Results 31 to 40 of about 817,997 (230)

Platelet monoamine oxidase activity in alcoholics with and without a family history of alcoholism [PDF]

, 2000
A number of studies point at platelet monoamine oxidase (MAO) activity being reduced in alcoholics with a family history of drinking, this being a possible vulnerability marker for alcoholism.
Bondy, Brigitta, Preuss, Ulrich W., Soyka, Michael, Hegerl, Ulrich, Benda, Ellen, Möller, Hans-Jürgen, Brigitta Bondy, Ulrich Preuss, Michael Soyka, Ellen Benda, Hans-Jürgen Möller, Ulrich Hegerl   +11 more
core   +1 more source

PYRAZOLINES WITH ANTICONVULSANT AND MAO INHIBITORY ACTIVITIES [PDF]

Al-Azhar Journal of Pharmaceutical Sciences, 2014
2-Pyrazolines (4,5-dihydro-1H-pyrazole) are an important class of five-membered heterocyclic compounds and were found to be vital building block in medicinal chemistry and led to the discovery of a number of bioactive derivatives.
Mohamed Aboul-Enein
doaj   +1 more source

Development of Novel Fluorine-18 Labeled PET Radioligands for Monoamine Oxidase B (MAO-B) [PDF]

, 2013
Monoamine oxidases (MAO-A and MAO-B) are important enzymes regulating the levels of monoaminergic neurotransmitters. Selective and irreversible MAO-B inhibitors such as L-deprenyl and rasagiline are clinically used for the treatment of psychiatric and ...
Nag, Sangram
core   +1 more source

Structure-Activity Relationship Analysis of 3-Phenylcoumarin-Based Monoamine Oxidase B Inhibitors

Frontiers in Chemistry, 2018
Monoamine oxidase B (MAO-B) catalyzes deamination of monoamines such as neurotransmitters dopamine and norepinephrine. Accordingly, small-molecule MAO-B inhibitors potentially alleviate the symptoms of dopamine-linked neuropathologies such as depression ...
Sanna Rauhamäki, Pekka A. Postila, Sanna Niinivehmas, Sami Kortet, Sami Kortet, Emmi Schildt, Emmi Schildt, Mira Pasanen, Elangovan Manivannan, Elangovan Manivannan, Mira Ahinko, Pasi Koskimies, Niina Nyberg, Pasi Huuskonen, Elina Multamäki, Markku Pasanen, Risto O. Juvonen, Hannu Raunio, Juhani Huuskonen, Olli T. Pentikäinen, Olli T. Pentikäinen   +20 more
doaj   +1 more source

Concentration of norepinephrine, serotonin, and histamine, and of amine-metabolizing enzymes in mammalian adipose tissue

Journal of Lipid Research, 1963
The norepinephrine content of adipose tissue is shown to be very different in various animal species and different sites of origin, ranging from 0.03-1.4 μg/g. Adipose tissue also contains considerable amounts of serotonin (0.01-1.04 μg/g) and histamine (
K. Stock, E.O. Westermann
doaj   +1 more source

Monoamine oxidase in neuronal cell death [PDF]

, 2008
Monoamine oxidase (MAO) is an oxidative enzyme that deaminates a variety of amine substrates, including the neurotransmitter dopamine. The enzymatic reaction requires molecular oxygen and produces hydrogen peroxide as a by-product.
Fitzgerald, J
core  

Cost-effectiveness of dopamine agonists and monoamine oxidase B inhibitors in Parkinson’s disease [PDF]

, 2021
Background: The PD MED study reported small but persistent benefits in patient‐rated mobility scores and quality of life from initiating therapy with levodopa compared with levodopa‐sparing therapies in early Parkinson's disease (PD).
Emma McIntosh, Kent, Seamus, Wheatley, Keith, Rick, Caroline, Caroline Rick, Gray, Alastair, Ives, Natalie, Williams, Adrian, Richard Gray, Gray, Richard, Patel, Smitaa, PD MED Collaborative Group, Seamus Kent, McIntosh, Emma, Keith Wheatley, Smitaa Patel, Carl E. Clarke, Natalie Ives, Alastair Gray, Crispin Jenkinson, Adrian Williams, Clarke, Carl E., Jenkinson, Crispin, al., Et, Gray, R, Kent, S, McIntosh, E, Jenkinson, C, Clarke, Carl   +28 more
core   +1 more source

Modulation of the TGF‐β/Smad Signaling Pathway by a Bioactive Oxidized Polygonati Rhizoma Polysaccharide Crosslinked Chitosan Hydrogel as Therapeutic Carrier for Parkinson's Disease Treatment

Advanced Science, EarlyView.
An injectable, self‐healing COPRP hydrogel integrates structurally defined oxidized Polygonati rhizoma polysaccharide with carboxymethyl chitosan through dynamic Schiff‐base crosslinking. The bioactive matrix scavenges reactive oxygen species, suppresses neuroinflammation, protects dopaminergic neurons, and supports sustained levodopa release.
Peng Dai, Jikuang Zhao, Chang Xue, Kailei Xu, Liang Yong, Zhuangwei Zhang, Yi Huang, Jianwei Shuai, Xianzhen Chen, Sheng Nie, Junpeng Xu   +10 more
wiley   +1 more source

Amyloid‐Guided Assembly of Magnetically Recyclable Enzymatic Nanofibers Toward Sustainable Biocatalysis

Advanced Science, EarlyView.
A hierarchical strategy integrates linker engineering, amyloid‐guided self‐assembly, and magnetic immobilization to construct recyclable DPAO4‐DMAO7 enzymatic nanofibers. The resulting magnetic composites enable biogenic amine conversion in complex food matrices and simulated wastewater, while rapid magnetic separation supports repeated reuse. The work
Shuangping Liu, Qilin Yang, Qian Zhang, Tiantian Liu, Xiao Han, Jian Mao   +5 more
wiley   +1 more source

Probiotic spore‐based bioresponsive drug delivery for reversing inflammatory bowel disease and its associated anxiety and depression

BMEMat, EarlyView.
A probiotic spore‐based drug delivery system (BCS‐Que@ApNPs) provides excellent targeted delivery, bioresponsive drug release, and long‐term retention (over 48 h), making it suitable for oral treatment of inflammatory bowel disease and its associated anxiety and depression.
Qingling Song, Beiyang Xue, Yao Li, Chuangxi Zhou, Junfei Yang, Yunfei Li, Lingwen Ding, Yun Zhang, Hongjuan Zhao, Lei Wang   +9 more
wiley   +1 more source