Results 21 to 30 of about 13,966 (231)

It is worth the weight: obesity and the transition from monoclonal gammopathy of undetermined significance to multiple myeloma

Blood Advances, 2023
The overweight/obesity epidemic is a serious public health concern that affects >40% of adults globally and increases the risk of numerous chronic diseases, such as type 2 diabetes, heart disease, and various cancers.
R. Choa, Cristina Panaroni, Roma Bhatia, N. Raje   +3 more
semanticscholar   +1 more source

The clinical relevance and management of monoclonal gammopathy of undetermined significance and related disorders: recommendations from the European Myeloma Network

Haematologica, 2014
Monoclonal gammopathy of undetermined significance is one of the most common pre-malignant disorders. IgG and IgA monoclonal gammopathy of undetermined significance are precursor conditions of multiple myeloma; light-chain monoclonal gammopathy of ...
Niels W.C.J. van de Donk, Antonio Palumbo, Hans Erik Johnsen, Monika Engelhardt, Francesca Gay, Henrik Gregersen, Roman Hajek, Martina Kleber, Heinz Ludwig, Gareth Morgan, Pellegrino Musto, Torben Plesner, Orhan Sezer, Evangelos Terpos, Anders Waage, Sonja Zweegman, Hermann Einsele, Pieter Sonneveld, Henk M. Lokhorst   +18 more
doaj   +1 more source

Iceland screens, treats, or prevents multiple myeloma (iStopMM): a population-based screening study for monoclonal gammopathy of undetermined significance and randomized controlled trial of follow-up strategies

Blood Cancer Journal, 2021
Monoclonal gammopathy of undetermined significance (MGUS) precedes multiple myeloma (MM). Population-based screening for MGUS could identify candidates for early treatment in MM.
S. Rögnvaldsson, T. Love, Sigrún Thorsteinsdóttir, E. Reed, J. Oskarsson, Íris Pétursdóttir, G. Á. Sigurðardóttir, Brynjar Viðarsson, P. Önundarson, B. Agnarsson, Margrét Sigurðardóttir, Ingunn Þorsteinsdóttir, I. Olafsson, Á. R. Þórðardóttir, Elías Eyþórsson, Á. Jónsson, A. S. Björnsson, G. T. Gunnarsson, R. Palsson, Ó. S. Indriðason, G. Gíslason, A. Olafsson, Gudlaug Katrin Hakonardottir, M. Brinkhuis, Sara Lovísa Halldórsdóttir, T. L. Ásgeirsdóttir, H. Steingrímsdóttir, R. Danielsen, Inga Dröfn Wessman, P. Kampanis, Malin Hulcrantz, B. Durie, S. Harding, O. Landgren, S. Kristinsson   +34 more
semanticscholar   +1 more source

Monoclonal gammopathy of undetermined significance and risk of infections: a population-based study

Haematologica, 2012
No comprehensive evaluation has been made to assess the risk of viral and bacterial infections among patients with monoclonal gammopathy of undetermined significance.
Sigurdur Y. Kristinsson, Min Tang, Ruth M Pfeiffer, Magnus Björkholm, Lynn R. Goldin, Cecilie Blimark, Ulf-Henrik Mellqvist, Anders Wahlin, Ingemar Turesson, Ola Landgren   +9 more
doaj   +1 more source

Monoclonal Gammopathy of Renal Significance—A Rare Renal Presentation: A Review of Cases Reported

Journal of Investigative Medicine High Impact Case Reports, 2020
Monoclonal gammopathy of undetermined significance is a precursor to multiple myeloma characterized by monoclonal gammopathy without evidence of end organ damage.
Asim Kichloo MD, Najma Nawaz MD, Jagmeet Singh MD, Michael Aljadah MD, Michael Stanley Albosta MD, Ravinder Bhanot MD   +5 more
doaj   +1 more source

Secondary monoclonal gammopathy of undetermined significance after allogeneic stem cell transplantation in multiple myeloma

Haematologica, 2014
In the course of multiple myeloma, patients may develop a M-protein band different from the original: secondary monoclonal gammopathy of undetermined significance.
Marian F. Schmitz, Henny G. Otten, Laurens E. Franssen, Suzanne van Dorp, Theo Strooisma, Henk M. Lokhorst, Niels W.C.J. van de Donk   +6 more
doaj   +1 more source

Investigation and management of the monoclonal gammopathy of undetermined significance

British Journal of Haematology, 2023
This Good Practice Paper provides recommendations for the diagnosis, risk stratification and management of the monoclonal gammopathy of undetermined significance (MGUS). It describes the recently recognised entity of the monoclonal gammopathy of clinical
S. Stern, Satarupa Chaudhuri, M. Drayson, Sarah Henshaw, Kamaraj Karunanithi, F. Willis   +5 more
semanticscholar   +1 more source

Immunoglobulin M Monoclonal Gammopathies of Clinical Significance

Frontiers in Oncology, 2022
Immunoglobulin M monoclonal gammopathy of undetermined significance (MGUS) comprises 15-20% of all cases of MGUS. IgM MGUS is distinct from other forms of MGUS in that the typical primary progression events include Waldenstrom macroglobulinaemia and ...
Louis-Pierre Girard, Cinnie Yentia Soekojo, Melissa Ooi, Wee Joo Chng, Wee Joo Chng, Wee Joo Chng, Sanjay de Mel   +6 more
doaj   +1 more source

Prognostic impact of MYD88 and CXCR4 mutations assessed by droplet digital polymerase chain reaction in IgM monoclonal gammopathy of undetermined significance and smouldering Waldenström macroglobulinaemia

British Journal of Haematology, 2022
Waldenström macroglobulinaemia (WM) is characterized by recurrent somatic mutations in MYD88 and CXCR4 genes. However, limitations arise when analysing these mutations in IgM monoclonal gammopathy of undetermined significance (MGUS) or smouldering WM ...
David F. Moreno, M. López-Guerra, Sara Paz, Aina Oliver-Cáldes, M. Mena, J. Correa, Anthony M. Battram, M. Osuna, A. Rivas-Delgado, L. Rodríguez-Lobato, Oriol Cardus, N. Tovar, M. Cibeira, Raquel Jiménez-Segura, J. Bladé, L. Rosiñol, D. Colomer, C. Fernández de Larrea   +17 more
semanticscholar   +1 more source

Transcriptome analysis reveals molecular profiles associated with evolving steps of monoclonal gammopathies

Haematologica, 2014
A multistep model has been proposed of disease progression starting in monoclonal gammopathy of undetermined significance continuing through multiple myeloma, sometimes with an intermediate entity called smoldering myeloma, and ending in extramedullary ...
Lucía López-Corral, Luis Antonio Corchete, María Eugenia Sarasquete, María Victoria Mateos, Ramón García-Sanz, Encarna Fermiñán, Juan-José Lahuerta, Joan Bladé, Albert Oriol, Ana Isabel Teruel, María Luz Martino, José Hernández, Jesús María Hernández-Rivas, Francisco Javier Burguillo, Jesús F. San Miguel, Norma C. Gutiérrez   +15 more
doaj   +1 more source