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Biologics in Kidney Transplantation: Why and How Should We Personalize Their Dosage? [PDF]
Arrivé C +3 more
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Balancing Act: The Dual Roles of BAFF in Systemic Lupus Erythematosus. [PDF]
Álvarez-Gómez JA +4 more
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The Use of Biological Therapies in the Treatment of Chronic Rhinosinusitis with Nasal Polyps: Current State of Knowledge. [PDF]
Wrona J +6 more
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Anti-IL-6 receptor monoclonal antibody as a new treatment of endometriosis
Immunologic Research, 2020Many pro-inflammatory cytokines especially tumor necrotic factor alpha (TNFα), interleukin (IL)-1β, and IL-6 have crucial role in the pathogenesis of endometriosis. In this study, we investigated the immune-modulatory role of humanized anti-IL-6 receptor monoclonal antibodies in the treatment of endometriosis.
Ahmed A. El-Zayadi +6 more
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Human recombinant dimeric IL-6 binds to its receptor as detected by anti-IL-6 monoclonal antibodies
Molecular Immunology, 1991Three different epitopes of the human IL-6 (IL-6) molecule were recognized by the mAb B-E4 (IgG2b), B-E8 (IgG1) and B-F6 (IgG1). The affinities of these three mAb for IL-6 differ little in several assays but if ranked by affinity they fall into the following order B-E8 greater than B-E4 greater than B-F6.
J, Wijdenes +6 more
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