Results 221 to 230 of about 771,983 (316)

A Scoping Review of Preclinical Research on Monoclonal Antibody Development for Prophylaxis and Treatment of West Nile Virus Infections. [PDF]

Viruses
Calvert AE, Miazgowicz KL, Atkinson B, Long AH, Thrasher E, Brault AC, Nett RJ.   +6 more
europepmc   +1 more source

NOX2 Contributes to High‐Frequency Outer Hair Cell Vulnerability in the Cochlea

Advanced Science, EarlyView.
This study first identifies NOX2 as a differentially expressed gene related to oxidative damage in the apical and basal turns through single‐cell RNA sequencing. NOX2 gene knockout mitigates OHCs damage caused by neomycin and noise and enhances Nrf2 expression and nuclear translocation.
Meihao Qi, Zejun Gao, Yang Qiu, Renfeng Wang, Keyong Tian, Bo Yue, Xinyu Zhang, Peng Zhang, Ziqi Wu, Qingwen Zhu, Zhenzhen Liu, Zhuoyao Ma, Xueying Zhou, Yu Han, Jun Chen, Jianhua Qiu, DingJun Zha   +16 more
wiley   +1 more source

Recommended nomenclature convention for the NISTCHO cell line and its product monoclonal antibody, cNISTmAb. [PDF]

MAbs
Cleveland MH, Karageorgos IL, Marino JP, Tarlov MJ, Yandrofski KS, Zangmeister RA, Kelman Z.   +6 more
europepmc   +1 more source

AAVR Expression is Essential for AAV Vector Transduction in Sensory Hair Cells

Advanced Science, EarlyView.
Decreased sensitivity to AAV vector transduction in the outer hair cells (OHCs) of adult mice is primarily attributed to reduction of AAVR (Kiaa0319l; Au040320). Knockout of AAVR reduces AAV vector transduction efficiency in both inner hair cells (IHCs) and OHCs in neonatal mice.
Fan Wu, Guisheng Chen, Rui Hu, Peiwen Liu, Jintao Lou, Wenji Zhao, Zuhong He, Suhua Sha, Yiqing Zheng   +8 more
wiley   +1 more source

Editorial: Antiviral monoclonal antibody therapies. [PDF]

Front Cell Infect Microbiol
Florez C, Haslwanter D, Jangra RK.
europepmc   +1 more source

Topoisomerase I Inhibition in ETV4‐overexpressed Non‐Small Cell Lung Cancer Promotes Replication and Transcription Mediated R‐Loop Accumulation and DNA Damage

Advanced Science, EarlyView.
The oncogenic ETS factor ETV4 exerts a pleiotropic control over DNA replication both in a transcription‐dependent and ‐independent fashion in NSCLC cells. High‐ETV4 expression leads to R‐loop formation and DNA damage in response to TOP1 inhibition.
Jiaxi Zhang, Yan Wang, Shanhu Cao, Shelly M. Xie, Bei Liu, Yimeng Li, Yuqi Hou, Xue Meng, Mingzhu Ruan, Di Bu, Jia Kang, Ruxin Li, Lei Lou, Juan Wang, Lingxiao Xing   +14 more
wiley   +1 more source

Simple recombinant monoclonal antibody production from <i>Escherichia coli</i>. [PDF]

Open Biol
Baker K, Eastwood TA, Garcia E, Lennon C, Mulvihill DP.   +4 more
europepmc   +1 more source

AN ANTI-HUMAN-T-CELL MONOCLONAL ANTIBODY WITH SPECIFICITY FOR A NOVEL DETERMINANT

, 1988
Ralph Quinones, Joan K. Lunney, Ronald E. Gress   +2 more
openalex   +1 more source

Tryptophan Metabolite Indole‐3‐Aldehyde Induces AhR and c‐MYC Degradation to Promote Tumor Immunogenicity

Advanced Science, EarlyView.
Tryptophan metabolite Indole‐3‐aldehyde (I3A) downregulates cytosolic AhR and p‐ERK/c‐MYC proteins, together enhancing STAT3 phosphorylation and tumor immunogenicity. Overexpression of the Trp metabolic enzyme interleukin‐4‐induced gene‐1 (IL4I1) in tumor cells increases intracellular levels of I3A and enhances tumor immunogenicity.
Lei Cui, Zining Wang, Zixuan Guo, Hongxia Zhang, Yongxiang Liu, Huanling Zhang, Huan Jin, Feifei Xu, Xiaojuan Wang, Chunyuan Xie, Hui Guo, Tiantian Wang, Yanxun Lin, Qi Zhao, Penghui Zhou, Jing Tan, Jin‐Xin Bei, Peng Huang, Jinyun Liu, Xiaojun Xia   +19 more
wiley   +1 more source

Structure and function of an unusual R452-dependent monoclonal antibody against SARS-CoV-2. [PDF]

J Virol
Zhou B, Gui Q, Liu C, Guo H, Wang H, Cheng L, Fan Q, Ge X, Zhang Z, Ju B.   +9 more
europepmc   +1 more source