Results 21 to 30 of about 363,626 (259)

The Time Course of Monocytes Infiltration After Acoustic Overstimulation

Frontiers in Cellular Neuroscience, 2022
Cochlea macrophages regulate cochlea inflammation and may harbors the potentials to protect hearing function from injury, including acoustic overstimulation. Cochlea macrophage numbers increase at 3–7 days after acoustic stimulation.
Seung Ho Shin, Jinsei Jung, Jinsei Jung, Haeng Ran Park, Nam Suk Sim, Jae Young Choi, Jae Young Choi, Seong Hoon Bae   +7 more
doaj   +1 more source

Monocyte Heterogeneity: Consequences for Monocyte-Derived Immune Cells [PDF]

Journal of Immunology Research, 2016
Blood monocytes are precursors of dendritic cells, macrophages, and osteoclasts. They are a heterogeneous cell population with differences in size, phenotype, and function. Although monocytes maintain several tissue-specific populations of immune cells in homeostasis, their contribution to populations of dendritic cells, macrophages, and osteoclasts is
Sara Sprangers, Teun J. de Vries, Vincent Everts   +2 more
openaire   +6 more sources

Assessing the Functional Heterogeneity of Monocytes in Human Septic Shock: a Proof-of-Concept Microfluidic Assay of TNFα Secretion

Frontiers in Immunology, 2021
ObjectiveThe development of advanced single-cell technologies to decipher inter-cellular heterogeneity has enabled the dynamic assessment of individual cells behavior over time, overcoming the limitation of traditional assays.
Jean-François Llitjos, Jean-François Llitjos, Jean-François Llitjos, Yacine Bounab, Christophe Rousseau, Christophe Rousseau, Sophie Dixneuf, Blandine Rimbault, Jean-Daniel Chiche, Jean-Daniel Chiche, Jean-Daniel Chiche, Julien Textoris, Julien Textoris, Julien Textoris, Frédéric Pène, Frédéric Pène, Frédéric Pène, Christophe Védrine   +17 more
doaj   +1 more source

Effects of different obesogenic diets on joint integrity, inflammation and intermediate monocyte levels in a rat groove model of osteoarthritis

Frontiers in Physiology, 2023
Introduction: Obesogenic diets aggravate osteoarthritis (OA) by inducing low-grade systemic inflammation, and diet composition may affect OA severity. Here, we investigated the effect of diet on joint damage and inflammation in an OA rat model.Methods ...
K. Warmink, J. L. Rios, D. R. van Valkengoed, P. Vinod, N. M. Korthagen, N. M. Korthagen, H. Weinans, H. Weinans   +7 more
doaj   +1 more source

Targeting Histone Deacetylases in Myeloid Cells Inhibits Their Maturation and Inflammatory Function With Limited Effects on Atherosclerosis

Frontiers in Pharmacology, 2019
Monocytes and macrophages are key drivers in the pathogenesis of inflammatory diseases. Epigenetic targets have been shown to control the transcriptional profile and phenotype of these cells.
Rosario Luque-Martin, Jan Van den Bossche, Rebecca C. Furze, Annette E. Neele, Saskia van der Velden, Marion J.J. Gijbels, Marion J.J. Gijbels, Cindy P.P.A. van Roomen, Sharon G. Bernard, Wouter J. de Jonge, Inmaculada Rioja, Rab K. Prinjha, Huw D. Lewis, Palwinder K. Mander, Menno P.J. de Winther, Menno P.J. de Winther   +15 more
doaj   +1 more source

Causes and Consequences of Innate Immune Dysfunction in Cirrhosis

Frontiers in Immunology, 2019
Liver cirrhosis is an increasing health burden and public health concern. Regardless of etiology, patients with cirrhosis are at risk of a range of life-threatening complications, including the development of infections, which are associated with high ...
Katharine Margaret Irvine, Isanka Ratnasekera, Elizabeth E. Powell, Elizabeth E. Powell, David Arthur Hume   +4 more
doaj   +1 more source

The Leukocyte Subtype Counts and Ratios Can Effectively Predict the Risk of Arterial Stiffness Assessed by Cardio-Ankle Vascular Index: A Retrospective Study

Frontiers in Cardiovascular Medicine, 2021
Background: Arterial stiffness was the pathological basis and risk factor of cardiovascular diseases, with chronic inflammation as the core characteristic.
Yaoling Wang, Ruiyun Wang, Lijuan Bai, Yun Liu, Lihua Liu, Linfeng He, Benling Qi   +6 more
doaj   +1 more source

Single Cell RNA-Seq and Machine Learning Reveal Novel Subpopulations in Low-Grade Inflammatory Monocytes With Unique Regulatory Circuits

Frontiers in Immunology, 2021
Subclinical doses of LPS (SD-LPS) are known to cause low-grade inflammatory activation of monocytes, which could lead to inflammatory diseases including atherosclerosis and metabolic syndrome.
Jiyoung Lee, Jiyoung Lee, Shuo Geng, Song Li, Song Li, Liwu Li   +5 more
doaj   +1 more source

Tauroursodeoxycholic acid regulates macrophage/monocyte distribution and improves spinal microenvironment to promote nerve regeneration through inhibiting NF-κB signaling pathway in spinal cord injury

Frontiers in Pharmacology
IntroductionFollowing spinal cord injury (SCI), blood-borne monocytes infiltrate the spinal cord, differentiate into macrophages, and dominate the lesion site.
Yonghui Hou, Yonghui Hou, Yage Zhang, Yage Zhang, Lin Ma, Lin Ma, Dan Luo, Dan Luo, Wanshun Wang, Wanshun Wang, Shunmei E., Chengxi Huang, Yu Hou, Yu Hou, Shudong Chen, Shudong Chen, Jiheng Zhan, Jiheng Zhan, Liangliang Xu, Liangliang Xu, Dingkun Lin, Dingkun Lin   +21 more
doaj   +1 more source

Comparative Proteomic Analysis Reveals Varying Impact on Immune Responses in Phorbol 12-Myristate-13-Acetate-Mediated THP-1 Monocyte-to-Macrophage Differentiation

Frontiers in Immunology, 2021
Macrophages are sentinels of the innate immune system, and the human monocytic cell line THP-1 is one of the widely used in vitro models to study inflammatory processes and immune responses. Several monocyte-to-macrophage differentiation protocols exist,
Sneha M. Pinto, Sneha M. Pinto, Hera Kim, Yashwanth Subbannayya, Miriam S. Giambelluca, Korbinian Bösl, Korbinian Bösl, Liv Ryan, Animesh Sharma, Richard K. Kandasamy   +9 more
doaj   +1 more source