Results 31 to 40 of about 9,277,402 (300)

Nonhuman Primate Models of Respiratory Disease: Past, Present, and Future. [PDF]

, 2017
The respiratory system consists of an integrated network of organs and structures that primarily function for gas exchange. In mammals, oxygen and carbon dioxide are transmitted through a complex respiratory tract, consisting of the nasal passages ...
Miller, Lisa, Pinkerton, Kent, Royer, Christopher, Schelegle, Edward   +3 more
core   +1 more source

Tauopathy promotes spinal cord-dependent production of toxic amyloid-beta in transgenic monkeys

Signal Transduction and Targeted Therapy, 2023
Tauopathy, characterized by the hyperphosphorylation and accumulation of the microtubule-associated protein tau, and the accumulation of Aβ oligomers, constitute the major pathological hallmarks of Alzheimer’s disease.
Zhuchi Tu, Sen Yan, Bofeng Han, Caijuan Li, Weien Liang, Yingqi Lin, Yongyan Ding, Huiyi Wei, Lu Wang, Hao Xu, Jianmeng Ye, Bang Li, Shihua Li, Xiao-Jiang Li   +13 more
doaj   +1 more source

[11C]CHIBA-1001 as a novel PET ligand for alpha7 nicotinic receptors in the brain: a PET study in conscious monkeys. [PDF]

PLoS ONE, 2008
BackgroundThe alpha7 nicotinic acetylcholine receptors (nAChRs) play an important role in the pathophysiology of neuropsychiatric diseases such as schizophrenia and Alzheimer's disease.
Kenji Hashimoto, Shingo Nishiyama, Hiroyuki Ohba, Masaaki Matsuo, Tatsuhiko Kobashi, Makoto Takahagi, Masaomi Iyo, Takeru Kitashoji, Hideo Tsukada   +8 more
doaj   +1 more source

Cloning of a gene-edited macaque monkey by somatic cell nuclear transfer

National Science Review, 2019
Cloning of macaque monkeys by somatic cell nucleus transfer (SCNT) allows the generation of monkeys with uniform genetic backgrounds that are useful for the development of non-human primate models of human diseases.
Zhen Liu, Yijun Cai, Zhaodi Liao, Yuting Xu, Yan Wang, Zhanyang Wang, Xiaoyu Jiang, Yuzhuo Li, Yong Lu, Yanhong Nie, Xiaotong Zhang, Chunyang Li, Xinyan Bian, M. Poo, Hung-Chun Chang, Qiang Sun   +15 more
semanticscholar   +1 more source

Mass spectrometry-based identification and whole-genome characterisation of the first pteropine orthoreovirus isolated from monkey faeces in Thailand

BMC Microbiology, 2018
Background The pteropine orthoreovirus (PRV) was isolated from monkey (Macaca fascicularis) faecal samples collected from human-inhabited areas in Lopburi Province, Thailand. These samples were initially obtained to survey for the presence of hepatitis E
Nathamon Kosoltanapiwat, Onrapak Reamtong, Tamaki Okabayashi, Sumate Ampawong, Amporn Rungruengkitkun, Tipparat Thiangtrongjit, Narin Thippornchai, Pornsawan Leaungwutiwong, Aongart Mahittikorn, Hirotake Mori, Thanada Yoohanngoa, Prechaya Yamwong   +11 more
doaj   +1 more source

A CRISPR monkey model unravels a unique function of PINK1 in primate brains

Molecular Neurodegeneration, 2019
Genetically modified rodent models have been valuable for investigating the pathogenesis of neurodegenerative diseases such as Parkinson’s disease (PD). Based on the fact that mutations in the PINK1 gene cause autosomal recessive juvenile parkinsonism, a
Weili Yang, Shihua Li, Xiao-Jiang Li
semanticscholar   +1 more source

THE DISEASES OF MONKEYS. [PDF]

The Lancet, 1883
n ...
openaire   +2 more sources

Vaccine innovation, translational research and the management of knowledge accumulation [PDF]

, 2012
What does it take to translate research into socially beneficial technologies like vaccines? Current policy that focuses on expanding research or strengthening incentives overlooks how the supply and demand of innovation is mediated by problem-solving ...
Andre, Archibugi, Aston, Baird, Baldwin, Bastien, Benison, Bentrup, Blume, Blume, Blume, Blume, Blume, Blume, Bodian, Bonu, Bryder, Burnet, Buse, Carter, Chase, Chataway, Connor, Constant, de Souza, Dosi, Douglas, Esparza, Feinberg, Fleck, Fujimura, Galambos, Gallagher, Garber, Gerschenkron, Girard, Griffin, Hacking, Hilleman, Hopkins, Hopkins, Hortsmann, IAVI, IOM, Kremer, Lanjouw, Marincola, Markel, Mays, McCoy, Mullan, Nelson, Nelson, Nichter, Nightingale, Nightingale, NIH, Ohid Yaqub, Ohka, Oshinsky, Paul, Paul Nightingale, Plotkin, Poltorak, Pérez-Cuevas, Racaniello, Rasti, Ren, Ridley, Robbins, Rogers, Rose, Rosenberg, Sabin, Schofield, Smith, Smith, Time, Time, Tomes, van Lente, Vernick, Vincenti, Weiss, West, Yaqub, Zinkernagel   +86 more
core   +2 more sources

Sequence Analysis of APOE Gene Across Mammalian Species in Thailand

Science Technology and Engineering Journal (STEJ), 2021
The current study utilized five mammalian species, including rhesus monkey (Macaca mulatta), Thai Bangkaew dog (Canis lupus familiaris), Thai domestic cat (Felis catus), tiger (Panthera tigris) and Thai domestic rabbit (Oryctolagus cuniculus) to survey ...
Dechawut Bunyaluk, Wilasinee Srisanyong, Chalothon Amporn   +2 more
doaj   +1 more source

Functional disruption of the dystrophin gene in rhesus monkey using CRISPR/Cas9.

Human Molecular Genetics, 2015
CRISPR/Cas9 has been used to genetically modify genomes in a variety of species, including non-human primates. Unfortunately, this new technology does cause mosaic mutations, and we do not yet know whether such mutations can functionally disrupt the ...
Yongchang Chen, Yinghui Zheng, Yu Kang, Weili Yang, Yuyu Niu, Xiangyu Guo, Zhuchi Tu, Chenyang Si, Hong Wang, Ruxiao Xing, X. Pu, Shang-Hsun Yang, Shihua Li, W. Ji, Xiao-Jiang Li   +14 more
semanticscholar   +1 more source