Results 111 to 120 of about 9,605,458 (396)

Denial of Inpatient Genetic Testing: A Study on Outpatient Yield and Outcomes

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Genetic conditions suspected in children often require genetic testing for accurate diagnoses, but testing remains costly. Case management teams review genetic test requests to improve access for patients while reducing the financial burden for medical institutions.
Cindy Y. Canales, Kathleen Shields, Meagan Choates, Paul Hillman, Laura Farach, Theresa Wittman, Kathryn Leal   +6 more
wiley   +1 more source

IL‐31 levels correlate with pruritus in patients with cholestatic and metabolic liver diseases and is farnesoid X receptor responsive in NASH

Hepatology, EarlyView., 2022
IL‐31 levels correlate with pruritus in patients with cholestatic and metabolic liver diseases Abstract Background and Aims Pruritus is associated with multiple liver diseases, particularly those with cholestasis, but the mechanism remains incompletely understood.
Jun Xu, Ya Wang, Mina Khoshdeli, Matt Peach, Jen‐Chieh Chuang, Julie Lin, Wen‐Wei Tsai, Sangeetha Mahadevan, Wesley Minto, Lauri Diehl, Ruchi Gupta, Michael Trauner, Keyur Patel, Mazen Noureddin, Kris V. Kowdley, Aliya Gulamhusein, Christopher L. Bowlus, Ryan S. Huss, Robert P. Myers, Chuhan Chung, Andrew N. Billin   +20 more
wiley   +1 more source

Toll-like Interleukin -1 Receptor Regulator (TILRR) Protein, a Major Modulator of Inflammation, is Expressed in Normal Human and Macaque Tissues and PBMCs

Journal of Inflammation Research, 2022
Mohammad Abul Kashem,1– 3 Lin Li,2 Xin-Yong Yuan,2 Francis A Plummer1 ,† Ma Luo1,2 1Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, MB, Canada; 2JC Wilt Infectious Diseases Research Center, National ...
Kashem MA, Li L, Yuan XY, Plummer FA, Luo M   +4 more
doaj  

Racism and Aids: African Origin Theories of HIV-1 [PDF]

, 1994
The AIDS epidemic, first discovered in the United States in 1981, has caused a great deal of speculation with regard to the origins of both the HIV-1 retrovirus and the early pathways for the epidemic itself. The African origins theory is the most widely
Hunt, Charles W.
core   +1 more source

Impact of Rapid Exome Sequencing on Pediatric Patients With Cardiomyopathy and Acute Heart Failure

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Few studies describe the impact of rapid exome sequencing (ES) on pediatric cardiomyopathy in urgent clinical settings. Here, we retrospectively report the impact of rapid singleton ES in pediatric patients presented with acute heart failure and isolated cardiomyopathy or myocarditis, between 2021 and 2023 at a single tertiary care center.
Tameemi Abdalla Moady, Tova Hershkovitz, Clair Habib, Ori Attias, Amir Hadash, Galit Tal, Asaad Khoury, Josef Ben‐Ari, Danny Eytan, Tamar Paperna, Karin Weiss   +10 more
wiley   +1 more source

Efficient AAV8 delivery to the liver via isolated hepatic perfusion and analysis of hepatic lobule transduction patterns

Liver Research
Background and aims: Adeno-associated virus (AAV) is becoming an attractive vector due to its low toxicity and minimal immunogenicity. However, liver-targeted AAV gene therapy still faces challenges, such as low delivery efficiency and safety risks ...
Chao Wang, Mingming Fan, Jianrong Liu, Xiaolu Guo, Zhipeng Tan, Xueying Huang, Zhuoran Li, Xiaomei Liu, Ye Zhang, Jianqi Feng, Rui Fang, Li Wang, Qiong Ke   +12 more
doaj   +1 more source

Simian virus 40 in humans

Infectious Agents and Cancer, 2007
Simian virus 40 (SV40) is a monkey virus that was administered to human populations by contaminated vaccines which were produced in SV40 naturally infected monkey cells.
Tognon Mauro, Pancaldi Cecilia, Sabbioni Silvia, Balatti Veronica, Corallini Alfredo, Martini Fernanda   +5 more
doaj   +1 more source

Establishment of a novel cynomolgus monkey model of hyperuricemia

Animal Models and Experimental Medicine, EarlyView.
We established a novel hyperuricemia model in cynomolgus monkeys (A) via oral administration of potassium oxonate, hydrochlorothiazide, and adenine mixed in fruits and vegetables. This model (B) targets uric acid synthesis and enzymatic degradation, and (C) regulates renal and intestinal excretion, thereby stably elevating serum uric acid and serving ...
Ji‐Wei Wang, Le Zhang, Can Yang, Guan‐Cong Luo, Rui‐Chang Liu, Yan‐Jun Xu, Sheng Cheng, Wen‐Yu Jiang, Richard Ward, Yang Yang, Cheng Xiang, Shu An, Tian‐Rui Xu   +12 more
wiley   +1 more source

Molecular determinants of neuroprotection in blood-brain interfaces of the cynomolgus monkey

Frontiers in Pharmacology
The blood-brain barrier (BBB) formed by the cerebral microvessel endothelium and the blood-CSF barrier (BCSFB) formed by the choroid plexus epithelium impact the cerebral bioavailability of drugs and endogenous molecules that contribute to ...
Nathalie Strazielle, Nathalie Strazielle, Sandrine Blondel, Joachim Confais, Rita El Khoury, Hugues Contamin, Jean-François Ghersi-Egea   +6 more
doaj   +1 more source

Challenges of modeling pristane‐induced lupus in non‐human primates

Animal Models and Experimental Medicine, EarlyView.
Systemic lupus erythematosus (SLE) in cynomolgus monkeys was modeled by two intraperitoneal injections of pristane at a dose of 3.5 mL/kg, administered at weeks 1 and 23. Serum samples from all monkeys that received pristane tested positive for antinuclear antibodies.
Elena Vladimirovna Vinogradova, Maria Alexandrovna Varavko, Yakov Yuryevich Ustyugov, Alexey Alexandrovich Aleksandrov, Dmitry Alexandrovich Khochenkov, Yulia Nikolaevna Linkova   +5 more
wiley   +1 more source