Results 91 to 100 of about 2,173,093 (267)

Analysis of Strata Deformation Patterns Induced by Vertical Shaft Sinking Machine Based on Soil Deformation Zoning: A Case Study of the Zhuyuan Bailonggang Sewage Connecting Pipe Project in Shanghai, China

Applied Sciences
Field measurements with the Plaxis3D 24.1 software were performed on the 17# shaft of the Shanghai Zhuyuan Bailonggang sewage connecting the pipe project to analyze the ground deformation patterns during VSM (vertical shaft sinking machine) construction ...
Ping Lu, Fang Chen, Dongqing Nie, Jiangang Han   +3 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Slope Deformation Prediction Combining Particle Swarm Optimization-Based Fractional-Order Grey Model and K-Means Clustering

Fractal and Fractional
Slope deformation poses significant risks to infrastructure, ecosystems, and human safety, making early and accurate predictions essential for mitigating slope failures and landslides.
Zhenzhu Meng, Yating Hu, Shunqiang Jiang, Sen Zheng, Jinxin Zhang, Zhenxia Yuan, Shaofeng Yao   +6 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Open-pit mine slopes stability analysis based on analytic hierarchy process-fuzzy comprehensive evaluation model

Zhongguo dizhi zaihai yu fangzhi xuebao
The bench slope within an open-pit coal mine plays an important supporting role for coal resource production and transportation. The stability evaluation of the slope is of great significance in guiding continuous mining operations within the mine.
Zhiguo LI, Tao XU, Yongjie LIU, Lichun ZHAO, Yongchao XU, Tianhong YANG, Xiaobin ZHENG   +6 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Spatial dependency enhanced dam safety evaluation: a digital-twin based monitoring platform integrating multi-sensor correlation analytics

Frontiers in Mechanical Engineering
The analysis of monitoring data plays a critical role in dam safety assessment. The data analysis process typically involves three stages: monitoring point information inspection, single-point analysis and early warning, and multi-point data fusion and ...
Yanpian Mao, Yanpian Mao, Lei Hu, Lei Hu, Zhiyong Qi, Zhiyong Qi, Zhengyang Tang, Zhengyang Tang, Jin Yuan, Jin Yuan, Xuhuang Du, Zhongming Dong, Haowen Fang, Haowen Fang   +13 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

The incomplete recovery of Danish coastal waters following reduced nutrient inputs and oligotrophication

Frontiers in Marine Science
Danish coastal waters were severely affected by eutrophication in the 1980s, prompting the implementation of national nutrient reduction plans. The aim of this study was to explore the recovery of Danish coastal waters and report trends for selected ...
Marie Neel Jørgensen, Marie Neel Jørgensen, Nanna Meilholm, Nanna Meilholm, Jesper H. Andersen, Jesper H. Andersen, Jacob Carstensen, Lasse Riemann, Ciarán J. Murray, Ciarán J. Murray   +9 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source