Results 111 to 120 of about 613,326 (371)

Monocytes and Macrophages as Viral Targets and Reservoirs

International Journal of Molecular Sciences, 2018
Viruses manipulate cell biology to utilize monocytes/macrophages as vessels for dissemination, long-term persistence within tissues and virus replication. Viruses enter cells through endocytosis, phagocytosis, macropinocytosis or membrane fusion.
E. Nikitina, I. Larionova, E. Choinzonov, J. Kzhyshkowska   +3 more
semanticscholar   +1 more source

Tryptophan‐sensing receptor GPR142 expression levels are directly regulated by proinflammatory cytokines in ghrelin‐producing cells

FEBS Open Bio, EarlyView.
GPR142, a tryptophan‐sensing receptor, stimulates gastrointestinal hormones like ghrelin and is linked to inflammation regulation. Proinflammatory cytokines suppress ghrelin production, while tryptophan levels decrease via IDO1 activation. Our findings reveal that proinflammatory cytokines directly regulate GPR142 expression in ghrelin‐producing cells,
Yoko Ueda, Hiroshi Iwakura, Takuya Ensho, Mika Bando‐Shimizu, Asako Doi, Norihiko Matsutani, Shuhei Morita, Hidefumi Inaba, Hiroyuki Ariyasu, Naoki Fukuda, Keiji Hayata, Toshiyasu Ojima, Masahiro Nishi, Taka‐aki Matsuoka, Hiroki Yamaue, Takashi Akamizu   +15 more
wiley   +1 more source

Senescence in Monocytes Facilitates Dengue Virus Infection by Increasing Infectivity

Frontiers in Cellular and Infection Microbiology, 2020
Aging and chronic condition increase the incidence of dengue virus (DENV) infection, generally through a mechanism involving immunosenescence; however, the alternative effects of cellular senescence, which alters cell susceptibility to viral infection ...
Tzu-Han Hsieh, Tsung-Ting Tsai, Chia-Ling Chen, Ting-Jing Shen, Ting-Jing Shen, Ming-Kai Jhan, Ming-Kai Jhan, Po-Chun Tseng, Po-Chun Tseng, Chiou-Feng Lin, Chiou-Feng Lin, Chiou-Feng Lin, Chiou-Feng Lin   +12 more
doaj   +1 more source

Convolutional Neural Network and decision support in medical imaging: case study of the recognition of blood cell subtypes [PDF]

CEUR-WS.org/Vol-2647 (2019), pp. 128-140, 2019
Identifying and characterizing the patient's blood samples is indispensable in diagnostics of malignance suspicious. A painstaking and sometimes subjective task is used in laboratories to manually classify white blood cells. Neural mathematical methods as deep learnings can be very useful in the automated recognition of blood cells.
arxiv  

Oxysterols in Vascular Cells and Role in Atherosclerosis [PDF]

Implication of Oxysterols and Phytosterols in Aging and Human Diseases, 1440, Springer International Publishing, pp.213-229, 2024, Advances in Experimental Medicine and Biology
Atherosclerosis is a major cardiovascular complication of diseases associated with elevated oxidative stress such as type 2 diabetes and metabolic syndrome. In these situations, low density lipoproteins (LDL) undergo oxidation. Oxidized LDL display proatherogenic activities through multiple and complex mechanisms which lead to dysfunctions of vascular ...
arxiv   +1 more source

Microglial recruitment of IL-1β producing monocytes to brain endothelium causes stress-induced anxiety

Molecular Psychiatry, 2017
Psychosocial stress contributes to the development of anxiety and depression. Recent clinical studies have reported increased inflammatory leukocytes in circulation of individuals with stress-related psychiatric disorders.
D. Mckim, Michael D. Weber, A. Niraula, C. Sawicki, Xiaoyu Liu, B. Jarrett, Karol Ramirez-Chan, Yufen Wang, Rachel Roeth, Ana D. Sucaldito, Carly G. Sobol, N. Quan, J. Sheridan, J. Godbout   +13 more
semanticscholar   +1 more source

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

Shuyi, A Name After Dendritic Cell-mediated Immunological Memory [PDF]

arXiv, 2019
Immunological memory is a fundamental theory of modern immunology, which is traditionally believed to be mediated only by B and T lymphocytes that recognize antigen epitopes in a receptor-restricted manner. During the last decade data accumulated to show that monocytes and macrophages, the two main initiators of innate immune response, also built up a "
arxiv  

FcγR-mediated SARS-CoV-2 infection of monocytes activates inflammation

Nature, 2022
Caroline Junqueira, Â. Crespo, S. Ranjbar, Luna B. de Lacerda, Mercedes Lewandrowski, Jacob Ingber, B. Parry, Sagi Ravid, S. Clark, Marie Rose Schrimpf, Felicia Ho, Caroline Beakes, J. Margolin, Nicole Russell, Kyle R. Kays, J. Boucau, Upasana Das Adhikari, Setu M. Vora, Valerie Leger, L. Gehrke, L. Henderson, E. Janssen, D. Kwon, C. Sander, J. Abraham, M. Goldberg, Haoying Wu, Gautam Mehta, S. Bell, A. Goldfeld, M. Filbin, J. Lieberman   +31 more
semanticscholar   +1 more source

Inflammatory Ly6Chi monocytes and their conversion to M2 macrophages drive atherosclerosis regression

Journal of Clinical Investigation, 2017
Atherosclerosis is a chronic inflammatory disease, and developing therapies to promote its regression is an important clinical goal. We previously established that atherosclerosis regression is characterized by an overall decrease in plaque macrophages ...
Karishma Rahman, Y. Vengrenyuk, S. Ramsey, Noemi Rotllan Vila, N. Girgis, Jianhua Liu, V. Gusarova, J. Gromada, Ada Weinstock, K. Moore, P. Loke, E. Fisher   +11 more
semanticscholar   +1 more source