Results 61 to 70 of about 13,966 (231)

Epidemiology of Monoclonal Gammopathies in Sub‐Saharan Africa: A Systematic Review and Meta‐Analysis of MGUS and Multiple Myeloma

Tropical Medicine &International Health, EarlyView.
ABSTRACT Background Monoclonal gammopathy of undetermined significance (MGUS) and multiple myeloma (MM) are reported to occur more frequently in Black populations, particularly African Americans. However, despite Sub‐Saharan Africa (SSA) being home to the largest Black population globally, epidemiological data on MGUS and MM in the region remain scarce.
Iyanuloluwa S. Ojo, Olurotimi John Badero, Toluwalope Olawale Oluwalana, Nicholas Aderinto, Faridat Ibidun, Onur Oral, Emmanuel Oyesiji, Evelyn Faith Ogungbemi   +7 more
wiley   +1 more source

Pattern of somatic mutations in patients with Waldenström macroglobulinemia or IgM monoclonal gammopathy of undetermined significance

Haematologica, 2017
We analyzed MYD88 and CXCR4 mutation status of 260 patients with Waldenström macroglobulinemia or IgM monoclonal gammopathy of undetermined significance using allele-specific real time quantitative polymerase chain reaction and Sanger sequencing ...
Marzia Varettoni, Silvia Zibellini, Irene Defrancesco, Virginia Valeria Ferretti, Ettore Rizzo, Luca Malcovati, Anna Gallì, Matteo Giovanni Della Porta, Emanuela Boveri, Luca Arcaini, Chiara Candido, Marco Paulli, Mario Cazzola   +12 more
doaj   +1 more source

Establishing Monoclonal Gammopathy of Undetermined Significance as an Independent Pre-Disease State of Multiple Myeloma Using Raman Spectroscopy, Dynamical Network Biomarker Theory, and Energy Landscape Analysis

International Journal of Molecular Sciences
Multiple myeloma (MM) is a cancer of plasma cells. Normal (NL) cells are considered to pass through a precancerous state, such as monoclonal gammopathy of undetermined significance (MGUS), before transitioning to MM.
Shota Yonezawa, Takayuki Haruki, Keiichi Koizumi, Akinori Taketani, Yusuke Oshima, Makito Oku, A. Wada, Tsutomu Sato, N. Masuda, Jun Tahara, Noritaka Fujisawa, Shota Koshiyama, Makoto Kadowaki, Isao Kitajima, S. Saito   +14 more
semanticscholar   +1 more source

Monoclonal Gammopathy of Undetermined Significance (MGUS)—Not So Asymptomatic after All

Cancers, 2020
Monoclonal Gammopathy of Undetermined Significance (MGUS) is considered to be a benign precursor condition that may progress to a lymphoproliferative disease or multiple myeloma. Most patients do not progress to an overt condition, but nevertheless, MGUS
O. Lomas, Tarek H. Mouhieddine, S. Tahri, I. Ghobrial   +3 more
semanticscholar   +1 more source

Prognostic Impact of the Hevylite Assay in Patients With IgG or IgA Multiple Myeloma Treated Within the GMMG‐MM5 Trial

