Results 91 to 100 of about 25,878 (248)

Efficacy, safety, and patient preference of monoamine oxidase B inhibitors in the treatment of Parkinson's disease

Patient Preference and Adherence, 2011
Bradley J RobottomDepartment of Neurology, University of Maryland School of Medicine, Baltimore, MD, USAAbstract: Parkinson's disease (PD) is the second most common neurodegenerative disease and the most treatable.
Bradley J Robottom
doaj  

The synthesis and evaluation of C7-substituted α-tetralone derivatives as inhibitors of monoamine oxidase

, 2015
Based on a previous report that α-tetralone (3,4-dihydro-2H-naphthalen-1-one) is a promising scaffold for the design of highly potent inhibitors of the enzyme, monoamine oxidase, the present study investigates the monoamine oxidase inhibitory properties ...
Petzer, Jacobus P., Anél Petzer, Lesetja J. Legoabe, Jacobus P. Petzer, Legoabe, Lesetja J., Petzer, Anél   +5 more
core   +1 more source

Endothelium‐ and epithelium‐derived novel endogenous catecholamines as modulators of the autonomic nervous system

British Journal of Pharmacology, EarlyView.
Abstract Catecholamines are classically viewed as neuronal transmitters and adrenal hormones; however, accumulating evidence demonstrates that sources other than nerve fibres and adrenal medulla play a fundamental role in local organ regulation. Physiological paradoxes, such as preserved organ function after denervation or transplantation, challenge a ...
Mariana G. de Oliveira, Edson Antunes, Fabiola Zakia Monica, Gilberto De Nucci   +3 more
wiley   +1 more source

Effectiveness of galcanezumab versus topiramate, amitriptyline, and other select traditional oral migraine preventives with evidence of efficacy: 3‐Month results from the TRIUMPH study

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objective To compare the 3‐month effectiveness of galcanezumab with select traditional oral migraine preventive (TOMP) medications recommended by scientific societies (TOMP efficacy subset) and with the most frequently used individual TOMP medications.
Shivang Joshi, Cristina Tassorelli, Manjit Matharu, Taoufik Alsaadi, Carlos Vallarino, Lars Viktrup, Maurice Vincent, Rebecca L. Robinson   +7 more
wiley   +1 more source

Targeting MAO-B with Small-Molecule Inhibitors: A Decade of Advances in Anticancer Research (2012–2024)

Molecules
Monoamine oxidase B (MAO-B) is a key enzyme in the mitochondrial outer membrane, pivotal for the oxidative deamination of biogenic amines. Its overexpression has been implicated in the pathogenesis of several cancers, including glioblastoma and ...
Iyman Alsaad, Diana M. A. Abdel Rahman, Ola Al-Tamimi, Shayma’a A. Alhaj, Dima A. Sabbah, Rima Hajjo, Sanaa K. Bardaweel   +6 more
doaj   +1 more source

Serotonin uptake via plasma membrane monoamine transporter during myocardial ischemia‐reperfusion in the rat heart in vivo

Physiological Reports, 2019
Serotonin (5‐HT) accumulates in the heart during myocardial ischemia and induces deleterious effects on the cardiomyocytes through receptor‐dependent and monoamine oxidase‐dependent pathways.
Takashi Sonobe, Tsuyoshi Akiyama, Cheng‐Kun Du, James T. Pearson   +3 more
doaj   +1 more source

Do Genetics Shape Mental Health Trajectories Around Partnership Transitions?

Journal of Marriage and Family, EarlyView.
ABSTRACT Objective This study focuses on the extent to which genetic risk for mental disorders contributes to observed mental health problems before and after partnership transitions. Background Partnership formation and dissolution are linked to short‐term changes in mental health, with outcomes varying by gender, socioeconomic position, and other ...
Philipp Dierker, Maria Gueltzow, Hannu Lahtinen, Mine Kühn, Pekka Martikainen, Mikko Myrskylä   +5 more
wiley   +1 more source

Coumarins derivatives as dual inhibitors of acetylcholinesterase and monoamine oxidase

, 2001
A set of 17 coumarin and 2 chromone derivatives with known inhibitory activity toward monoamine oxidase (MAO) A and B were tested as acetylcholinesterase (AChE) inhibitors.
Testa, Bernard, Carotti, Angelo, Leonetti, Francesco, Catto, M., Leonetti, F., Ooms, Frédéric, Carrupt, Pierre-Alain, Ooms, F., Bruhlmann, C., Brühlmann, Corinne, Altomare, Cosimo, Catto, Marco   +11 more
core   +2 more sources

Expression regulation of MAO isoforms in monocytic cells in response to Th2 cytokines

, 2005
Background: Th2-cytokines, such as interleukins-4 and –13 (IL-4, IL-13), have been identified as alternative stimuli of monocytes/macrophages. We have recently profiled the gene-expression pattern of IL-4-teated human peripheral monocytes and found that ...
Kuban, RJ, Billett, E, Kuhn, H, Chaitidis, P, Ungethuem, U   +4 more
core  

Correlation between monoamine oxidase mRNA expression and enzymatic activity in rat tissues [PDF]

, 2004
Monoamine oxidase A and B (MAO-A and -B, EC 1.4.3.4) are the major enzymes that catalyze the oxidative deamination of neurotransmitters, peripheral vasoactive amines and xenobiotics. MAO-A and -B can be distinguished by difference in substrate preference
サクライ, エイイチ, Tanaka, Yorihisa, 伊藤, 邦郎, Sakurai, Eiichi, イトウ, クニオ, 田中, 頼久, 櫻井, 栄一, オチアイ, ヨシノリ, タナカ, ヨリヒサ, 駒井, 理恵, コマイ, リエ, Itoh, Kunio, Komai, Rie, 落合, 義徳, Ochiai, Yoshinori   +14 more
core