Results 21 to 30 of about 25,878 (248)

Design, synthesis, and evaluation of 1, 4-benzodioxan-substituted chalcones as selective and reversible inhibitors of human monoamine oxidase B

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
The inhibition of monoamine oxidase B (MAO-B) could be an effective approach for the treatment of various neurological disorders. In this study, a series of 1, 4-benzodioxan-substituted chalcone derivatives were designed, synthesised and evaluated for ...
Zhuo Kong, Demeng Sun, Yanmei Jiang, Yun Hu   +3 more
doaj   +2 more sources

MONOAMINE-OXIDASE INHIBITORS [PDF]

The Lancet, 1964
Publisher Summary This chapter describes the various classes of chemical compounds, which have an inhibitory action on monoamine oxidase (MAO). The chapter discusses the current theories of the function of monoamine oxidase and the possible mechanism by which the MAO inhibitors (MAOI) react with MAO.
A. R. de C. Deacock, E. Harnik
  +9 more sources

Treating hearts and minds: adverse cardiovascular effects of psychiatric medications [PDF]

Therapeutic Advances in Drug Safety
Cardiovascular disease (CVD) is one of the leading causes of death in patients with severe mental illness (SMI), being ~3.3 times higher than in the general population.
Asdaq Shabbir Raja, Stephen J. Leslie, Elizabeth Buist, Gordon F. Rushworth, Ian L. Megson, Neil McNamara   +5 more
doaj   +2 more sources

Moving on With Monoamine Oxidase Inhibitors.

Focus (Am Psychiatr Publ), 2021
Bodkin JA, Dunlop BW.
europepmc   +4 more sources

Cost-effectiveness of dopamine agonists and monoamine oxidase B inhibitors in Parkinson’s disease [PDF]

, 2021
Background: The PD MED study reported small but persistent benefits in patient‐rated mobility scores and quality of life from initiating therapy with levodopa compared with levodopa‐sparing therapies in early Parkinson's disease (PD).
Emma McIntosh, Kent, Seamus, Wheatley, Keith, Rick, Caroline, Caroline Rick, Gray, Alastair, Ives, Natalie, Williams, Adrian, Richard Gray, Gray, Richard, Patel, Smitaa, PD MED Collaborative Group, Seamus Kent, McIntosh, Emma, Keith Wheatley, Smitaa Patel, Carl E. Clarke, Natalie Ives, Alastair Gray, Crispin Jenkinson, Adrian Williams, Clarke, Carl E., Jenkinson, Crispin   +22 more
core   +8 more sources

Molecular docking approach of monoamine oxidase B inhibitors for identifying new potential drugs: Insights into drug-protein interaction discovery [PDF]

Journal of Cell and Molecular Research, 2013
Monoamine oxidase (EC, 1.4.3.4) or amine oxidoreductase catalyzes the oxidative deamination of biogenic amines. Abnormal action of the monoamine oxidase B has been associated with neurological dysfunctions including parkinson´s disorder.
Salimeh Raeisi
doaj   +1 more source

Monoamine oxidase inhibitors and neuroprotective mechanisms

Psychiatry and Clinical Psychopharmacology, 2021
There has been a resurgence of interest in recent years in monoamine oxidase inhibitors, primarily because of the demonstrated neuroprotective and/ or neurorescue properties of several of these drugs in a variety of toxic situations in vivo and in vitro.
Glen Baker, Dmitriy Matveychuk, Erin M. MacKenzie, Serdar Dursun, Darrell D. Mousseau   +4 more
doaj   +1 more source

PART 1: DESIGN, SYNTHESIS AND EVALUATION OF NEW SITE-SPECIFIC MONOAMINE OXIDASE INHIBITORS [PDF]

Bulletin of Pharmaceutical Sciences. Assiut University, 1998
Certain new monoamine oxidase inhibitors (MAOIs) containing a pyridinium moiety as an integral part of their structures (Q) were designed. The quaternaries, their corresponding 1,4-dihydroxypyridine derivatives (CDS) and their parent pyridine compounds ...
N. Bodor, H. Farag, P. Khashaba, N. El-Rabbat, F. Mohamed   +4 more
doaj   +1 more source

STUDY MOLECULES DOCKING OF ALKALOIDS IN KRATOM ON SEROTONIN TRANSPORTER (SERT), NOREPINEPHRINE TRANSPORTER (NET), AND MONOAMINE OXIDASE (MAO)

Jurnal Kimia Riset, 2023
Kratom (Mitragyna speciosa Korth) is a tropical plant originating from Southeast Asia that predominantly contains alkaloid compounds and can potentially maintain levels of monoamine compounds in the body to treat depression.
Dandi Irawan, Bambang Wijianto, Harianto IH   +2 more
doaj   +1 more source

Phenothiazine, anthraquinone and related tricyclic derivatives as inhibitors of d-amino acid oxidase

Results in Chemistry, 2022
A recent study has found that phenothiazine, anthraquinone and related tricyclic derivatives are good potency inhibitors of the monoamine oxidase (MAO) enzymes.
Roslyn Lefin, Anél Petzer, Stephanus J. Cloete, Jacobus P. Petzer   +3 more
doaj   +1 more source