Results 41 to 50 of about 1,325,739 (304)

Lentil lectin derived from Lens culinaris exhibit broad antiviral activities against SARS-CoV-2 variants

Emerging Microbes and Infections, 2021
The spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mutated continuously and newly emerging variants escape from antibody-mediated neutralization raised great concern.
Wenbo Wang, Qianqian Li, Jiajing Wu, Yu Hu, Gang Wu, Chuanfei Yu, Kangwei Xu, Xumei Liu, Qihui Wang, Weijin Huang, Lan Wang, Youchun Wang   +11 more
doaj   +1 more source

Immune response to SARS-CoV-2 Omicron variant in patients and vaccinees following homologous and heterologous vaccinations

Communications Biology, 2022
Antibodies elicited by a triple homologous or heterologous vaccination regimen or following natural SARS-CoV-2 infection combined with a two-dose vaccine course, result in highest neutralization capacity against the Omicron variant BA.1.
Claudia Maria Trombetta, Giulia Piccini, Giulio Pierleoni, Margherita Leonardi, Francesca Dapporto, Serena Marchi, Emanuele Andreano, Ida Paciello, Linda Benincasa, Piero Lovreglio, Nicola Buonvino, Nicola Decaro, Angela Stufano, Eleonora Lorusso, Emilio Bombardieri, Antonella Ruello, Simonetta Viviani, Rino Rappuoli, Eleonora Molesti, Alessandro Manenti, Emanuele Montomoli   +20 more
doaj   +1 more source

A Systematic Review of Circulating Tumor Cells in Renal Cell Carcinoma

Translational Research in Urology, 2021
Introduction Renal cell carcinoma (RCC) is one of the most usual kidney’s tumors. The improvement of non-invasive biomarkers will make it feasible to investigate whose have high risk of recurrence after radical or partial nephrectomy and will expand the
Seyed Mohammad Kazem Aghamir, Mohadeseh Nasir Shirazi, Fatemeh Khatami   +2 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Deep-learning image analysis for high-throughput screening of opsono-phagocytosis-promoting monoclonal antibodies against Neisseria gonorrhoeae

Scientific Reports
Antimicrobial resistance (AMR) is nowadays a global health concern as bacterial pathogens are increasingly developing resistance to antibiotics. Monoclonal antibodies (mAbs) represent a powerful tool for addressing AMR thanks to their high specificity ...
Fabiola Vacca, Dario Cardamone, Emanuele Andreano, Duccio Medini, Rino Rappuoli, Claudia Sala   +5 more
doaj   +1 more source

Safety and serum distribution of anti-SARS-CoV-2 monoclonal antibody MAD0004J08 after intramuscular injection

Nature Communications, 2022
Monoclonal antibodies (mAbs) are a potential therapeutic option for treatment of COVID-19. Here, the authors report safety and pharmacokinetics of an intramuscularly injected mAb (MAD0004J08) during the first 30 days of a phase 1 clinical study.
Simone Lanini, Stefano Milleri, Emanuele Andreano, Sarah Nosari, Ida Paciello, Giulia Piccini, Alessandra Gentili, Adhuna Phogat, Inesa Hyseni, Margherita Leonardi, Alessandro Torelli, Emanuele Montomoli, Andrea Paolini, Andrea Frosini, Andrea Antinori, Emanuele Nicastri, Enrico Girardi, Maria Maddalena Plazzi, Giuseppe Ippolito, Francesco Vaia, Giovanni Della Cioppa, Rino Rappuoli   +21 more
doaj   +1 more source

A study of antibody secretion from hybridoma cells [PDF]

, 1988
The secretion of monoclonal antibody in both batch and continuous cultures was studied. It was found that when hybridoma cells were continuously cultivated in a simple lab scale fermenter, they secreted less antibody than cells grown in stationary ...
Holland, P.N.
core  

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Oral vaccines for rainbow trout: Promising solutions to combat bacterial and viral pathogens in aquaculture

Comparative Immunology Reports
Oral vaccination represents a transformative approach for disease prevention in rainbow trout aquaculture, offering the promise of mass immunization with minimal handling stress and improved welfare.
Mahboobeh Nazari, Mahmood Jeddi-Tehrani
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source