus species are known to produce various secondary metabolites with polyketide structures, including Monacolins, pigments, and citrinin. This study investigates the effects of 5-azacytidine on Monascus M1 and RP2.
Chan Zhang +10 more
doaj +2 more sources
Activation of secondary metabolism in Aspergillus and related filamentous fungi through regulatory engineering [PDF]
RSC Chemical BiologyFilamentous fungi are major contributors to diverse secondary metabolites with broad applications to medicine, agriculture, and biotechnology. Advances in genome sequencing and bioinformatic tools have revealed that fungal genomes encode far more ...
Jennifer Shyong, Clay C. C. Wang
doaj +2 more sources
Molecular phylogeny and ecological diversity of endolichenic fungi inhabiting Acarospora schleicheri (Ach.) A. Massal, isolated from a Chilean Andean zone [PDF]
Scientific ReportsHigh-altitude ecosystems in the Andes present diverse extreme environmental conditions, yet the fungal biodiversity associated with crustose lichens remains largely unexplored.
Guillermo Fernandez-Bunster +2 more
doaj +2 more sources
Honeysuckle as a Bio-Enhancer in Monascus purpureus Fermentation: Synergistic Improvement of Monacolin K Yield and Flavor Complexity [PDF]
FoodsRecently, co-fermentation of functional medicinal plants with fungi has emerged as a promising strategy to enhance the overall quality of fermented foods. Monascus fermentation products have long been confronted with bottlenecks in both functionality and
Arzugul Ablimit +10 more
doaj +2 more sources
Co-culture with Lactobacillus plantarum SC-1 facilitates ergosterol synthesis in Monascus purpureus through MpSet1-affected H3K4ac establishment [PDF]
Frontiers in MicrobiologyIntroductionIn fungi, ergosterol synthesis is regulated by multiple transcription factors such as Upc2, but the regulation of ergosterol synthesis in Monascus remains unclear.MethodsWe performed a co-culture system of Monascus purpureus (M.
Zhongling Wu, Zhenmin Liu
doaj +2 more sources