Results 31 to 40 of about 1,385,819 (261)

Arginine mutation alters binding of a human monoclonal antibody to antigens linked to systemic lupus erythematosus and the antiphospholipid syndrome [PDF]

, 2007
Objective: Previous studies have shown the importance of somatic mutations and arginine residues in the complementarity-determining regions (CDRs) of pathogenic anti-double-stranded DNA (anti-dsDNA) antibodies in human and murine lupus, and in studies of
Yiannis Ioannou, Lambrianides, A., Anisur Rahman, Isenberg, D.A., Lesley Mason, Giles, I., Ioannou, Y., Latchman, D.S., Mason, L., Jessica J. Manson, Ian Giles, Manson, J.J., David A. Isenberg, David S. Latchman, Rahman, A., Anastasia Lambrianides   +15 more
core   +1 more source

Establishment and Functional Characterization of Murine Monoclonal Antibodies Recognizing Neuritin

Antibodies, 2023
Neuritin represents a neurotrophic factor that is not only important in neuronal development and plasticity but also impacts endothelial angiogenesis, cell migration, tumor growth and the production of antibodies by B cells.
Georgia Papadogianni, Inga Ravens, Ahmed Hassan, Andrew Flatley, Regina Feederle, Günter Bernhardt, Hristo Georgiev   +6 more
doaj   +1 more source

Characterization of monoclonal and polyclonal antibodies to bovine enteric coronavirus: Establishment of an efficient ELISA for antigen detection in feces [PDF]

, 1989
Monoclonal antibodies to bovine enteric coronavirus (BEC) were produced. Additionally, polyclonal antibodies were made in rabbits and guinea pigs and extracted from the yolk of immunized hens.
Eichhorn, Werner, Czerny, C. P.
core   +1 more source

Save the microbes to save the planet. A call to action of the International Union of the Microbiological Societies (IUMS)

One Health Outlook, 2023
Our planet is populated by at least a trillion species of microorganisms. Every life form is sustained by them and they make the planet habitable. Only a minority of them, about 1400 species, cause infectious diseases that are responsible for human ...
Rino Rappuoli, Paul Young, Eliora Ron, Simone Pecetta, Mariagrazia Pizza   +4 more
doaj   +1 more source

Production of two SARS-CoV-2 neutralizing antibodies with different potencies in Nicotiana benthamiana

Frontiers in Plant Science, 2022
Monoclonal antibodies are considered to be highly effective therapeutic tools for the treatment of mild to moderate COVID-19 patients. In the present work, we describe the production of two SARS-CoV-2 human IgG1 monoclonal antibodies recognizing the ...
Rachele Frigerio, Carla Marusic, Maria Elena Villani, Chiara Lico, Cristina Capodicasa, Emanuele Andreano, Ida Paciello, Rino Rappuoli, Rino Rappuoli, Anna Maria Salzano, Andrea Scaloni, Selene Baschieri, Marcello Donini   +12 more
doaj   +1 more source

The production of polyclonal, monoclonal and genetically-derived scFv antibody fragments for the detection of the ß-lactam antibiotic, cephalexin, in milk [PDF]

, 2006
This thesis describes the production of antibodies for the detection of cephalexin and their application in ELISA and Biacore ‘real-time’ surface plasmon resonance (SPR)-based biosensor assays.
Darmanin Sheehan, Alfredo
core   +2 more sources

Lentil lectin derived from Lens culinaris exhibit broad antiviral activities against SARS-CoV-2 variants

Emerging Microbes and Infections, 2021
The spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mutated continuously and newly emerging variants escape from antibody-mediated neutralization raised great concern.
Wenbo Wang, Qianqian Li, Jiajing Wu, Yu Hu, Gang Wu, Chuanfei Yu, Kangwei Xu, Xumei Liu, Qihui Wang, Weijin Huang, Lan Wang, Youchun Wang   +11 more
doaj   +1 more source

Classical Complement Pathway Inhibition in a Pediatric Patient With Refractory Immune Thrombocytopenia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric refractory immune thrombocytopenia (rITP) is generally characterized by persistent thrombocytopenia and failure to achieve a sustained response to multiple standard therapies. We report a 4‐year‐old female with congenital tufting enteropathy, post‐intestinal transplant patient on immunosuppressants, who developed severe rITP ...
Sarah Hsieh, Susmita Sarangi, Caileigh Pudela, Catherine M. Broome, Tara K. Suntum   +4 more
wiley   +1 more source

Deep-learning image analysis for high-throughput screening of opsono-phagocytosis-promoting monoclonal antibodies against Neisseria gonorrhoeae

Scientific Reports
Antimicrobial resistance (AMR) is nowadays a global health concern as bacterial pathogens are increasingly developing resistance to antibiotics. Monoclonal antibodies (mAbs) represent a powerful tool for addressing AMR thanks to their high specificity ...
Fabiola Vacca, Dario Cardamone, Emanuele Andreano, Duccio Medini, Rino Rappuoli, Claudia Sala   +5 more
doaj   +1 more source

Immune response to SARS-CoV-2 Omicron variant in patients and vaccinees following homologous and heterologous vaccinations

Communications Biology, 2022
Antibodies elicited by a triple homologous or heterologous vaccination regimen or following natural SARS-CoV-2 infection combined with a two-dose vaccine course, result in highest neutralization capacity against the Omicron variant BA.1.
Claudia Maria Trombetta, Giulia Piccini, Giulio Pierleoni, Margherita Leonardi, Francesca Dapporto, Serena Marchi, Emanuele Andreano, Ida Paciello, Linda Benincasa, Piero Lovreglio, Nicola Buonvino, Nicola Decaro, Angela Stufano, Eleonora Lorusso, Emilio Bombardieri, Antonella Ruello, Simonetta Viviani, Rino Rappuoli, Eleonora Molesti, Alessandro Manenti, Emanuele Montomoli   +20 more
doaj   +1 more source