Results 211 to 220 of about 1,226,593 (337)

Strategies to Improve the Lipophilicity of Hydrophilic Macromolecular Drugs

Advanced Healthcare Materials, EarlyView.
Hydrophilic macromolecular drugs can be successfully lipidized by covalent attachment of lipids, by hydrophobic ion pairing with negatively or positively charged surfactants, and by dry or wet reverse micelle formation. Lipophilicity enhancement of hydrophilic macromolecules has several benefits including stability and bioavailability improvement ...
Sera Lindner, Stefan Keim, Soheil Haddadzadegan, Odile Fernandez Romero, Katrin Zöller, Gabriel Stern, Ilaria Cesi, Krum Kafedjiiski, Andreas Bernkop‐Schnürch   +8 more
wiley   +1 more source

Pretargeted Immuno-PET Enables Monoclonal Antibody Imaging Beyond the Blood-Brain Barrier. [PDF]

Mol Pharm
Gustavsson T, Kustermann T, Hvass L, Wuensche TE, Clausen AS, Stotz S, Shalgunov V, Lopes van den Broek S, Knudsen GM, Aldana B, Ferri E, Cannazza G, Niewoehner J, Gobbi L, Honer M, Battisti UM, Kjaer A, Herth MM.   +17 more
europepmc   +1 more source

Therapeutic administration of a recombinant human monoclonal antibody reduces the severity of chikungunya virus disease in rhesus macaques [PDF]

, 2017
Diamond, Michael S, et al,, Fox, Julie M, Sukulpovi-Petty, Soila   +3 more
core   +1 more source

Neonatal Foreskin Substrate Has Limitations for the Immunofluorescent Screening of Monoclonal Antibodies

, 2021
David T. Woodley, Therese Ernst, Melinda J. Reese, Nancy Ogden, W. Ray Gammon, Robert A. Briggaman, Ronald J. Falk   +6 more
openalex   +1 more source

Fibrillar Bundles as Fibrous Filler Materials for Attaining Cell Anisotropy in Bioprinting

Advanced Healthcare Materials, EarlyView.
Fibrillar bundles are introduced as a bioprintable additive that enables robust and scalable cellular alignment within 3D constructs through flow‐induced orientation during extrusion. These fibers support strong cell adhesion and polarization across various cell types and significantly enhance myotube alignment in Gelatine‐Methacryloyl (GelMA ...
Sven Heilig, Zan Lamberger, Lys Sprenger, Vivien Priebe, Camilla Mussoni, Denitsa Docheva, Kristina Andelovic, Jürgen Groll, Sahar Salehi, Gregor Lang, Matthias Ryma   +10 more
wiley   +1 more source

A monoclonal antibody selectively recognizing PfEMP1 proteins associated with cerebral malaria. [PDF]

Sci Rep
Dalgaard N, Olsen RW, Adams Y, Mendez BL, Rudbaek JJ, Bisholm SAG, Mousiliou A, Walker MR, Hviid L, Tahar R, Ndam NT, Barfod L, Jensen AR.   +12 more
europepmc   +1 more source

T330M Substitution in the Sodium-Dependent Phosphate Transporter NaPi2b Abolishes the Efficacy of Monoclonal Antibodies Against MX35 Epitope [PDF]

L.F. Bulatova, V. Skripova, Aisylu R. Sagdeeva, Ramilia Vlasenkova, Tatiana A. Bugaenko, Р Р Галимова, А. И. Хасанова, Yuliya V. Filina, Ramziya Kiyamova   +8 more
openalex   +1 more source

Supplementary Figure Legends 1-3 from Results of a Phase 1 Study of AME-133v (LY2469298), an Fc-Engineered Humanized Monoclonal Anti-CD20 Antibody, in FcγRIIIa-Genotyped Patients with Previously Treated Follicular Lymphoma

, 2023
Andres Forero‐Torres, Sven de Vos, Brad L. Pohlman, Maksim Pashkevich, Damien M. Cronier, Nam H. Dang, Susan P. Carpenter, Barrett W. Allan, J.G. Nelson, Christopher A. Slapak, Mitchell R. Smith, Brian K. Link, James E. Wooldridge, Kristen N. Ganjoo   +13 more
openalex   +1 more source

Advances in Bioprinting to Model Immune‐Mediated Skin Diseases

Advanced Healthcare Materials, EarlyView.
This review explores how 3D bioprinting drives innovation in developing in vitro skin models that mimic immune‐mediated diseases. It highlights current technologies, key applications in studying skin pathologies, and emerging challenges. The review points toward future opportunities for improving disease modeling and advancing therapeutic and cosmetic ...
Andrea Ulloa‐Fernández, Marica Markovic, Julia Fernández‐Pérez, Georg Stary, Aleksandr Ovsianikov   +4 more
wiley   +1 more source

Safety and tolerability of astegolimab, an anti-ST2 monoclonal antibody: a narrative review. [PDF]

Respir Res
Kelsen SG, Maurer M, Waters M, Dash A, Fong A, Mohan D, Theess W, Yang X, Alvaro G, Brightling CE.   +9 more
europepmc   +1 more source