Quercetin and Related Chromenone Derivatives as Monoamine Oxidase Inhibitors: Targeting Neurological and Mental Disorders [PDF]
Molecules, 2019 Monoamine oxidase inhibitions are considered as important targets for the treatment of depression, anxiety, and neurodegenerative disorders, including Alzheimer’s and Parkinson’s diseases.
Priyanka Dhiman +4 more
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Molecules, 2021 Despite not being utilized as considerably as other antidepressants in the therapy of depression, the monoamine oxidase inhibitors (MAOIs) proceed to hold a place in neurodegeneration and to have a somewhat broad spectrum in respect of the treatment of ...
Tapan Behl +9 more
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Amphetamine Derivatives as Monoamine Oxidase Inhibitors [PDF]
Frontiers in Pharmacology, 2020 Amphetamine and its derivatives exhibit a wide range of pharmacological activities, including psychostimulant, hallucinogenic, entactogenic, anorectic, or antidepressant effects.
Miguel Reyes-Parada +3 more
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Effects of Natural Monoamine Oxidase Inhibitors on Anxiety-Like Behavior in Zebrafish [PDF]
Frontiers in Pharmacology, 2021 Monoamine oxidases (MAO) are a valuable class of mitochondrial enzymes with a critical role in neuromodulation. In this study, we investigated the effect of natural MAO inhibitors on novel environment-induced anxiety by using the zebrafish novel tank ...
Oihane Jaka +8 more
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Natural based piperine derivatives as potent monoamine oxidase inhibitors: an in silico ADMET analysis and molecular docking studies [PDF]
BMC Chemistry, 2020 Neurodegenerative disorders follow numerous pathological ways concerning overexpression of monoamine oxidase and formation of reactive oxygen species.
Priyanka Dhiman +2 more
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Monoamine Oxidase Inhibitors in Drug Discovery Against Parkinson’s Disease: An Update [PDF]
PharmaceuticalsBackground: Parkinson’s disease (PD) is a progressive neurodegenerative disorder with substantial socioeconomic impact, characterized by the gradual loss of dopaminergic neurons, dopamine deficiency, and pathological processes such as neuroinflammation ...
Luana Vergueiro Ribeiro +3 more
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2-acetylphenol analogs as potent reversible monoamine oxidase inhibitors [PDF]
Drug Design, Development and Therapy, 2015 Lesetja J Legoabe,1 Anél Petzer,1 Jacobus P Petzer1,21Centre of Excellence for Pharmaceutical Sciences, 2Department of Pharmaceutical Chemistry, School of Pharmacy, North-West University, Potchefstroom, South AfricaAbstract: Based on a previous ...
Legoabe LJ, Petzer A, Petzer JP
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Piperidine: A Versatile Heterocyclic Ring for Developing Monoamine Oxidase Inhibitors [PDF]
ACS Omega, 2023 Jayalakshmi Jayan +11 more
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Journal of Enzyme Inhibition and Medicinal Chemistry, 2020 The inhibition of monoamine oxidase B (MAO-B) could be an effective approach for the treatment of various neurological disorders. In this study, a series of 1, 4-benzodioxan-substituted chalcone derivatives were designed, synthesised and evaluated for ...
Zhuo Kong +3 more
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Treating hearts and minds: adverse cardiovascular effects of psychiatric medications [PDF]
Therapeutic Advances in Drug SafetyCardiovascular disease (CVD) is one of the leading causes of death in patients with severe mental illness (SMI), being ~3.3 times higher than in the general population.
Asdaq Shabbir Raja +5 more
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