Results 91 to 100 of about 817,997 (230)

Intramuscular pathways of maladaptation in overtraining syndrome

The Journal of Physiology, EarlyView.
Abstract figure legend The transition from adaptive overreaching to maladaptive overtraining and mechanisms through which excessive training load can lead to performance decline. Four interconnected pathophysiological domains are highlighted: neural fatigue, involving both central and peripheral components such as altered sensory feedback and reflex ...
Emily Shorter, Oscar Horwath, Sabrina Tzivia Barsky, Ferdinand von Walden, Johanna T. Lanner   +4 more
wiley   +1 more source

The synthesis and evaluation of C7-substituted α-tetralone derivatives as inhibitors of monoamine oxidase

, 2015
Based on a previous report that α-tetralone (3,4-dihydro-2H-naphthalen-1-one) is a promising scaffold for the design of highly potent inhibitors of the enzyme, monoamine oxidase, the present study investigates the monoamine oxidase inhibitory properties ...
Petzer, Jacobus P., Anél Petzer, Lesetja J. Legoabe, Jacobus P. Petzer, Legoabe, Lesetja J., Petzer, Anél   +5 more
core   +1 more source

Cannabinoid exposure during pregnancy: Cardiorespiratory effects and offspring outcomes

The Journal of Physiology, EarlyView.
Abstract figure legend Prenatal exposure to cannabinoids has been investigated across human and animal studies to understand its impact on physiological development. Evidence suggests that early‐life cannabinoid exposure influence multiple developmental processes, extending beyond neurodevelopmental outcomes to potentially affect placental function ...
Luis Gustavo A. Patrone, Luciane H. Gargaglioni   +1 more
wiley   +1 more source

Design, Synthesis and Biological Evaluation of Novel N-Pyridyl-Hydrazone Derivatives as Potential Monoamine Oxidase (MAO) Inhibitors

Molecules, 2018
A new series of N-pyridyl-hydrazone derivatives was synthesized by using a simple and efficient method. The final compounds obtained were screened for their inhibitory potency against monoamine oxidase (MAO) A and B. The newly synthesized compounds 2a–2n
Gülhan Turan-Zitouni, Weiam Hussein, Begüm Nurpelin Sağlık, Aouatef Tabbi, Büşra Korkut   +4 more
doaj   +1 more source

Maternal nutrition as a key determinant of placental and developing blood–brain barrier xenobiotic protective functions

The Journal of Physiology, EarlyView.
Abstract figure legend Suboptimal maternal nutrition alters placental and developing blood–brain barrier (BBB) protective function and is associated with increased fetal brain vulnerability. In the placenta, nutritional adversity may reduce the exchange surface area and promote meta‐inflammation, compromising barrier efficiency in a model‐ and context ...
Kristin L. Connor, Nycolle I. S. Souza, Bruno G. Anjos, Stephen G. Matthews, Enrrico Bloise   +4 more
wiley   +1 more source

Cerebellar Abnormalities in the Neuroimaging Spectrum of CLTC‐Related Disorder

American Journal of Medical Genetics Part A, Volume 200, Issue 12, Page 2601-2607, December 2026.
ABSTRACT Pathogenic variants in CLTC, which encodes the clathrin heavy chain involved in vesicle‐mediated trafficking in neurons, cause a rare neurodevelopmental disorder associated with variable severity of global developmental delay and intellectual disability and structural brain abnormalities. Although corpus callosum and white matter anomalies are
Daniel Charouf, Andrea Accogli, Fadi F. Hamdan, Francesca Nardecchia, Toshiyuki Itai, Kenneth A. Myers, Christine Saint Martin, Myriam Srour   +7 more
wiley   +1 more source

Aporphine Alkaloids from (Annonaceae)

Natural Product Communications, 2008
Guatteria species (Annonaceae) are rich in isoquinoline alkaloids that contain a restricted β-phenethylamine moiety and thus have potential as monoamine oxidase (MAO) inhibitors for the treatment of Alzheimer's and Parkinson's diseases.
María Rodríguez, Elsy Bastidas, Mildred Rodríguez, Edgar Lucena, Anibal Castillo, Masahisa Hasegawa   +5 more
doaj   +1 more source

Monoamine Oxidase Isoform-Dependent Tautomeric Influence in the Recognition of 3,5-Diaryl Pyrazole Inhibitors

, 2016
A series of 3,5-diaryl pyrazoles were prepared and assayed for their ability to inhibit reversibly monoamine oxidase-A (MAO-A) and monoamine oxidase B (MAO-B). Several compounds show inhibitory activity with concentration values in the nanomolar range. A
Franco Chimenti (2268034), Francesco Ortuso (480669), Paola Chimenti (805165), Daniela Secci (1456555), Rossella Fioravanti (2100034), Olivia Befani (2501338), Stefano Alcaro (152511), Paola Turini (2501341), Adriana Bolasco (2100031), Fedele Manna (2506414)   +9 more
core   +1 more source

Integrated Phytochemical Characterisation, Pharmacological Evaluation and Computational Investigation of Acampe papillosa Stem Extract

Analytical Science Advances, Volume 7, Issue 2, December 2026.
The pharmacological potential of the methanolic stem extract of Acampe papillosa is evaluated using in vivo and in silico approaches. The extract demonstrates significant anxiolytic, sedative, anti‐inflammatory, and antipyretic activities in experimental models, while molecular docking supports the observed biological effects through favorable ...
Qurratul Ain Sadia, Sadia Tamanna Tamim, Faruq Mohammed Tashriq, Nasir Uddin, Fatematus Zhohara Alam Hima, Ulfat Sobha Surat, Mily Khastagir, Muhammad Abdul Jalil, Md. Hossain Rasel, Arman Ullah Rafi, S. M. Moazzem Hossen   +10 more
wiley   +1 more source

Mucuna pruriens as a Sustainable Functional Food: Applications From Seed to Product

Modern Agriculture, Volume 4, Issue 2, December 2026.
This review highlights Mucuna pruriens as a nutrient‐rich legume with significant nutritional, therapeutic, and agricultural value. Its protein‐rich seeds contain essential minerals and L‐DOPA, but high antinutritional compounds require effective processing before consumption.
Crossby Osei Tutu, Reuben Acheampong, Papa Toah Akonor, Bernard Kwabena Asiedu, Rexford Obeng, Anthonia Helga Andoh‐Odoom, Dora Duah‐Bisiw, Jacob Ulzen, Michael Wiafe‐Kwagyan, Nii Korley Kortei, Justice Owusu‐Bempah   +10 more
wiley   +1 more source