Results 41 to 50 of about 817,997 (230)
Epilepsia, EarlyView.Abstract Anti‐seizure medication (ASM) discovery remains a major challenge despite over 30 commercially available options. One persistent obstacle for any promising candidate compound to successfully move from preclinical study to clinical approval has been the ambiguity in preclinical model selection.
Wolfgang Löscher +1 more
wiley +1 more source
Pharmacological ResearchIn the 1950s, monoamine oxidase inhibitors transformed the pharmacological treatment of mental disorders as the first class of antidepressant drugs.
Larissa Junkes +4 more
doaj +1 more source
Ketogenic diet for infantile epileptic spasms
Epilepsia Open, EarlyView.Abstract Approximately half of all cases of Infantile Epileptic Spasms Syndrome (IESS) do not respond to vigabatrin and hormonal therapies. There is no clear consensus as to the second‐line therapy for IESS. Ketogenic diet (KD) has emerged as an effective treatment for certain drug‐resistant epilepsies and in many cases of IESS.
Morris H. Scantlebury +3 more
wiley +1 more source
Monoamine Oxidase-B Inhibitors for the Treatment of Parkinson’s Disease: Past, Present, and Future
Journal of Parkinson’s Disease, 2022 Monoamine oxidase-B (MAO-B) inhibitors are commonly used for the symptomatic treatment of Parkinson’s disease (PD). MAO-B inhibitor monotherapy has been shown to be effective and safe for the treatment of early-stage PD, while MAO-B inhibitors as ...
Yu-Yan Tan, Peter Jenner, Sheng-Di Chen
doaj +1 more source
, 2021 The purpose of this project was to design and synthesize monoamine oxidase inhibitors. Ten monoamine oxidase inhibitors were designed using molecular docking and synthesized.
O\u27Connor, Paige +2 more
core +1 more source
Baroreflex Failure After Surgical Resection of Bilateral Carotid Body Tumors: A Systematic Review
The Laryngoscope, EarlyView.ABSTRACT Objective Surgery remains the definitive treatment for carotid body tumors (CBTs); however, concern persists regarding the risk of baroreflex failure (BRF) following bilateral CBT resection. The true incidence and long‐term clinical course of BRF remain poorly defined. We performed a systematic review to examine the risk and clinical course of
Alex Z. Graboyes +8 more
wiley +1 more source
Movement Disorders, EarlyView.Abstract Background There is a lack of treatments for non‐motor symptoms (NMS) in Parkinson's disease (PD). Objective To assess the safety and effectiveness of an oral Cannabis sativa L. extract on pain and other NMS of PD. Methods This phase II, randomized, placebo‐controlled trial evaluated a formulation containing cannabidiol (CBD; 96 mg/ml) and Δ9 ...
Gabriel T. Kubota +14 more
wiley +1 more source
Interaction between histamine and monoamine oxidase inhibitors
, 1969 The monoamine oxidase inhibitors tranylcypromine, nialamide and iproniazid potentiated the actions of histamine on the blood pressure of the cat and on the tracheo-bronchial muscle of the guinea-pig.
G S Allen, M J Rand
core +1 more source
Apathy in Lewy Body Disorders: A Position Paper
Movement Disorders, EarlyView.Abstract Apathy is one of the most prevalent and disabling non‐motor symptoms in Parkinson's disease (PD) and dementia with Lewy bodies (DLB), collectively referred to as Lewy body disorders (LBDs). It is associated with reduced quality of life, accelerated cognitive decline, increased caregiver burden, and poorer functional outcomes, yet remains ...
Jaime Kulisevsky +12 more
wiley +1 more source
Interaction between phenylpropanolamine and monoamine oxidase inhibitors
, 1969 The role of monoamine oxidase in the potentiation of the pressor effect of phenylpropanolamine (norephedrine) by monoamine oxidase inhibitors has been investigated.
A D’Mello
core +1 more source