Results 111 to 120 of about 186,317 (243)

Application Study of Enzyme Inhibitors and Their Conformational Optimization in The Treatment of Alzheimer’s Disease

Shengwu huaxue yu shengwu wuli jinzhan
Alzheimer’s disease (AD) is a central neurodegenerative disease characterized by progressive cognitive dysfunction and behavioral impairment, and there is a lack of effective drugs to treat AD clinically.
CHU Chao-Yang, XIAO Biao, SHAN Jiang-Hui, CHEN Shi-Yu, ZHANG Chu-Xia, ZHOU Yu-Yu, FANG Tian-Yuan, LIN Zhi-Cheng, XIE Kai, XU Shu-Jun, LI Li-Ping   +10 more
doaj   +1 more source

Raised endogenous monoamine oxidase inhibitor output in postwithdrawal alcoholics: effects of L-dopa and ethanol.

, 1982
Urinary output of endogenous monoamine oxidase inhibitor was significantly greater in a group of postwithdrawal alcoholics than in controls. An oral dose of 0.5 g of L-dopa reduced output to control values in the alcoholics, but in the controls ...
Bhattacharya, S.K., Bernadt, M., Murray, R.M., Glover, V., Sandler, M., Clow, A., Topham, A.   +6 more
core  

Improved Serotonin Measurement With Fast‐Scan Cyclic Voltammetry: Analysis of Electrode Fouling by Fluoxetine in Live Brain Tissue

Analysis &Sensing, Volume 6, Issue 6, November 2026.
Fluoxetine (Prozac) is a drug that is useful for treating depression and for studying serotonin system function in live brain tissue. Unfortunately, the use of fluoxetine tends to foul electrodes when using fast‐scan cyclic voltammetry. In this work, we evaluated an extended serotonin waveform as a useful approach for mitigating fouling by fluoxetine ...
Chase Stucky, Delaney Lounce, Kailash Shrestha, Jing Tian, Ethan Gomez, Heng Du, Kandace Fleming, Michael A. Johnson   +7 more
wiley   +1 more source

The Polymorphism of Monoamine Oxidase-A Gene

Neuropsychiatric Investigation, 2003
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Nurten Erdal, M. Emin Erdal, Handan Çamdeviren, Mahmut Özkaya, Tuba Gökdoğan, Hasan Herken   +5 more
doaj  

A Scalable, Traceable Computational‐to‐Experimental Pipeline for Activity‐Guided Identification of Bioactive Constituents: A Case Study in Salvia miltiorrhiza Bunge

Chemistry &Biodiversity, Volume 23, Issue 11, November 2026.
A scalable, traceable workflow integrating network pharmacology, activity‐guided separation, spectrum–effect analysis, and molecular simulation identifies cryptotanshinone as a major anti–Parkinson's disease constituent of Salvia miltiorrhiza. Its neuroprotective activity is linked to stable MAO‐B interactions, restoration of ATP levels, and enhanced ...
Xin Wang, Zhenghuai Tan, Xiaojie Jin, Jun Hai, Dong Pei, Duo‐Long Di   +5 more
wiley   +1 more source

Design, Synthesis, and Biological Evaluation of Molecular Hybrids Incorporating Coumarin‐Pyrazole‐Linked Indolinone Derivatives With Antioxidant and Anti‐Alzheimer Properties

Chemistry &Biodiversity, Volume 23, Issue 11, November 2026.
ABSTRACT The increase in global life expectancy has resulted in a significant rise in the occurrence of Alzheimer's disease (AD), making it a critical public health burden. Therefore, there is an urgent need to create effective methods to prevent or slow down the progression of the disease.
Ahmed Sabt, Wael Mahmoud Aboulthana, Abdulrahman M. Saleh, Hoda Atef Abdelsattar Ibrahim, Asmaa Saleh, Xinsheng Lei, Aladdin M. Srour   +6 more
wiley   +1 more source

The Role of Astrocytes in the Inflammatory Response in Neurodiseases

MedComm, Volume 7, Issue 11, November 2026.
Reactive astrocyte‐mediated pathogenic mechanisms in neurodegenerative diseases Schematic representation of key astrocytic pathways contributing to pathology in the pathogenesis of AD, PD, ALS, and HD. In AD, astrocytes exhibit Aβ plaque‐associated activation characterized by GFAP/S100β upregulation, accompanied by impaired EAAT2‐mediated glutamate ...
Shijun Peng, Lepeng Wang, Jia Ouyang, Ruen Liu   +3 more
wiley   +1 more source

Efficacy, safety, and patient preference of monoamine oxidase B inhibitors in the treatment of Parkinson's disease

Patient Preference and Adherence, 2011
Bradley J RobottomDepartment of Neurology, University of Maryland School of Medicine, Baltimore, MD, USAAbstract: Parkinson's disease (PD) is the second most common neurodegenerative disease and the most treatable.
Bradley J Robottom
doaj  

Effect of Hydroxytyrosol Derivatives of Donepezil on the Activity of Enzymes Involved in Neurodegenerative Diseases and Oxidative Damage

Molecules
Monoamine oxidase and xanthine oxidase inhibitors represent useful multi-target drugs for the prevention, attenuation, and treatment of oxidative damage and neurodegenerative disorders.
Antonio D’Errico, Rosarita Nasso, Rosario Rullo, Jessica Maiuolo, Paola Costanzo, Sonia Bonacci, Manuela Oliverio, Emmanuele De Vendittis, Mariorosario Masullo, Rosaria Arcone   +9 more
doaj   +1 more source

Neurodegenerative Diseases: Epidemiology, Risk Factors, Classification, Pathophysiology, Clinical Features, Diagnosis, and Therapeutic Strategies

MedComm, Volume 7, Issue 11, November 2026.
Neurodegenerative diseases share convergent risk architectures and pathological mechanisms, yet diverge in selective vulnerability, clinical presentation, and therapeutic responsiveness. This review integrates cross‐disease epidemiology, pathophysiology, diagnosis, and treatment, highlighting the transition from symptomatic care toward biomarker‐guided
Zimeng He, Jingjing Zeng, Guoqing Wang, Yuxin Li, Feng Zhang   +4 more
wiley   +1 more source