Results 101 to 110 of about 817,997 (230)

A new class of powerful inhibitors of monoamine oxidase A

open access: yes, 1990
It is well established that 1-methyl-4-phenylpyridinium (MPP), the neurotoxic bioactivation product of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and most of its analogs are good competitive inhibitors of monoamine oxidase A, with K i values in
Jin, Yuan Zhen   +4 more
core   +1 more source

Intermittent theta‐burst stimulation versus sham stimulation for suicidal ideation and psychiatric symptoms in depressive disorders: A systematic review and meta‐analysis of randomized controlled trials

open access: yesPsychiatry and Clinical Neurosciences Reports, Volume 5, Issue 4, December 2026.
Abstract Suicidal ideation, depressive symptoms, anxiety, and sleep disturbance remain difficult to manage in psychiatric populations, and intermittent theta‐burst stimulation (iTBS) has emerged as an accelerated, non‐invasive neuromodulation strategy for these outcomes.
Muhammad Bilal   +8 more
wiley   +1 more source

Real‐Time Neurochemical Sensing in Zebrafish: Electrochemical and Fluorescent Approaches

open access: yesAnalysis &Sensing, Volume 6, Issue 6, November 2026.
The use of zebrafish has emerged as a powerful approach for real‐time neurochemical measurements. This review highlights recent advances in electrochemical and fluorescent sensing strategies that enable dynamic measurements in live preparations of this complex vertebrate. These complementary approaches provide new insights into neurochemical signaling,
Piyanka Hettiarachchi   +2 more
wiley   +1 more source

Characterizing the Behavior of Caenorhabditis elegans in Monoamine Oxidase Inhibitors

open access: yes
Comparing three different monoamine oxidase inhibitors and the behavioral response of mutant Caenorhabditis elegans. The mutant strain of worm is unable to produce four different modulatory monoamines: serotonin, dopamine, and tyramine ...
Becker, Riley
core   +2 more sources

Improved Serotonin Measurement With Fast‐Scan Cyclic Voltammetry: Analysis of Electrode Fouling by Fluoxetine in Live Brain Tissue

open access: yesAnalysis &Sensing, Volume 6, Issue 6, November 2026.
Fluoxetine (Prozac) is a drug that is useful for treating depression and for studying serotonin system function in live brain tissue. Unfortunately, the use of fluoxetine tends to foul electrodes when using fast‐scan cyclic voltammetry. In this work, we evaluated an extended serotonin waveform as a useful approach for mitigating fouling by fluoxetine ...
Chase Stucky   +7 more
wiley   +1 more source

A Scalable, Traceable Computational‐to‐Experimental Pipeline for Activity‐Guided Identification of Bioactive Constituents: A Case Study in Salvia miltiorrhiza Bunge

open access: yesChemistry &Biodiversity, Volume 23, Issue 11, November 2026.
A scalable, traceable workflow integrating network pharmacology, activity‐guided separation, spectrum–effect analysis, and molecular simulation identifies cryptotanshinone as a major anti–Parkinson's disease constituent of Salvia miltiorrhiza. Its neuroprotective activity is linked to stable MAO‐B interactions, restoration of ATP levels, and enhanced ...
Xin Wang   +5 more
wiley   +1 more source

The organometallic route to benzylamine type monoamine oxidase inhibitors

open access: yes
N-Methyl-N-(2-propynyl)piperonylamine can be simultaneously lithiated at the terminal acetylenic and at that arom. position which is flanked by both the side chain and an oxygen atom. Under carefully established conditions, the metal occupying the latter
Schlosser, Manfred, Geneste, Herve
core   +1 more source

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