Results 101 to 110 of about 26,362,079 (261)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Surface Deformation Calculation Method Based on Displacement Monitoring Data

Buildings
Considering the importance of calculating surface deformation based on monitoring data, this paper proposes a method for calculating horizontal deformation based on horizontal displacement monitoring data. This study first analyzes the characteristics of
Lin He, Yibin Yao
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Study on Deformation Control of Road-Deep Foundation Pit Passing under Elevated Subway Bridge

Applied Sciences
This paper focuses on the application of pile foundation underpinning technology in a deep foundation pit of a subway Viaduct Project in Beijing. The study aims to address the engineering characteristics of the project, including a large number of new ...
Hua Peng, Bowen Meng, Sui Tan, Li Zhu, Guan Wang   +4 more
doaj   +1 more source

Data for Oil Sands Monitoring - Terrestrial Mammals - 2022–2023

Data on boreal mammal communities from Alberta, Canada, conducted for the joint Federal-Provincial Oil Sands Monitoring program (Terrestrial Biological Monitoring group) from 2022–2023. These data are from four different Landscape Units (LU1, LU13, LU15,
Fisher, Jason, Arthurs, Emerald, Barnas, Andrew, Braun, Megan, Dyck, Marissa, Smith, Rebecca   +5 more
core   +1 more source

Data for: Information extraction of long-term gamma radiation monitoring and its response to geological events

, 2019
The research data were the environmental gamma radiation dose monitoring of Yuelu mountain by using RS-230 from March 2018 to April ...
Guo, Xi, Guo, X (via Mendeley Data)
core   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Estimation of the stability of tailings dams based on genetic algorithm-supported calibration results and monitoring data

Studia Geotechnica et Mechanica
In consideration of the potential consequences, ensuring the safety of tailings dams is of paramount importance. A probable failure mechanism is the loss of global stability, which, in certain cases, may involve shearing within the subsoil. A significant
Grosel Szczepan
doaj   +1 more source

Predicting the Deformation of a Slope Using a Random Coefficient Panel Data Model

Fractal and Fractional
Engineering constructions in coastal areas not only affect existing landslides, but also induce new landslides. Variation of the water level makes the coastal area a geological hazard-prone.
Zhenxia Yuan, Yadong Bian, Weijian Liu, Fuzhou Qi, Haohao Ma, Sen Zheng, Zhenzhu Meng   +6 more
doaj   +1 more source