A CRISPR monkey model unravels a unique function of PINK1 in primate brains
Molecular Neurodegeneration, 2019 Genetically modified rodent models have been valuable for investigating the pathogenesis of neurodegenerative diseases such as Parkinson’s disease (PD). Based on the fact that mutations in the PINK1 gene cause autosomal recessive juvenile parkinsonism, a
Weili Yang, Shihua Li, Xiao-Jiang Li
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[11C]CHIBA-1001 as a novel PET ligand for alpha7 nicotinic receptors in the brain: a PET study in conscious monkeys. [PDF]
PLoS ONE, 2008 BackgroundThe alpha7 nicotinic acetylcholine receptors (nAChRs) play an important role in the pathophysiology of neuropsychiatric diseases such as schizophrenia and Alzheimer's disease.
Kenji Hashimoto +8 more
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Vaccine innovation, translational research and the management of knowledge accumulation [PDF]
, 2012 What does it take to translate research into socially beneficial technologies like vaccines? Current policy that focuses on expanding research or strengthening incentives overlooks how the supply and demand of innovation is mediated by problem-solving ...
Andre +86 more
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Nature, 1960 Diseases of Laboratory Primates By Prof. Theodore C. Ruch. Pp. xxvi + 600. (Philadelphia and London: W. B. Saunders Company, 1959.) 52s. 6d.
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Population dynamics of rhesus macaques and associated foamy virus in Bangladesh. [PDF]
, 2013 Foamy viruses are complex retroviruses that have been shown to be transmitted from nonhuman primates to humans. In Bangladesh, infection with simian foamy virus (SFV) is ubiquitous among rhesus macaques, which come into contact with humans in diverse ...
Andreina Pacheco, M +19 more
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Diagnosis of autoimmune bullous diseases
Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, 2018 Autoimmune bullous disorders (AIBDs) are a heterogeneous group of rare diseases clinically characterized by erosions and/or blisters on the skin and mucous membranes.
N. Beek, D. Zillikens, E. Schmidt
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Multiplex precise base editing in cynomolgus monkeys
Nature Communications, 2020 Due to the polygenic nature of most diseases, simultaneous correction or introduction of single nucleotide variants is needed. Here, the authors demonstrated the feasibility of multiplex base editing for polygenes disease modeling in cynomolgus monkey ...
Wenhui Zhang +18 more
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Sequence Analysis of APOE Gene Across Mammalian Species in Thailand
Science Technology and Engineering Journal (STEJ), 2021 The current study utilized five mammalian species, including rhesus monkey (Macaca mulatta), Thai Bangkaew dog (Canis lupus familiaris), Thai domestic cat (Felis catus), tiger (Panthera tigris) and Thai domestic rabbit (Oryctolagus cuniculus) to survey ...
Dechawut Bunyaluk +2 more
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Genetic diversity in the env V1-V2 region of proviral quasispecies from long-term controller MHC-typed cynomolgus macaques infected with SHIVSF162P4cy [PDF]
, 2018 Intra-host evolution of human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) has been shown by viral RNA analysis in subjects who naturally suppress plasma viremia to low levels, known as controllers.
Borsetti, Alessandra +11 more
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Occasional essay: upper motor neuron syndrome in amyotrophic lateral sclerosis [PDF]
, 2020 The diagnosis of amyotrophic lateral sclerosis (ALS) requires recognition of both lower (LMN) and upper motor neuron (UMN) dysfunction.1 However, classical UMN signs are frequently difficult to identify in ALS.2 LMN involvement is sensitively detected ...
Burke, David +6 more
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