Physiological Reports, 2019 Serotonin (5‐HT) accumulates in the heart during myocardial ischemia and induces deleterious effects on the cardiomyocytes through receptor‐dependent and monoamine oxidase‐dependent pathways.
Takashi Sonobe +3 more
doaj +1 more source
Fluorinated tranylcypromine analogues as inhibitors of lysine-specific demethylase 1 (LSD1, KDM1A) [PDF]
, 2017 We report a series of tranylcypromine analogues containing a fluorine in the cyclopropyl ring. A number of compounds with additional m- or p- substitution of the aryl ring were micromolar inhibitors of the LSD1 enzyme.
Al-Jamal, Wafa T. +10 more
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MoleculesMonoamine oxidase B (MAO-B) is a key enzyme in the mitochondrial outer membrane, pivotal for the oxidative deamination of biogenic amines. Its overexpression has been implicated in the pathogenesis of several cancers, including glioblastoma and ...
Iyman Alsaad +6 more
doaj +1 more source
Metabolic Effects of Oral Phenelzine Treatment on High-Sucrose-Drinking Mice [PDF]
, 2018 Phenelzine has been suggested to have an antiobesity effect by inhibiting de novo lipogenesis, which led us to investigate the metabolic effects of oral chronic phenelzine treatment in high-sucrose-drinking mice.
Carpéné, Christian +3 more
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Molecules, 2018 A new series of N-pyridyl-hydrazone derivatives was synthesized by using a simple and efficient method. The final compounds obtained were screened for their inhibitory potency against monoamine oxidase (MAO) A and B. The newly synthesized compounds 2a–2n
Gülhan Turan-Zitouni +4 more
doaj +1 more source
L-deprenyl, A Selective MAO-B Inhibitor [PDF]
, 2011 Monoamine oxidase inhibitors (MAOIs) are now recognized as effective medications in the treatment of major depression (1). However, their clinical use has been limited by the risk of severe hypertensive reactions to oral tyramine challenge. Prevention of
Lam, MD, Raymond W.
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Recreational use, analysis and toxicity of tryptamines [PDF]
, 2015 The definition New psychoactive substances (NPS) refers to emerging drugs whose chemical structures are similar to other psychoactive compounds but not identical, representing a "legal" alternative to internationally controlled drugs.
Mannocchi, Giulio +3 more
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Experimental Pharmacological Research Regarding the Potential Antidepressant Activity Induced by Some Newly Synthesised Dibenzo[a,d]cycloheptene Compounds [PDF]
, 2015 Background. Depression is a relatively frequent encountered mental disorder in the general population, affecting both the quality of the individual life and its ability to perform the social tasks; it is generally accepted that new studies related to ...
Junghină, Adrian +3 more
core +4 more sources
Study on the MAO-A and MAO-B inhibitory properties of a series of new coumarin derivatives for the treatment of Parkinson's disease [PDF]
, 2016 Traballo fin de mestrado (UDC.CIE). Neurociencia.
Aguiar Louzao, Beatriz
core +1 more source
Moving Beyond the Monoamine Hypothesis to Examine the Fundamental Difference in Endocrine Function between Depressed Patients and Normal Patients and Differences in the Physiological Mechanism [PDF]
, 2013 According to the DSM-IV-TR, a depressive disorder is an “illness that involves the body, mood, and thoughts.” It affects the way a person carries out the necessary functions of life, like eating or sleeping, the way a person feels and thinks about ...
Ahmad, Myra
core +2 more sources