Dopamine dysregulation in a mouse model of paroxysmal nonkinesigenic dyskinesia. [PDF]
, 2012 Paroxysmal nonkinesigenic dyskinesia (PNKD) is an autosomal dominant episodic movement disorder. Patients have episodes that last 1 to 4 hours and are precipitated by alcohol, coffee, and stress.
Edwards, Robert H +10 more
core +2 more sources
HIV-1 infection of microglial cells in a reconstituted humanized mouse model and identification of compounds that selectively reverse HIV latency. [PDF]
, 2017 Most studies of HIV latency focus on the peripheral population of resting memory T cells, but the brain also contains a distinct reservoir of HIV-infected cells in microglia, perivascular macrophages, and astrocytes.
Alvarez-Carbonell, David +4 more
core +1 more source
Prediction of 5-hydroxytryptamine Transporter Inhibitor based on Machine Learning [PDF]
arXiv, 2019 In patients with depression, the use of 5-HT reuptake inhibitors can improve the condition. Topological fingerprints, ECFP4, and molecular descriptors were used. Some SERT and small molecules combined prediction models were established by using 5 machine learning methods. We selected the higher accuracy models(RF, SVM, LR) in five-fold cross-validation
arxiv
Monoamine oxidase A upregulated by chronic intermittent hypoxia activates indoleamine 2,3-dioxygenase and neurodegeneration [PDF]
, 2017 published_or_final_versio
Fung, ML +4 more
core +1 more source
Freeze the BCI until the user is ready: a pilot study of a BCI inhibitor [PDF]
arXiv, 2011 In this paper we introduce the concept of Brain-Computer Interface (BCI) inhibitor, which is meant to standby the BCI until the user is ready, in order to improve the overall performance and usability of the system. BCI inhibitor can be defined as a system that monitors user's state and inhibits BCI interaction until specific requirements (e.g.
arxiv
Monoamine oxidase A expression is vital for embryonic brain development by modulating developmental apoptosis [PDF]
, 2011 Monoamine oxidases (MAO-A, MAO-B) metabolize biogenic amines and have been implicated in neuronal apoptosis. Although apoptosis is an important process in embryo development, the role of MAO isoenzymes has not been investigated in detail.
Alwan +45 more
core +1 more source
Piperidine: A Versatile Heterocyclic Ring for Developing Monoamine Oxidase Inhibitors. [PDF]
ACS Omega, 2023 Jayan J +11 more
europepmc +1 more source
Antidepressant use during pregnancy and the risk of developing gestational hypertension:A retrospective cohort study [PDF]
, 2018 Background: Prior studies reported that exposure to antidepressants during pregnancy may be associated with gestational hypertension. The aim of this study is to assess the association between the use of antidepressants during pregnancy and the risk of ...
Bos, Jens H +5 more
core +2 more sources