Results 111 to 120 of about 23,408 (219)
ChemMedChem, Volume 21, Issue 15, 14 August 2026.Pioglitazone is an antidiabetic drug acting as a peroxisome proliferator‐activated receptor γ (PPARγ) agonist and later repositioned as a monoamine oxidase B (MAO‐B) inhibitor. Despite promising preclinical premises, it showed a lack of efficacy in clinical trials as a treatment for neurodegenerative diseases.
Filippo Basagni +12 more
wiley +1 more source
ChemMedChem, Volume 21, Issue 15, 14 August 2026.We present a set of multifunctional tacrine derivatives, designed with the CADMA‐Chem protocol, aimed for Alzheimer and Parkinson diseases. Of the tacrines designed, TAC‐674 and TAC‐678 are the best candidates to act as multifunctional antioxidants and neuroprotectors for Alzheimer and Parkinson diseases, respectively.
Eugenia Dzib +3 more
wiley +1 more source
Mapping Trofinetide Polypharmacology in Rett Syndrome: A Multi‐Stage Computational Analysis
Journal of Computational Chemistry, Volume 47, Issue 21, August 5, 2026.How can a single molecule address the complex symptoms of Rett syndrome? This computational study maps the multi‐target mechanism of trofinetide, revealing diverse modes of binding across five key receptors: GAT1, GABAA, CHRM1, AMPA, and GSK3β. From deep orthosteric anchoring to dynamic surface interactions, these structural insights provide a rational
Luis Felipe Hernández‐Ayala +2 more
wiley +1 more source
Monoamine Oxidase Inhibitors: A Review of Their Anti-Inflammatory Therapeutic Potential and Mechanisms of Action. [PDF]
Front Pharmacol, 2021 Ostadkarampour M, Putnins EE.
europepmc +1 more source
Advanced Synthesis &Catalysis, Volume 368, Issue 15, 1 August 2026.A Goodfellowiella coeruleoviolacea Imine Reductase is here reported as a novel enzyme for biocatalytic application in chiral amine synthesis. Deep eutectic solvents have been used to increase substrate loadings, up to 150 mM, and boost enzymatic activity. Reaction scope and scale‐up procedure showcased the protocol applicability.
Federica De Nardi +5 more
wiley +1 more source
Chromenone Derivatives as Monoamine Oxidase Inhibitors from Marine-Derived MAR4 Clade Streptomyces sp. CNQ-031. [PDF]
J Microbiol Biotechnol, 2021 Oh JM, Lee C, Nam SJ, Kim H.
europepmc +1 more source
Advanced Science, Volume 13, Issue 43, 3 August 2026.An electrochemical platform based on differential pulse amperometry enables real‐time, selective tracking of safinamide pharmacokinetics in the living brain with high spatiotemporal resolution. When integrated with electrophysiology, this approach reveals that drug‐induced suppression of vision‐related neuronal activity provides mechanistic insight ...
Xiaoke Nan +9 more
wiley +1 more source
Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.Abstract INTRODUCTION Neuroimaging studies report associations of amyloid beta (Aβ) positron emission tomography (PET) with [18F](S)‐(2‐methylpyrid‐5‐yl)‐6‐[(3‐fluoro‐2‐hydroxy)propoxy]quinoline ([18F]SMBT‐1), a novel reactive astrogliosis surrogate radiotracer with high affinity for monoamine oxidase B (MAO‐B) in Alzheimer's disease (AD).
Eric E. Abrahamson +9 more
wiley +1 more source
Clinical Case Reports, Volume 14, Issue 8, August 2026.ABSTRACT Acute encephalopathy in patients with prolonged isotretinoin exposure should prompt careful assessment of undisclosed or non‐prescribed medication use. This case suggests a possible association between high cumulative isotretinoin exposure, frequent daily rizatriptan use, and acute encephalopathy, but does not establish a definitive drug–drug ...
Soheil Roshanzamiri +5 more
wiley +1 more source