Results 191 to 200 of about 1,325,739 (304)

The clinical value of multimodal neuroimaging in monoclonal antibody therapy for Alzheimer's disease. [PDF]

Front Neurol
Wang Y, Li H, Zhou J, Zhao S, Yang A, Li Z.   +5 more
europepmc   +1 more source

A Bright Ratiometric Dipyrene Probe for Functional Imaging of Condensate Microenvironments in Living Cells

Advanced Science, EarlyView.
Ratiometric dipyrene imaging resolves monomer (M) and excimer (E) channels and computes pixel‐wise E/M maps within biomolecular condensates, yielding physicochemical fingerprints shaped by coupled polarity‐related solvation and microviscosity. These spatial fingerprints enable quantitative phenotyping of cellular states, exemplified by separation of ...
Koki Matsumoto, Sora Kitai, Yoshio Nishiyama, Shogo Amemori, Kei Makiyama, Dini Kurnia Ikliptikawati, Kentaro Ohira, Yuta Kozuka, Maho Tobita, Shih‐Cheng Chen, Chien‐Hung Yu, Wei‐Min Liu, De‐Chen Lin, Motohiro Mizuno, Kazuma Ogawa, Koichi Ogami, Kenji Takahashi, Hiroshi I. Suzuki, Richard W. Wong, Takahiro Soeta, Masaharu Hazawa   +20 more
wiley   +1 more source

Pharmacokinetics and pharmacodynamics of a long-acting monoclonal antibody against malaria in African adults. [PDF]

J Clin Invest
Tran TM, Hu Z, Kayentao K, Ongoiba A, Jones S, Abla N, Healy SA, Cisse H, Chang BH, Skinner J, Serebryannyy L, Narpala SR, Schlesinger R, Low K, Kazmierski R, Lin B, Dias J, Doumbo S, Doumtabe D, Preston AC, Li S, Peterson ME, Oberai A, Shandling AD, Campo JJ, Murphy SC, Telscher S, Coates EE, Capparelli EV, Dolo A, Traore B, Seder RA, Crompton PD.   +32 more
europepmc   +1 more source

A monoclonal antibody against the extracellular domain of P75 neurotrophin receptor

The aim of this study was to prepare and identify a monoclonal antibody against the extracellular domain of p75 neurotrophin receptor (p75NTR-ECD), which will be used in diagnostics, therapeutics, and as a tool in understanding the role of P75NTR in ...
Li, GC, Xiong, J, Wang, Y, Jiang, Yi, Li, YH, Zhou, Xin-Fu   +5 more
core  

Oral Prebiotic Polysaccharide Hydrogels Sustaining Colon Antibody Release Alleviate Inflammatory Bowel Disease

Advanced Science, EarlyView.
An orally administered prebiotic polysaccharide hydrogel (predaGel) based on inulin and alginate‐dopamine is stable in the stomach, adheres to the intestine, and degrades slowly in the colon. It enables site‐specific delivery of anti‐TNF‐α and anti‐IL‐12/23 antibodies, scavenges reactive oxygen species, and remodels gut microbiota, offering effective ...
Xinyi Dong, Huan He, Li Cao, Fenghua Meng, Zhiyuan Zhong   +4 more
wiley   +1 more source

Safety and Preliminary Efficacy of Dengue Monoclonal Antibody in Adult Patients: A Randomized Clinical Trial.

JAMA Netw Open
Kulkarni PS, Potey AV, Gupta SK, Kodre A, Basu I, Shukla V, Barge V, Munshi R, Mishra AC, Vadakkedath R, Oldach D, Reddy PS, Yeolekar L, Poonawalla CS, Dhere RM, Arankalle VA, Kulkarni R, Gunale B, Dengue-mAb-02 Study Group.   +18 more
europepmc   +1 more source

Differential expression of monoclonal antibody in rat brain following systemic and local administration of AAV. [PDF]

J Pharmacokinet Pharmacodyn
Chowdhury EA, Meno-Tetang G, Liu S, Wu S, Desireddy N, Jerez A, Mahmood L, Rajwade A, Bulusu S, Jamier T, Nucitelli A, Cusdin F, Dobson C, Shah DK.   +13 more
europepmc   +1 more source

EphB1‐Mediated Transient Blood‐Brain Barrier Opening Facilitates a Ferritin‐Based Nanotherapeutic for Alzheimer's Disease

Advanced Science, EarlyView.
We constructed a brain‐targeted AFn‐DPZ nanodrug delivery system and identified EphB1 as its receptor on the blood‐brain barrier (BBB). This system facilitates drug transport across the BBB and thereby ameliorates cognitive impairment in Alzheimer's disease.
Shilin Wen, Jingjing Gao, Zhixian Wang, Qiumin Ma, Xiao‐Ling Xu, Jianer Chen   +5 more
wiley   +1 more source

The Hapten Design, Monoclonal Antibody Preparation, and Immunoassay Development for Rapid Detection of Isofenphos-Methyl. [PDF]

Foods
Lei Y, Chang Y, Shan W, Wang M, She Y, Abd El-Aty AM, Wang J.   +6 more
europepmc   +1 more source

A Novel IDO1/NE Dual Inhibitor, IMM‐H018 Prevents the Primary and Secondary Sepsis and Ameliorates the Kidney Injury Through Inhibiting the Cytokine Storm and Microthrombosis, and Reversing Immunosuppression

Advanced Science, EarlyView.
IMM‐H018, a dual IDO1/NE inhibitor, demonstrates potent therapeutic efficacy in sepsis by simultaneously targeting excessive inflammation and immune dysfunction. It prevents both primary and secondary sepsis through anti‐inflammatory, immune‐restoring, and renoprotective mechanisms, reducing organ damage, improving immune homeostasis, preserving kidney
Yi Zhou, Xiaodi Zhao, Xiaochen Pan, Zhiling Ma, Huaqing Cui, Hui Wen, Peng Wang, Xiufeng Liao, Kejie Qin, Yuchen Wang, Li Sheng, Sen Zhang   +11 more
wiley   +1 more source