Results 111 to 120 of about 1,153,626 (336)

Variable major proteins of Borrelia hermsii. Epitope mapping and partial sequence analysis of CNBr peptides. [PDF]

, 1985
The variable major proteins (VMP) of serotypes 7 and 21 of the relapsing fever agent Borrelia hermsii were isolated by detergent extraction and high performance liquid chromatography.
Barbour, AG, Barstad, PA, Coligan, JE, Raum, MG   +3 more
core  

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Application of Monoclonal Antibodies in Veterinary Parasitology [PDF]

Veterinary World, 2011
The discovery of hybridoma technology by Kohler and Milstein in 1975, heralded a new era in antibody research. Mouse hybridomas were the first reliable source of monoclonal antibodies.
Gupta A., Dixit A.K., Dixit Pooja and Mahajan Chetana   +2 more
doaj  

Kinetic Analysis and Epitope Mapping of Monoclonal Antibodies to Salmonella Typhimurium Flagellin Using a Surface Plasmon Resonance Biosensor

Antibodies, 2019
Salmonella Typhimurium is one of the leading causes of foodborne diseases worldwide. Biosensors and immunoassays utilizing monoclonal antibodies are widely used for the detection and subtyping of S. Typhimurium.
Devendra Bhandari, Fur-Chi Chen, Shreya Hamal, Roger C. Bridgman   +3 more
doaj   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

The rapid generation of recombinant functional monoclonal antibodies from individual, antigen-specific bone marrow-derived plasma cells isolated using a novel fluorescence-based method [PDF]

, 2013
Alison Clargo, Ashley R Hudson, Welcome Ndlovu, Rebecca J Wootton, Louise A Cremin, Victoria O’Dowd, Carla R. Nowosad, Dale Starkie, Sophie P. Shaw, Joanne Compson, Dominic P. White, Brendon MacKenzie, James Snowden, Laura E Newnham, Michael Wright, Paul E. Stephens, Meryn Griffiths, Alastair D. G. Lawson, Daniel Lightwood   +18 more
openalex   +1 more source

Third Cranial Nerve Palsy after Monoclonal Antibody Therapy for Lung Cancer: A Case Report [PDF]

, 2022
Paolo Missori, Angela Ambrosone, Leonardo Cristofani, Francesco Fattapposta, Antonio Currà   +4 more
openalex   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Development of Norwalk Virus-Specific Monoclonal Antibodies with Therapeutic Potential for the Treatment of Norwalk Virus Gastroenteritis [PDF]

, 2013
Zhaochun Chen, Stanislav V. Sosnovtsev, Karin Bok, Gabriel I. Parra, Michelle Makiya, Liane Agulto, Kim Y. Green, Robert H. Purcell   +7 more
openalex   +1 more source

Structural and functional characterization of a monoclonal antibody blocking TIGIT

, 2022
Yong‐Sung Kim, Hyemi Nam, Jeewon Lee, Hye-Young Park, Ki Joon Cho, Joong Hyuk Sheen, Eun‐Jung Song, Meesook Oh, Sunggeun Lee, Hyemin Choi, Jae‐Kyung Jung, Munkyung Kim, Byung‐Ha Oh   +12 more
openalex   +1 more source