Results 201 to 210 of about 759,957 (341)

Negative and positive site-site interactions, and their modulation by pH, insulin analogs, and monoclonal antibodies, are preserved in the purified insulin receptor. [PDF]

, 1988
C C Wang, Ira D. Goldfine, Yoko Fujita‐Yamaguchi, H.‐G. Gattner, D. Brandenburg, Pierre De Meyts   +5 more
openalex   +1 more source

Affinity‐Based Isolation and One‐Pot Analysis of Extracellular Vesicles from Biofluids Using Phase Separated Zwitterionic Coacervates

Advanced Science, EarlyView.
This study presents a novel method for affinity‐based isolation and analysis of extracellular vesicles from biofluids using phase‐separated zwitterionic coacervates functionalized with a membrane‐sensing peptide. This technology minimizes nonspecific binding, enabling high‐yield isolation and direct one‐pot biomarker profiling.
Francesca Torrini, Roberto Frigerio, Jonathan Garlipp, Philippe Lenzen, Karl Normak, Carolina Paganini, Marina Cretich, Alessandro Gori, Paolo Arosio   +8 more
wiley   +1 more source

Advancing Monoclonal Antibody Manufacturing: Process Optimization, Cost Reduction Strategies, and Emerging Technologies. [PDF]

Biologics
Ranbhor R.
europepmc   +1 more source

Antigenic analysis of Serratia marcescens fimbriae with monoclonal antibodies [PDF]

, 1987
Seiya Jingushi, Masao Mitsuyama, Toshimitsu Moriya, Kazunobu Amako   +3 more
openalex   +1 more source

YC‐4‐3, a Novel Glycogen Synthase Kinase 3β Inhibitor, Alleviates the Endoplasmic Reticulum Stress of Macrophages in Primary Immune Thrombocytopenia

Advanced Science, EarlyView.
A patented GSK‐3β inhibitor (GSK‐3βi), new benzothiazepinone compounds (BTZs), YC‐4‐3, can modulate the inflammatory status of macrophages in primary immune thrombocytopenia (ITP), and improve the thrombocytopenia in murine ITP models by directly interacting with endoplasmic reticulum (ER) stress response.
Pengcheng Xu, Lili Ji, Yanxia Zhan, Yang Ou, Xia Shao, Xibing Zhuang, Fanli Hua, Feng Li, Hao Chen, Yong Chu, Yunfeng Cheng   +10 more
wiley   +1 more source

Efficacy of MEDI0618, a pH-dependent monoclonal antibody targeting PAR2, in preclinical models of migraine. [PDF]

Brain
Kopruszinski CM, Linley JE, Thornton P, Walker AS, Newton P, Podichetty S, Ruparel RH, Moreira de Souza LH, Navratilova E, Meno-Tetang G, Gurrell I, Dodick DW, Dobson C, Chessell T, Porreca F, Chessell I.   +15 more
europepmc   +1 more source

A rapid method for the selective identification ofAutographa californicanuclear polyhedrosis virus using a monoclonal antibody [PDF]

, 1982
Werner L. Naser, H.G. Miltenburger
openalex   +1 more source

The Super Enhancer‐Driven Long Noncoding RNA PRKCQ‐AS1 Promotes Neuroblastoma Tumorigenesis by Interacting With MSI2 Protein and Is Targetable by Small Molecule Compounds

Advanced Science, EarlyView.
PRKCQ‐AS1 is overexpressed due to transcriptional super‐enhancers. PRKCQ‐AS1 RNA forms a complex with MSI2 protein to induce BMX mRNA stabilization and overexpression, ERK protein phosphorylation and neuroblastoma cell proliferation. Compound NSC617570 blocks PRKCQ‐AS1 binding to MSI2, leading to BMX mRNA disassociation from MSI2 protein, BMX reduction,
Sujanna Mondal, Pei Y. Liu, Janith Seneviratne, Antoine De Weck, Pooja Venkat, Chelsea Mayoh, Jing Wu, Jesper Maag, Jingwei Chen, Matthew Wong, Nenad Bartonicek, Poh Khoo, Lei Jin, Louise E. Ludlow, David S. Ziegler, Toby Trahair, Pieter Mestdagh, Belamy B. Cheung, Jinyan Li, Marcel E. Dinger, Ian Street, Xu D. Zhang, Glenn M. Marshall, Tao Liu   +23 more
wiley   +1 more source

Advancing Allogeneic NK Cell Immunotherapy through Microfluidic Gene Delivery

Advanced Science, EarlyView.
The Y‐Hydroporator is a microfluidic gene delivery platform designed for allogeneic NK cell‐based immunotherapies. It achieves highly efficient gene delivery while preserving high cell viability and functionality. By producing engineered NK cells with enhanced cytotoxicity, the platform addresses critical limitations of autologous cell therapy ...
Hyelee Kim, Mujin Lee, Bohwa Han, Jinho Kim, Duck Cho, Junsang Doh, Aram J. Chung   +6 more
wiley   +1 more source

Development of the TSR-based computational method to investigate spike and monoclonal antibody interactions. [PDF]

Front Chem
Milon TI, Sarkar T, Chen Y, Grider JM, Chen F, Ji JY, Jois SD, Kousoulas KG, Raghavan V, Xu W.   +9 more
europepmc   +1 more source