Results 121 to 130 of about 36,956 (236)

Unveiling the Power of Deuterium in Drug Discovery: A Comprehensive Overview

MedComm, Volume 7, Issue 6, June 2026.
The role of deuterium replacement in drug discovery, its progress, opportunities, and challenges. ABSTRACT Deuterium, the heavy isotope of hydrogen, has unfolded as a cornerstone in modern drug discovery due to its potential to influence metabolic stability and pharmacokinetic behavior.
Mukta Lele, Ajit Manchare, Swapnali Parit, Amol D. Gholap, Krishna Jadhav, Navnath Hatvate, Keshav Raj Paudel, Satish Rojekar   +7 more
wiley   +1 more source

Inhibition of monoamine oxidase by fluorobenzyloxy chalcone derivatives. [PDF]

RSC Adv
Sudevan ST, Oh JM, Prabhakaran P, Abdelgawad MA, Ghoneim MM, Al-Serwi RH, Kim H, Mathew B.   +7 more
europepmc   +1 more source

Movement Disorders Associated with 22q11.2 Microdeletion: A Scoping Review

Movement Disorders Clinical Practice, Volume 13, Issue 6, Page 1399-1417, June 2026.
Abstract Background Movement disorders have recently emerged as important neurologic manifestations of the 22q11.2 microdeletion that affects nearly one in every 2000 live births. Objective We aimed to map the existing evidence regarding the spectrum, diagnosis and treatment, and etiopathogenesis of movement disorders associated with 22q11.2 ...
Nikolai Gil D. Reyes, Daniel G. Di Luca, Connie Marras, Erik Boot, Ryan K.C. Yuen, Anthony E. Lang, Anne S. Bassett   +6 more
wiley   +1 more source

Compensatory Serotonin Synthesis and Histone H3 Serotonylation in Preimplantation Embryos Exposed to Maternal Fluoxetine or Monoamine Oxidase Blockade. [PDF]

J Dev Biol
Frolova VS, Nikishin DA.
europepmc   +1 more source

Neuroprotective effects of ursodeoxycholic acid in Parkinson's disease and Alzheimer's disease

Neuroprotection, Volume 4, Issue 2, Page 111-130, June 2026.
In Parkinson's disease (PD) and Alzheimer's disease (AD), various shared pathological mechanisms exist. UDCA has been shown to exert neuroprotective effects in preclinical and clinical studies. Such effects include the mitigation of neuroinflammation as well as rescue effects on mitochondrial dysfunction, oxidative stress, impaired autophagy, and ...
Ashley En Yi Chong, Andrew Octavian Sasmita, Rhun Yian Koh, Anna Pick Kiong Ling   +3 more
wiley   +1 more source

Monoamine Oxidase B in Cancers: Implications for Therapeutics and Prognosis. [PDF]

J Inflamm Res
Liu Y, Li D, Xie C, Pan Y, Shi Q.
europepmc   +1 more source

Japanese Cohort Study Identifies an Association Between the Serotonin Transporter–Linked Polymorphic Region and Suicide Death

Neuropsychopharmacology Reports, Volume 46, Issue 2, June 2026.
The odds ratios and corresponding 95% confidence intervals for suicide death by 5‐HTTLPR S allele, in main and subgroup analyses. Statistical significance is indicated. ABSTRACT Introduction More than 720 000 individuals die by suicide annually worldwide, making it a major public health concern and a leading cause of death among young people ...
Shohei Okada, Toshiyuki Shirai, Masao Miyachi, Gentaro Yamasaki, Kiriko Minami, Ryo Tsukamoto, Kentaro Mouri, Takaki Tanifuji, Ryuichi Katada, Satoshi Okazaki, Ikuo Otsuka, Akitoyo Hishimoto   +11 more
wiley   +1 more source

Association of Preoperative Depression and Clinical Outcomes After Head and Neck Free Flap Reconstruction

Otolaryngology–Head and Neck Surgery, Volume 174, Issue 6, Page 1476-1483, June 2026.
Abstract Objective Comorbid depression is a significant negative predictor of survival in patients with head and neck cancer (HNC). Prior studies have shown a prevalence of up to 40.1%; however, depression is often underdiagnosed in this patient population. Study Design Retrospective cohort. Setting Single‐institution database.
Sindhura Sridhar, Daniel P. Larson, Brooke B. Swain, Heezy Suh, Daniel R. S. Habib, Kelly Vittetoe, Donald Sengstack, Michael C. Topf, Melanie D. Hicks   +8 more
wiley   +1 more source

Monoamine Oxidase B (MAO-B) as an Inducer of Mitochondrial Reactive Oxygen Species (ROS) Production and Myofibroblast Differentiation in Cardiac Fibroblasts of Mice. [PDF]

Cells
Euler G, Disch H, Trautmann M, Bernhardt A, Krechmeier J, Schulz R, Heger J.   +6 more
europepmc   +1 more source

Formulation and Pharmacological Evaluation of a Medicine‐Food Homology Herb‐Based Formula for Sleep Enhancement

Phytochemicals in Food and Medicine, Volume 1, Issue 2, June 2026.
This outlines the progress for developing a sleep‐modulating herbal formula (SMF). It begins with the identification of effective compounds and quality control, then uses network pharmacology and molecular docking to explain the mechanisms behind the observation found on the behavioural and neurobiological results in animal study.
Jasmine U. Ting, Chunxue Zhao, Jia Xu, Chenrui Liu, Yungang Tian, Min Ye, Tao Cui, Jian Huang   +7 more
wiley   +1 more source