Results 91 to 100 of about 23,408 (219)

Satellite Glial Cells Synthesize and Release GABA to Activate Extrasynaptic GABAA Receptors That Modulate Dorsal Root Ganglia Neuron Excitability

Glia, Volume 74, Issue 9, September 2026.
Mechanism of synthesis, release, receptor activation, uptake, and degradation of GABA in dorsal root ganglia (DRG). Left: GABA is synthesized from putrescine in satellite glial cells (SGCs). After being released by Best1 channel, it activates GABAA receptors in sensory neurons, producing a chloride current.
Natalie Jiménez‐Barrios, Ricardo González‐Ramírez, Francisco Javier Paz‐Bermúdez, Guadalupe Raya‐Tafolla, José Segovia Vila, Ricardo Felix, Rodolfo Delgado‐Lezama, Benjamín Florán Garduño   +7 more
wiley   +1 more source

An open‐label, long‐term extension, multicenter study to evaluate the safety and efficacy of venlafaxine extended release in Japanese outpatients with generalized anxiety disorder

Psychiatry and Clinical Neurosciences Reports, Volume 5, Issue 3, September 2026.
Abstract Aim This study evaluated the long‐term safety and efficacy of venlafaxine extended release (ER), which has been administered for 52 weeks in Japanese adult outpatients with generalized anxiety disorder (GAD). Methods In this open‐label, long‐term extension, multicenter study, 135 Japanese patients with GAD were enrolled after completing 10 ...
Tempei Otsubo, Koichiro Watanabe, Takeshi Inoue, Ataru Inagaki, Toshiaki Kikuchi, Keisuke Nomoto, Shingo Higa, Yuko Asami, Bin Sun, Kristina Marschall   +9 more
wiley   +1 more source

Safety comparisons among monoamine oxidase inhibitors against Parkinson's disease using FDA adverse event reporting system. [PDF]

Sci Rep, 2023
Asano H, Tian YS, Hatabu A, Takagi T, Ueda M, Ikeda K.   +5 more
europepmc   +1 more source

Molecular Mechanisms of Food Bioactive Constituents in the Management of Obesity and Hypertension: A Critical Review

Phytochemicals in Food and Medicine, Volume 1, Issue 3, September 2026.
Obesity and hypertension co‐exist and share molecular mechanisms in terms of dietary therapy, modulated by food bioactive constituents. ABSTRACT Obesity and hypertension are among the most pressing global public health challenges. They frequently co‐exist, with obesity‐related hypertension accounting for an estimated 75% of the hypertension burden ...
Samuel Oluwasegun Maccarthy, Emmanuel Anyachukwu Irondi, Abdulazeez Olamilekan Elemosho, Emmanuel Oladipo Ajani   +3 more
wiley   +1 more source

In Vitro Evaluation of Novel Furo[3,2-c]coumarins as Cholinesterases and Monoamine Oxidases Inhibitors

Molecules
Coumarin represents a privileged structural motif that is quite common in nature-derived and synthetic bioactive molecules. Some of us have recently described the straightforward preparation of complex furo[3,2-c]coumarins through a sequential double ...
Mariagrazia Rullo, Alice Benzi, Lara Bianchi, Massimo Maccagno, Guglielmo Marcantoni Taddei, Daniela Valeria Miniero, Giuseppe Felice Mangiatordi, Giovanni Lentini, Leonardo Pisani, Giovanni Petrillo, Cinzia Tavani   +10 more
doaj   +1 more source

Exploration of the Detailed Structure-Activity Relationships of Isatin and Their Isomers As Monoamine Oxidase Inhibitors. [PDF]

ACS Omega, 2022
Kumar S, Nair AS, Abdelgawad MA, Mathew B.   +3 more
europepmc   +1 more source

Application of Physiologically Based Pharmacokinetic Modeling to Optimize Assessment of Age‐Related Fluoxetine Accumulation in the Elderly

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 9, September 2026.
ABSTRACT This study quantified age‐related differences in fluoxetine pharmacokinetics and evaluated the influence of CYP2D6 phenotype using physiologically based pharmacokinetic (PBPK) modeling integrated with clinical therapeutic drug monitoring data.
Yoo Jin Jang, Dong‐Gyu Heo, Eunjin Hong   +2 more
wiley   +1 more source

Getting the balance right: Established and emerging therapies for major depressive disorders

Neuropsychiatric Disease and Treatment, 2010
Bojana Perovic, Marija Jovanovic, Branislava Miljkovic, Sandra VezmarDepartment of Pharmacokinetics, Faculty of Pharmacy, University of Belgrade, SerbiaAbstract: Major depressive disorder (MDD) is a common and serious illness of our times, associated ...
Bojana Perovic, Marija Jovanovic, Branislava Miljkovic, et al   +3 more
doaj  

Efficacy and safety of traditional Chinese medicine aromatherapy for insomnia patients with predominant difficulty in sleep initiation

Sleep Research, Volume 3, Issue 3, Page 258-271, September 2026.
Abstract Background Insomnia is highly prevalent, and non‐pharmacological strategies to facilitate sleep initiation remain an important clinical priority. Aims This study aimed to evaluate the tolerability, safety, and preliminary sleep‐related effects of a herbal aromatherapy liquid administered using a Traditional Chinese Medicine Aromatherapy Sleep ...
Huafeng Shan, Chun Wang, Dengyi Cao, Yi Long, Xiaowei Huang, Jiayang Meng, Zhongxia Shen, Xiaomei Zhang, Qinjuan Ren   +8 more
wiley   +1 more source

Screening of Monoamine Oxidase Inhibitors from Seeds of Nigella glandulifera Freyn et Sint. by Ligand Fishing and Their Neuroprotective Activity. [PDF]

Plants (Basel), 2023
Ayeni EA, Ma C, Hu Y, Bai X, Zhang Y, Liao X.   +5 more
europepmc   +1 more source