Results 141 to 150 of about 45,533 (284)
Sleep Research, Volume 3, Issue 3, Page 258-271, September 2026.Abstract Background Insomnia is highly prevalent, and non‐pharmacological strategies to facilitate sleep initiation remain an important clinical priority. Aims This study aimed to evaluate the tolerability, safety, and preliminary sleep‐related effects of a herbal aromatherapy liquid administered using a Traditional Chinese Medicine Aromatherapy Sleep ...
Huafeng Shan +8 more
wiley +1 more source
Acta Anaesthesiologica Scandinavica, Volume 70, Issue 8, September 2026.ABSTRACT Background Hip and knee replacement are common procedures with an increasing focus on same‐day surgery. However, capacity constraints limit the number of eligible patients actually being scheduled for same‐day discharge, calling for further selection of those with the highest likelihood of same‐day discharge.
Christoffer C. Jørgensen +11 more
wiley +1 more source
Exercise or Fasting in Individuals With Type 2 Diabetes Receiving Once‐Weekly Basal Insulin Icodec
Diabetes, Obesity and Metabolism, Volume 28, Issue 9, Page 8523-8532, September 2026.ABSTRACT Aims To investigate glucose levels and hypoglycaemia risk during exercise or fasting in adults with type 2 diabetes (T2D) treated with once‐weekly basal insulin icodec. Materials and Methods Thirty basal insulin‐treated, physically active individuals with T2D (18–75 years, glycated haemoglobin ≤ 75 mmol/mol, peak oxygen uptake > 20 mL/kg/min ...
Thomas R. Pieber +10 more
wiley +1 more source
From Fragments to Function: Novel Hydrazone Derivatives as Monoamine Oxidase Inhibitors
ChemMedChem, Volume 21, Issue 16, 27 August 2026.Twelve N‐acylhydrazone derivatives (5a–f, 6a–f) were synthesized and characterized. Compounds displayed potent submicromolar inhibition against both MAO‐A and MAO‐B. Compound 6e exhibited the strongest activity (IC50 = 0.073 μM for MAO‐A; 0.064 μM for MAO‐B). Kinetic and docking analyses confirmed reversible, competitive inhibition via FAD interaction.
Hasan Erdinç Sellitepe +5 more
wiley +1 more source
ChemMedChem, Volume 21, Issue 16, 27 August 2026.Five novel series of isatin–Schiff base derivatives are synthesized and evaluated for neuroprotective and anti‐infective potential. The compounds demonstrate exceptional, reversible, and competitive monoamine oxidase inhibition, with chloro‐substitutions dictating isoform selectivity.
Marthinus J. Jooste +4 more
wiley +1 more source
Journal of Applied Polymer Science, Volume 143, Issue 32, August 20, 2026.This image is a graphical abstract for outlining the synthesis, characterization, and application of a novel composite material designed to remove toxic pollutants (specifically Methylene Blue dye; MB) from water, and its subsequent use in electrochemical applications.
Rehab Mahmoud +6 more
wiley +1 more source
ChemMedChem, Volume 21, Issue 15, 14 August 2026.Pioglitazone is an antidiabetic drug acting as a peroxisome proliferator‐activated receptor γ (PPARγ) agonist and later repositioned as a monoamine oxidase B (MAO‐B) inhibitor. Despite promising preclinical premises, it showed a lack of efficacy in clinical trials as a treatment for neurodegenerative diseases.
Filippo Basagni +12 more
wiley +1 more source
ChemMedChem, Volume 21, Issue 15, 14 August 2026.We present a set of multifunctional tacrine derivatives, designed with the CADMA‐Chem protocol, aimed for Alzheimer and Parkinson diseases. Of the tacrines designed, TAC‐674 and TAC‐678 are the best candidates to act as multifunctional antioxidants and neuroprotectors for Alzheimer and Parkinson diseases, respectively.
Eugenia Dzib +3 more
wiley +1 more source
Mapping Trofinetide Polypharmacology in Rett Syndrome: A Multi‐Stage Computational Analysis
Journal of Computational Chemistry, Volume 47, Issue 21, August 5, 2026.How can a single molecule address the complex symptoms of Rett syndrome? This computational study maps the multi‐target mechanism of trofinetide, revealing diverse modes of binding across five key receptors: GAT1, GABAA, CHRM1, AMPA, and GSK3β. From deep orthosteric anchoring to dynamic surface interactions, these structural insights provide a rational
Luis Felipe Hernández‐Ayala +2 more
wiley +1 more source
Advanced Synthesis &Catalysis, Volume 368, Issue 15, 1 August 2026.A Goodfellowiella coeruleoviolacea Imine Reductase is here reported as a novel enzyme for biocatalytic application in chiral amine synthesis. Deep eutectic solvents have been used to increase substrate loadings, up to 150 mM, and boost enzymatic activity. Reaction scope and scale‐up procedure showcased the protocol applicability.
Federica De Nardi +5 more
wiley +1 more source