European Journal of Haematology, Volume 116, Issue 3, Page 226-234, March 2026.
ABSTRACT Response assessment during treatment of multiple myeloma (MM) typically relies on immunofixation and serum electrophoresis. However, low levels of IgG and especially IgA paraprotein are difficult to quantify reliably. The Hevylite Assay quantifies the kappa and lambda fractions of IgG and IgA separately and is useful to determine response to ...
Tim Richardson, Elias Mai, Ekaterina Menis, Axel Benner, Diana Tichy, Kaya Miah, Mathias Hänel, Britta Besemer, Amelie Boquoi, Igor Wolfgang Blau, Christian S. Michel, Hans Walter Lindemann, Snjezana Janjetovic, Peter Brossart, Helga Bernhard, Peter Reimer, Hans Salwender, Dirk Hose, Anja Seckinger, Marc Raab, Hartmut Goldschmidt, Christof Scheid, For the German‐Speaking Myeloma Multicenter Group (GMMG) HD5 Investigators, Koordinierungszentrum für Klinische Studien, KKS) Heidelberg, Facharztpraxis Hämatologie und Onkologie, Praxisnetzwerk Hämatologie/Internistische Onkologie, Facharztpraxis Onkologie, Caritas Krankenhaus Bad Mergentheim, MVZ Baden‐Baden, Charité Universitätsmedizin Berlin, Charité Universitätsmedizin Berlin, HELIOS Klinikum Berlin‐Buch, Medizinisches Versorgungszentrum, Facharztpraxis Onkologie, Onkologie Seestrasse, Klinikum Bielefeld Mitte, Facharztpraxis Onkologie, Universitätsklinikum Bonn, Johanniter Krankenhaus Bonn, Onkologie Rheinsieg, Städt. Klinikum Braunschweig, Onkologische Schwerpunktpraxis, Onkologische Praxis im Krankenhaus Buchholz, Onkologische Schwerpunktpraxis, Klinikum Chemnitz, Regiomed Kliniken GmbH, Carl‐Thiem‐Klinikum Cottbus, Klinikum Darmstadt, Onkologische Schwerpunktpraxis, Gemeinschaftspraxis für Hämatologie und Onkologie, Fachpraxis für Hämatologie und Onkologie, Universitätsklinikum Essen, Evangelisches Krankenhaus Essen‐Werden Zentrum für Innere Medizin, Universitätsklinikum Frankfurt, Agaplesion Medizinisches Versorgungszentrum, MVZ) Frankfurt, Krankenhaus Nordwest, Interdisziplinäres Facharztzentrum, IFS) Frankfurt, Vitanus GmbH, Frankfurter Rotkreuz‐Kliniken, PIOH‐Praxis für Internistische Onkologie und Hämatologie, Onkologische Facharztpraxis, Facharztpraxis für Hämatologie und Onkologie, Kath. Krankenhaus Hagen, Asklepios Klinik Altona, Asklepios Klinik St. Georg, Hämatologisch‐Onkologische Praxis Altona, Facharztpraxis für Hämatologie und Onkologie, OncoResearch Lerchenfeld UG, Evangelisches Krankenhaus Hamm gGmbH, Onkologische Schwerpunktpraxis, Klinikum Hanau GmbH, Klinikum Region Hannover, Onkologisches Ambulanzzentrum OAZ Hannover, Universitätsklinikum Heidelberg, Onkologische Schwerpunktpraxis, Onkologische Schwerpunktpraxis Heilbronn, SLK Kliniken Heilbronn GmbH, Facharztpraxis für Hämatologie und Tumorerkrankungen, Universitätsklinikum des Saarlandes, Klinikum Idar‐Oberstein, Schwerpunktpraxis für Hämatologie und Onkologie, Gemeinschaftspraxis für Hämatologie, Universitätsklinikum Köln, Onkologie Köln, Praxis Internistischer Onkologie und Hämatologie, Kliniken Köln, Facharztpraxis für Hämatologie, Onkologisches Zentrum Lebach, Klinikum der Stadt Ludwigshafen am Rhein, Onkologische Schwerpunktpraxis Lüneburg, Universitätsmedizin der Johannes Gutenberg‐Universität Mainz, MED Facharztzentrum, Universitätsmedizin Mannheim, Mannheimer Onkologie Praxis, Facharztpraxis für Innere Medizin, Praxis für Innere Medizin, AöR) Johannes Wesling Klinikum Minden, Kliniken Maria Hilf, Städtisches Klinikum München, Facharztpraxis für Innere Medizin, medius Kliniken, Onkologische Facharztpraxis, Paracelsus Kliniken, medius Kliniken, Medizinisches Versorgungszentrum am Siloah St. Trudbert‐Klinikum, Onkologische Praxis Pinneberg, Gemeinschaftspraxis Innere Medizin/Onkologie, Facharztpraxis für Onkologie, Diakonie‐Klinikum Schwäbisch Hall, Zaho‐Zentrum für ambulante Hämatologie und Onkologie, Diakonie Klinikum Jung‐Stilling, Gastroenterologie Onkologie Bodensee, Onkologische Schwerpunktpraxis Speyer, Marienhospital Stuttgart, Krankenhaus der Barmherzigen Brüder Trier, Klinikum Mutterhaus der Borromäerinnen Trier, Onkologische Schwerpunktpraxis am Brüderkrankenhaus Trier, Onkologie Rheinsieg, Universität Tübingen, OMM Optimed Mundial GmbH, Facharztpraxis für Onkologie, Ammerland Klinik, Facharztpraxis für Onkologie   +125 more
wiley   +1 more source

Prognostic factors in monoclonal gammopathy of undetermined significance

Haematologica, 2008
A retrospective evaluation of 285 patients with monoclonal gammopathy of undetermined significance was performed to identify variables associated with progression, actuarial progression free survival (PFS) and overall survival (OS).
Federico Sackmann, Miguel Arturo Pavlovsky, Claudia Corrado, Marco Pizzolato, Mariel Alejandre, Santiago Pavlovsky   +5 more
doaj   +1 more source

Clinicopathological characteristics of patients with paraproteinemia and renal damage

European Journal of Medical Research, 2021
Background This study aimed to analyze the clinicopathological characteristics of patients with paraproteinemia and renal damage. Methods Ninety-six patients from 2014 to 2018 with paraproteinemia and renal damage were enrolled and the clinical data ...
Xuanli Tang, Feng Wan, Jin Yu, Xiaohong Li, Ruchun Yang, Bin Zhu   +5 more
doaj   +1 more source

Trends in Smoldering Myeloma Incidence in the United States From Cancer Registries, 2012–2022

American Journal of Hematology, EarlyView.
Rong Wang, Amy J. Davidoff, Martin Schoen, John H. Huber, Eric J. Feuer, Jennifer Ruhl, Natalia Neparidze, Xiaomei Ma, Su‐Hsin Chang, Shi‐Yi Wang   +9 more
wiley   +1 more source

Cryoglobulinemia: An update on classification, pathophysiology, clinical presentation, and management

Journal of Internal Medicine, Volume 299, Issue 2, Page 196-215, February 2026.
Abstract Cryoglobulinemia (CG) is defined by the presence of serum immunoglobulins that precipitate below 37°C and redissolve upon rewarming. It is classified into three types based on immunoglobulin composition. Type I, a rare form, involves monoclonal IgM or IgG and is linked to lymphoproliferative disorders.
Anna Linda Zignego, Laura Gragnani, Marcella Visentini, Riccardo Bomben, Luca Arcaini, Clodoveo Ferri, Valter Gattei, Cesare Mazzaro   +7 more
wiley   +1 more source

Monoclonal Gammopathy of Undetermined Significance (MGUS)Monoclonal Gammopathy of Undetermined Significance (MGUS).

Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti, 2019
Monoclonal gammopathy of undetermined significance (MGUS) is one of the most prevalent premalignant conditions associated with a risk of malignant transformation to multiple myeloma (MM) or other forms of lymphoproliferative disorders with risk of progression of approximately 1% per year.
Sandecká, Viera, Pour, Ludek, Adam, Zdeněk, Krejčí, Marta, Štork, Martin, Ševčíková, Sabina, Král, Zdeněk   +6 more
openaire   +1 more source